Abstract: The present invention involves the use of 2,4-disulfonyl phenyl tert-butyl nitrone (2,4-ds-PBN) in the treatment and prevention of gliomas. The 2,4-ds-PBN may be used alone or combined with other traditional chemo- and radiotherapies and surgery, to treat or prevent glioma occurrence, recurrence, spread, growth, metastasis, or vascularization.
Abstract: Quantitative datasets are created and used in the identification, monitoring and treatment of disease states and characterization of biological conditions.
Type:
Application
Filed:
March 27, 2014
Publication date:
July 17, 2014
Applicant:
Oklahoma Medical Research Foundation
Inventors:
Michael Centola, Philip J. Alex, Nicholas Knowlton, Mark Barton Frank
Abstract: A method scores a sample, by receiving a first dataset associated with a first sample obtained from a first subject, wherein said first dataset comprises quantitative data for at least two markers selected from the group consisting of: CCL22; CHI3L1; COMP; CRP; CSF1; CXCL10; EGF; ICAM1; ICAM3; ICTP; IL1B; IL2RA; IL6; IL6R; IL8; LEP; MMP1; MMP3; PYD; RETN; SAA1; THBD; TIMP1; TNFRSF11B; TNFRSF1A; TNFSF11; VCAM1; and VEGFA; and determining a first SDI score from said first dataset using an interpretation function, wherein the first SDI score provides a quantitative measure of the rate of change in joint structural damage in said first subject.
Type:
Application
Filed:
November 7, 2011
Publication date:
May 22, 2014
Applicants:
OKLAHOMA MEDICAL RESEARCH FOUNDATION, CRESCENDO BIOSCIENCE
Inventors:
William A. Hagstrom, David N. Chernoff, Yijing Shen, Guy L. Cavet, Michael Centola
Abstract: Methods, devices, and kits for diagnosing or evaluating irritable bowel syndrome employ an analysis for the presence and amount of specific cytokines. The levels of such cytokines provide an index for diagnosis and/or evaluation of therapeutic response. Samples to be tested include peripheral blood, serum, plasma, or tissue from a human subject having or suspected of having Irritable Bowel Syndrome.
Type:
Application
Filed:
January 13, 2012
Publication date:
May 8, 2014
Applicants:
OKLAHOMA MEDICAL RESEARCH FOUNDATION, THE JOHNS HOPKINS UNIVERSITY
Inventors:
Xuhang Li, Philip Alex, Michael Centola, Nicholas Knowlton
Abstract: Hyper-inflammatory responses can lead to a variety of diseases including sepsis. It is now shown that extracellular histones released in response to inflammatory challenge are mediators contributing to endothelial dysfunction, organ failure and death during sepsis. As such, they can be targeted pharmacologically by inhibitors, as well as used as biomarkers for prognosis of sepsis and other diseases.
Type:
Grant
Filed:
November 6, 2008
Date of Patent:
May 6, 2014
Assignee:
Oklahoma Medical Research Foundation
Inventors:
Charles T. Esmon, Jun Xu, Xiaomei Zhang
Abstract: Proteases such as memapsin 2 are important enzymes, playing roles in a variety of diseases including Alzheimer's Disease. The inventors have developed inhibitors of memapsin 2 and methods of use therefore in the treatment of disease.
Type:
Application
Filed:
August 28, 2013
Publication date:
March 6, 2014
Applicants:
Purdue Research Foundation, Oklahoma Medical Research Foundation
Inventors:
Jordan Tang, Venkateswararao Kalapala, Arun K. Ghosh
Abstract: A method of in vitro fucosylation of selectin ligands on cord blood-derived hematopoietic stem cells for bone marrow transplantation is disclosed. In this method, an effective amount of an ?1,3-fucosyltransferase, e.g., ?1,3-fucosyltransferase VI, is used in vitro to treat cord blood-derived hematopoietic stem cells to convert non-functional PSGL-1 or other ligands on the cell surface into functional forms that bind selectins, especially P-selectin or E-selectin. The treated cells have enhanced effectiveness in reconstituting bone marrow in patients in need of such therapy.
Abstract: The present invention involves the use of 2,4-disulfonyl phenyl tert-butyl nitrone (2,4-ds-PBN) in the treatment and prevention of gliomas. The 2,4-ds-PBN may be used alone or combined with other traditional chemo- and radiotherapies and surgery, to treat or prevent glioma occurrence, recurrence, spread, growth, metastasis, or vascularization.
Abstract: The invention provides methods for diagnosing, treating, or evaluating inflammatory and autoimmune diseases by sampling peripheral blood, serum, plasma, tissue, cerebrospinal fluid, or other bodily fluids from a human subject having a suspected diagnosis. The sample is analyzed for the presence and amount of certain cytokines, which provides the diagnosis, prognosis or evaluation of therapeutic response.
Type:
Application
Filed:
September 3, 2013
Publication date:
January 2, 2014
Applicants:
Oklahoma Medical Research Foundation, The Board of Regents of the University of Oklahoma
Inventors:
Cherie M. Chappell, Michael B. Centola, Philip J. Alex, Kenneth Hensley
Abstract: The present invention relates to the field of inflammatory bowel disease. More specifically, the present invention relates to the use of cytokines to detect, diagnose, and assess inflammatory bowel disease. In one embodiment, a method for diagnosing Crohn's Disease (CD) in a patient comprises the steps of (a) collecting a sample from the patient; (b) measuring the levels of at least one cytokine in the sample collected from the patient; and (c) comparing the levels of the at least one cytokine with predefined cytokine levels, wherein a correlation between the cytokine levels in the patient sample and predefined cytokine levels indicates that the patient has CD. In a specific embodiment, the at least one cytokine comprises Interferon (IFN)-gamma, Interleukin (IL)-1beta, IL-6, IL-8, IL-12, IL-17 and CXCL10.
Type:
Application
Filed:
September 14, 2011
Publication date:
November 14, 2013
Applicants:
OKLAHOMA MEDICAL RESEARCH FOUNDATION, The Johns Hopkins University
Inventors:
Xuhang Li, Philip J. Alex, Michael B. Centola, Nicholas Knowlton
Abstract: High efficient methods for producing an antibody molecule that binds an antigen are described. The methods include obtaining a population of PBMC enriched for CD19highCD3negCD20low to negCD38highCD27high cells from a mammal exposed to an antigen from sample of cells enriched for PBMC. The cells are isolated from a sample obtained at a time that the fraction of PBMC expressing antibody reactive to the antigen is at a high level. Sequences encoding heavy and light chain variable domains are prepared in a manner that allow production of molecules with natural heavy and light chain pairing.
Type:
Grant
Filed:
April 30, 2009
Date of Patent:
October 22, 2013
Assignees:
Oklahoma Medical Research Foundation, Emory University
Inventors:
Rafi Ahmed, Joseph Miller, Patrick C. Wilson, J. Donald Capra, Jens Wrammert
Abstract: Proteases such as memapsin-1 are import enzymes, playing roles in a variety of diseases including diabetes. The inventors have developed inhibitors of memapsin 1 and methods of use therefore in the treatment of disease.
Type:
Application
Filed:
March 11, 2013
Publication date:
October 3, 2013
Applicant:
Oklahoma Medical Research Foundation
Inventors:
Jordan Tang, Xiangping Huang, Deborah Downs
Abstract: A population of cells possesses enhanced selectin binding based upon a fucosylated selectin ligand present on a surface thereof. Methods of producing the population of cells, along with therapeutic methods of using the cells, are also disclosed.
Abstract: Nitrone-based compositions are disclosed that may be utilized for the prevention and treatment of a variety of ophthalmic diseases or conditions where RPE65 protein isomerohydrolase is implicated. Methods of production and use of said nitrone-based compositions, as well as pharmaceutical and ophthalmic compositions containing same, are disclosed.
Type:
Application
Filed:
February 25, 2013
Publication date:
August 29, 2013
Applicants:
Oklahoma Medical Research Foundation, The Board of Regents of the University of Oklahoma
Inventors:
Robert E. Anderson, Nawajes A. Mandal, Jian-Xing Ma, Gennadiy Moiseyev, Robert A. Floyd
Abstract: The present invention concerns glutathione-lanthionine compounds, the process of preparing such compounds, and their use. The invention also concerns methods of using the compounds and derivatives and combinations of these compounds in the treatment and/or prevention diseases, including diseases affecting the central nervous system.
Type:
Application
Filed:
August 24, 2011
Publication date:
August 15, 2013
Applicants:
OKLAHOMA MEDICAL RESEARCH FOUNDATION, UNIVERSITY OF TOLEDO
Abstract: The present invention is directed to particular monoclonal antibodies and fragments thereof that find use in the detection, prevention and treatment of Streptococcus pneumoniae infections. In particular, these antibodies may kill Streptococcus pneumoniae or limit the replication of Streptococcus pneumoniae. Also disclosed are improved methods for producing such monoclonal antibodies.
Abstract: Agonists and antagonists of nAChR?7 and their use as therapeutic agents for treating and managing inflammatory bowel diseases (IBD), such as Crohn's disease (CD) and ulcerative colitis (UC), are disclosed. Agonists and antagonists of nAChR?7 and their use as therapeutic agents for treating and managing inflammatory bowel diseases (IBD), such as Crohn's disease (CD) and ulcerative colitis (UC), are disclosed.
Type:
Application
Filed:
June 24, 2011
Publication date:
August 1, 2013
Applicants:
OKLAHOMA MEDICAL RESEARCH FOUNDATION, THE JOHNS HOPKINS UNIVERSITY
Inventors:
Xuhang Li, Philip Alex, Michael B. Centola
Abstract: The current invention provides methods and compositions for treating sensorineural hearing loss including but not limited to acute acoustic trauma (AAT). The composition includes compounds which function as free radical traps such as phenyl butyl nitrone (PBN), free radical scavengers, such as edaravone, resveratrol, ebselen and iron chelator and compounds from the family of antioxidant compounds including, but not limited to, N-acetylcysteine (NAC), Acetyl-L-Carnitine (ALCAR), glutathione monoethylester, ebselen, D-methionine and carbamathione. The compositions of the current invention may be delivered by injections or orally.
Abstract: The invention features antibodies, e.g., chimeric and humanized antibodies, that recognize (i.e., bind) P-selectin. The P-selectin antibodies prevent P-selectin from binding to its cognate receptor. The P-selectin antibodies can be used to treat inflammatory and thrombotic conditions, e.g., sickle cell disease, pain crisis associated with sickle cell disease, deep vein thrombosis, asthma, rheumatoid arthritis, psoriasis, and ischemia reperfusion injury in a patient in need thereof.
Type:
Grant
Filed:
November 30, 2007
Date of Patent:
February 19, 2013
Assignees:
Selexys Pharmaceuticals Corporation, Oklahoma Medical Research Foundation
Inventors:
Rodger P. McEver, Richard Alvarez, Ziad Kawar
Abstract: The present invention relates to a system and a medium for analyzing one or more analytes in rheumatoid arthritis subjects to determine whether the subject is at increased risk of diseases such as a cardiovascular disease, the subject's current cardiovascular disease burden, and the likelihood of cardiovascular disease progression in the subject. In addition, the present invention further provides methods for analyzing data to determine risk of cardiovascular disease, current cardiovascular disease burden, and the likelihood of cardiovascular disease progression in a rheumatoid arthritis subject.
Type:
Application
Filed:
April 5, 2010
Publication date:
May 10, 2012
Applicants:
THE JOHNS HOPKINS UNIVERSITY, OKLAHOMA MEDICAL RESEARCH FOUNDATION
Inventors:
Petar Alaupovic, Michael Centola, Joan Bathon, Jon Giles, Nicholas Knowlton, Adam Joshua Payne