Patents Assigned to Oligasis, LLC
  • DUAL PDGF/VEGF ANTAGONISTS
    Publication number: 20150376271
    Abstract: The invention provides a dual VEGF/PDGF antagonist comprising a VEGF antagonist linked to a PDGF antagonist. The VEGF antagonist is an antibody to a VEGF or VEGFR or is a VEGFR extracellular trap segment (i.e., a segment from the extracellular region of one or more VEGFR receptors that inhibits binding of at least one VEGFR to at least one VEGF). The PDGF antagonist is an antibody to a PDGF or PDGFR or is a PDGFR extracellular trap segment (i.e., segment from the extracellular region of one or more PDGFRs, which inhibits binding of at least one PDGFR and at least one PDGF). The dual antagonist is preferably conjugated to a half-life extending moiety, such as a HEMA-PC polymer. The dual antagonist is particularly useful for treating wet aged related macular degeneration.
    Type: Application
    Filed: June 29, 2015
    Publication date: December 31, 2015
    Applicant: OLIGASIS, LLC
    Inventors: D. Victor Perlroth, Stephen A. Charles, James Aggen, Didier Benoit, Wayne To, Lidia Mosyak, Laura Lin, Justin Cohen, Tetsuya Ishino, William Somers
  • Acryloyloxyethylphosphorylcholine Containing Polymer Conjugates And Their Preparation
    Publication number: 20150050714
    Abstract: The present invention relates to polymeric reagents and conjugates thereof, methods for synthesizing the polymeric reagents and conjugates, pharmaceutical compositions comprising the conjugates and methods of using the polymer conjugates including therapeutic methods where conjugates are administered to patients.
    Type: Application
    Filed: August 11, 2014
    Publication date: February 19, 2015
    Applicant: OLIGASIS, LLC
    Inventor: Stephen A. Charles
  • TARGETED DRUG PHOSPHORYLCHOLINE POLYMER CONJUGATES
    Publication number: 20150004128
    Abstract: The present invention provides random copolymers containing phosphorylcholine and one or more functional agents, and methods of preparing such random copolymers.
    Type: Application
    Filed: April 29, 2014
    Publication date: January 1, 2015
    Applicant: Oligasis, LLC
    Inventors: Stephen A. Charles, D. Victor Perlroth
  • Acryloyloxyethylphosphorylcholine containing polymer conjugates and their preparation
    Patent number: 8846021
    Abstract: The present invention relates to polymeric reagents and conjugates thereof, methods for synthesizing the polymeric reagents and conjugates, pharmaceutical compositions comprising the conjugates and methods of using the polymer conjugates including therapeutic methods where conjugates are administered to patients.
    Type: Grant
    Filed: August 5, 2013
    Date of Patent: September 30, 2014
    Assignee: Oligasis, LLC
    Inventor: Stephen A. Charles
  • Targeted drug phosphorylcholine polymer conjugates
    Patent number: 8765432
    Abstract: The present invention provides random copolymers containing phosphorylcholine and one or more functional agents, and methods of preparing such random copolymers.
    Type: Grant
    Filed: May 10, 2010
    Date of Patent: July 1, 2014
    Assignee: Oligasis, LLC
    Inventors: Stephen A. Charles, D. Victor Perlroth
  • Acryloyloxyethylphosphorylcholine Containing Polymer Conjugates And Their Preparation
    Publication number: 20130337534
    Abstract: The present invention relates to polymeric reagents and conjugates thereof, methods for synthesizing the polymeric reagents and conjugates, pharmaceutical compositions comprising the conjugates and methods of using the polymer conjugates including therapeutic methods where conjugates are administered to patients.
    Type: Application
    Filed: August 5, 2013
    Publication date: December 19, 2013
    Applicant: Oligasis, LLC
    Inventor: Stephen A. Charles