Abstract: The disclosure describes a method of inhibiting TNF in subjects comprising administering a TNF inhibiting amount of an extract of Eleutherococcus senticosus maxim to a subject. In addition, the present disclosure provides a method of inhibiting TNF in a cell line comprising administering to the cell line a TNF inhibiting amount of an extract from Eleutherococcus senticosus maxim. Finally, the disclosure provides a method of treating a TNF mediated disorder in a subject, comprising administering an effective amount of an extract of Eleutherococcus senticosus maxim to the subject.

Abstract: The invention provides a method of modulating the immune system. Also provided is a method of treating a pathology associated with increased levels of a tumor necrosis factor. The invention further provides a method of treating a pathology resulting from infection by human immunodeficiency virus. Also provided is a method of treating chronic graft vs. host disease. Finally, the invention provides a method of promoting wound healing in a subject.