Abstract: A method and solution for perioperatively inhibiting a variety of pain and inflammation processes at wounds from general surgical procedures including oral/dental procedures. The solution preferably includes multiple pain and inflammation inhibitory at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for preemptive inhibition of pain and while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents.

Abstract: A method and solution for perioperatively inhibiting a variety of pain, inflammation, spasm and restenosis processes resulting from cardiovascular or general surgical, therapeutic and diagnostic procedures. The solution preferably includes multiple pain and inflammation inhibitory agents, including at least one local anesthetic agent, and spasm inhibitory agents at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. Specific preferred embodiments of the solution of the present invention for use in cardiovascular and general vascular procedures also include anti-restenosis agents.

Abstract: A medical fastener (18), preferably bioabsorbable, is used for repairing torn soft tissue, particularly meniscal tissue (16). The fastener (18) can have an enlarged head (22) at the proximate end to engage meniscal tissue (16) adjacent to a tear (14), and a pointed distal tip (21) at the other end to ease insertion of the fastener (18) into the meniscus (16). The shank (20) of the fastener (18) bridges across the tear (14). Opposite ends of the shank (20) are secured in the meniscal tissue (16) by a medical adhesive, preferably bioabsorbable, and preferably at locations remote from the tear (14) so as not to interfere with healing of the tear (14). The fastener (18) can have a blind bore (24) opening through the head (22) of the fastener (18) and extending through the shank (20) to a location close to the tip (21) and generally radial holes (26) communicating between the bore (24) and the exterior of the shank (20).

Abstract: A method and solution for perioperatively inhibiting a variety of pain, inflammation, spasm and restenosis processes resulting from cardiovascular or general surgical, therapeutic and diagnostic procedures. The solution preferably includes multiple pain and inflammation inhibitory agents, including at least one local anesthetic agent, and spasm inhibitory agents at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. Specific preferred embodiments of the solution of the present invention for use in cardiovascular and general vascular procedures also include anti-restenosis agents.

Abstract: A method and solution for perioperatively inhibiting a variety of pain and inflammation processes at wounds from general surgical procedures including oral/dental procedures. The solution preferably includes multiple pain and inflammation inhibitory at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for preemptive inhibition of pain and while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents.

Abstract: A method and solution for perioperatively inhibiting a variety of pain and inflammation processes at wounds from general surgical procedures including oral/dental procedures. The solution preferably includes multiple pain and inflammation inhibitory at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for preemptive inhibition of pain and while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents.

Abstract: A method and solution for perioperatively inhibiting a variety of pain and inflammation processes at wounds from general surgical procedures including oral/dental procedures. The solution preferably includes multiple pain and inflammation inhibitory at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for preemptive inhibition of pain and while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents.

Abstract: A method and solution for perioperatively inhibiting a variety of pain and inflammation processes at wounds from general surgical procedures including oral/dental procedures. The solution preferably includes multiple pain and inflammation inhibitory at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for preemptive inhibition of pain and while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents.

Abstract: A method and solution for perioperatively inhibiting a variety of pain and inflammation processes at wounds from general surgical procedures including oral/dental procedures. The solution preferably includes multiple pain and inflammation inhibitory at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for preemptive inhibition of pain and while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents.

Abstract: A rigid or semi-rigid reinforcement member is inserted into or over the damaged portion of an injured tendon or ligament. The tendon or ligament is connected to the reinforcement member such that the cord-member combination can immediately withstand normal tensile forces. The interconnection can be mechanical, such as by pins extending through the sleeve reinforcement member and cord. The sleeve can be bioabsorbable over a sufficiently long period of time that the cord is healed by the time the sleeve is absorbed.

Abstract: The damaged portion of an injured tendon or ligament (C) ("connective cord") is inserted into a thin, hollow sleeve (100, 110, 120, 130, 140, 160, 180, 200, 240, 260, 270, 300, 390, generically designated "S") and is connected to the sleeve (S) such that the cord-sleeve combination can immediately withstand normal tensile forces. The interconnection can be mechanical, such as by pins (22, 22',148, 150, 164, 188, 190, 206, 206', 210, 226, 230, 238, 239, 266, 286, 308) extending through the sleeve (S) and cord (C). The sleeve (S) can be bioabsorbable over a sufficiently long period of time that the cord (C) is healed by the time the sleeve (S) is absorbed.

Abstract: A method and solution for perioperatively inhibiting a variety of pain and inflammation processes at wounds from general surgical procedures including oral/dental procedures. The solution preferably includes multiple pain and inflammation inhibitory at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for preemptive inhibition of pain and while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents. One preferred solution to inhibit pain and inflammation includes a serotonin.sub.2 antagonist, a serotonin.sub.3 antagonist, a histamine antagonist, a serotonin agonist, a cyclooxygenase inhibitor, a neurokinin.sub.1 antagonist, a neurokinin.sub.2 antagonist, a purinoceptor antagonist, an ATP-sensitive potassium channel opener, a calcium channel antagonist, a bradykinin.sub.1 antagonist, a bradykinin.

Abstract: A method and solution for perioperatively inhibiting a variety of pain and inflammation processes resulting from arthroscopic surgery at a joint. The solution preferably includes multiple pain and inflammation inhibitory agents in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is introduced luminally to continuously irrigate an operative site during an arthroscopic procedure for preemptive inhibition of pain and inflammation while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents. One preferred solution to inhibit pain and inflammation includes a serotonin.sub.2 antagonist, a serotonin.sub.3 antagonist, a histamine antagonist, a serotonin agonist, a cyclooxygenase inhibitor, a neurokinin.sub.1 antagonist, a neurokinin.sub.2 antagonist, a purinoceptor antagonist, an ATP-sensitive potassium channel opener, a calcium channel antagonist, a bradykinin.sub.1 antagonist, a bradykinin.sub.

Abstract: A method and solution for perioperatively inhibiting a variety of pain, inflammation and smooth muscle spasm processes resulting from urologic procedures. The solution preferably includes multiple pain and inflammation inhibitory agents and spasm inhibitory agents at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is introduced luminally to continuously irrigate a urologic structure during a urologic procedure for preemptive inhibition of pain and inflammation and smooth muscle spasm while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents. One preferred solution to inhibit pain, inflammation, and spasm includes a serotonin.sub.2 antagonist, a histamine.sub.1 antagonist, a cyclooxygenase inhibitor, a neurokinin.sub.2 antagonist, a purine.sub.2X antagonist, an ATP-sensitive K.sup.+ channel antagonist, a Ca.sup.

Abstract: A method and solution for perioperatively inhibiting a variety of pain and inflammation processes at wounds from general surgical procedures including oral/dental procedures. The solution preferably includes multiple pain and inflammation inhibitory at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for preemptive inhibition of pain and while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents. One preferred solution to inhibit pain and inflammation includes a serotonin.sub.2 antagonist, a serotonin.sub.3 antagonist, a histamine antagonist, a serotonin agonist, a cyclooxygenase inhibitor, a neurokinin.sub.1 antagonist, a neurokinin.sub.2 antagonist, a purinoceptor antagonist, an ATP-sensitive potassium channel opener, a calcium channel antagonist, a bradykinin.sub.1 antagonist, a bradykinin.

Abstract: The damaged portion of an injured tendon or ligament (C) ("connective cord") is inserted into a thin, hollow sleeve (100, 110, 120, 130, 140, 160, 180, 200, 240, 260, 270, 300, 390, generically designated "S") and is connected to the sleeve (S) such that the cord-sleeve combination can immediately withstand normal tensile forces. the interconnection can be mechanical, such as by pins (22, 22', 148, 150, 164, 188, 190, 206, 206', 210, 226, 230, 238, 239, 266, 286, 308) extending through the sleeve (S) and cord (C). The sleeve (S) can be bioabsorbable over a sufficiently long period of time that the cord (C) is healed by the time the sleeve (S) is absorbed.

Abstract: A method and solution for perioperatively inhibiting a variety of pain, inflammation, spasm and restenosis processes resulting from cardiovascular or general vascular therapeutic and diagnostic procedures. The solution preferably includes multiple pain and inflammation inhibitory agents and spasm inhibitory agents at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. Specific preferred embodiments of the solution of the present invention for use in cardiovascular and general vascular procedures also include anti-restenosis agents. The solution is introduced luminally to continuously irrigate an arterial site during an operative/interventional or diagnostic procedure for preemptive inhibition of pain and inflammation, vascular and non-vascular smooth muscle spasm, and restenosis while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents.