Abstract: A description is given of conjugates of vinca alkaloid of the indole-dihydroindole type with a protein or a protein fragment, corresponding to the general formula ##STR1## in which R.sub.1 denotes a protein or a protein fragment;R.sub.2 is COO(C.sub.1-3 alkyl) or CO-R.sub.7 where R.sub.7 isNH.sub.2 or an amino acid ester or peptide ester;R.sub.3 is H, CH.sub.3 or CHO;when R.sub.5 and R.sub.6 are taken separately, R.sub.6 is H and one of R.sub.4 and R.sub.5 is ethyl and the other is H or OH;when R.sub.5 and R.sub.6 are taken together with the carbon atoms to which they are attached, they form an oxirane ring and R.sub.4 is ethyl, andA is a residue of a bifunctional organic derivative of the maleoylamino acid or maleoyl peptide or maleoylphenoxy type.

Abstract: The invention relates to new conjugates of vinblastine and some of its known derivatives with proteins, fragments thereof, aminoacids or amines, which are useful as anti-tumor agents. The invention also relates to some intermediates which are active in chemotherapy, and amino derivatives thereof.These compounds correspond to the following general formula ##STR1## in which A represents an acetylamino-, trifluoroacetylamino- or carbobenzyloxyamino- substituted --CO(CH.sub.2).sub.n CO-- or ##STR2## in which n is 1 to 5, R.sub.1 represents an optionally modified protein radical,R.sub.2 represents a methoxy group, an amino group or an alpha-aminoacid ester radical which is bonded via a bond of the amide type and in which the ester group contains 1 to 6 carbon atoms, and R.sub.3 represents hydrogen or hydroxyl.

Abstract: A description is given of conjugates of vinca alkaloid of the indole-dihydroindole type with a protein or a protein fragment, corresponding to the general formula ##STR1## in which R.sub.1 denotes a protein or a protein fragment;R.sub.2 is COO(C.sub.1-3 alkyl) or CO--R.sub.7 where R.sub.7 is NH.sub.2 or an amino acid ester or peptide ester;R.sub.3 is H, CH.sub.3 or CHO;when R.sub.5 and R.sub.6 are taken separately, R.sub.6 is H and one of R.sub.4 and R.sub.5 is ethyl and the other is H or OH;when R.sub.5 and R.sub.6 are taken together with the carbon atoms to which they are attached, they form an oxirane ring and R.sub.4 is ethyl, and A is a residue of a bifunctional organic derivative of the maleoylamino acid or maleoyl peptide or maleoylphenoxy type.