Abstract: A Bacillus cell contains a mutation in the epr gene resulting in inhibition of the production by the cell of the proteolytically active epr gene product; the cell may further contain mutations in the genes encoding proteolytically active residual protease I (RP-I) and proteolytically active residual protease II (RP-II) (mpr).
Type:
Grant
Filed:
April 15, 1997
Date of Patent:
February 23, 1999
Assignee:
OmniGene Inc.
Inventors:
Alan Sloma, Gerald A. Rufo, Jr., Cathy Faye Rudolph, Barbara J. Sullivan, Janice Pero
Abstract: A Bacillus cell contains a mutation in the epr gene resulting in inhibition of the production by the cell of the proteolytically active epr gene product; the cell may further contain mutations in the genes encoding proteolytically active residual protease I (RP-I) and proteolytically active residual protease II (RP-II).
Type:
Grant
Filed:
September 7, 1990
Date of Patent:
April 15, 1997
Assignee:
Omnigene, Inc.
Inventors:
Alan Sloma, Gerald A. Rufo, Jr., Cathy F. Rudolph, Barbara J. Sullivan, Janice Pero
Abstract: A Bacillus cell contains a mutation in the epr gene resulting in inhibition of the production by the cell of the proteolytically active epr gene product; the cell may further contain mutations in the genes encoding proteolytically active residual protease I (bpr) and proteolytically active residual protease II (RP-II).
Type:
Grant
Filed:
August 12, 1994
Date of Patent:
December 31, 1996
Assignee:
Omnigene, Inc.
Inventors:
Alan Sloma, Gerald A. Rufo, Jr., Cathy F. Rudolph, Barbara J. Sullivan, Janice Pero
Abstract: A Bacillus cell containing a mutation in the residual protease III (rp-III) gene resulting in the inhibition of the production by the cell of proteolytically active RP-III.
Type:
Grant
Filed:
March 19, 1991
Date of Patent:
March 15, 1994
Assignee:
Omnigene, Inc.
Inventors:
Alan Sloma, Gerald A. Rufo, Jr., Janice Pero
Abstract: An optical detection method for detecting specific ligands in an immunoassay is formed by diffracting a beam of light through slits formed in a mask and thererby forming an interference pattern. The diffracted light of one of the slits is distributed by an assay having a ligand which when reacted with anti-ligand changes the optical characteristics of the assay thereby changing the interference pattern in a concentration dependent manner.
Abstract: Engineered DNA encoding a pre-protein which comprises a Streptomyces chitinase signal sequence and a desired mature protein. Preferably, the signal sequence is from the S. plicatus endochitinase gene. The engineered DNA is included in a host organism causing the host to produce and secrete the mature protein. Where the mature protein is a chitinase, the invention is used in methods of controlling chitinase-sensitive pests.
Type:
Grant
Filed:
February 1, 1990
Date of Patent:
February 23, 1993
Assignee:
Omnigene, Inc.
Inventors:
Karen M. Overbye, Janice Pero, Phillips W. Robbins
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