Abstract: The system for management of rack and tube positions for clinical chemistry laboratories includes tubes (10) capable of containing human biological material, a rack (20) configured for receiving and/or holding the tubes (10) to be stocked, a supporting base (30) configured for supporting the rack (20) thereon, a reader (50) configured for reading an identifier (RID) of the rack (20) to be put onto the supporting base (30) and an identifier (TID) of the tube to be put into the rack (20), a camera (40) for detecting the rack (20) on the supporting base (30), and at least one of the tubes (10) into the rack (20), a processing unit (60) for mapping the detected rack (20) into a plurality of allowed positions (Pi) and the detected tube (10) into a tube position (P) included in the plurality of allowed positions (Pi).