Abstract: The present invention relates to methods and compositions used to reduce or prevent organ, tissue and cellular damage induced by irradiation exposure, such as radiodermatitis and radio mucositis. The compositions according to the invention comprise one or more inhibitors of plasminogen or one or more inhibitors of a component of the plasminogen activating pathway.
Type:
Application
Filed:
September 22, 2016
Publication date:
October 4, 2018
Applicant:
OMNIO AB
Inventors:
Tor NY, Mahsa FALLAH, Malgorzata WILCZYNSKA, Michael BLOMQUIST, Mikael JOHANSSON
Abstract: The present invention relates to the use of plasminogen and plasmin as agents for enhancing healing of tympanic membrane perforations or other wounds, and for reducing scars or necrotic tissue forming during wound healing. The invention also relates to a method for screening of compounds which enhance wound healing by evaluating the healing of tympanic membrane perforations in an animal model.
Type:
Application
Filed:
October 18, 2005
Publication date:
February 22, 2007
Applicant:
Omnio AB
Inventors:
Tor Ny, Jinan Li, Sten Hellstrom, Per-Olof Eriksson
Abstract: The present invention relates to the use of plasminogen and plasmin as agents for enhancing healing of tympanic membrane perforations or other wounds, and for reducing scars or necrotic tissue forming during wound healing. The invention also relates to a method for screening of compounds which enhance wound healing by evaluating the healing of tympanic membrane perforations in an animal model.
Type:
Grant
Filed:
September 5, 2002
Date of Patent:
June 27, 2006
Assignee:
Omnio AB
Inventors:
Tor Ny, Jinan Li, Sten Hellstrom, Per-Olof Eriksson
Abstract: The present invention relates to the use of plasminogen and plasmin as agents for enhancing healing of tympanic membrane perforations or other wounds, and for reducing scars or necrotic tissue forming during wound healing. The invention also relates to a method for screening of compounds which enhance wound healing by evaluating the healing of tympanic membrane perforations in an animal model.
Type:
Application
Filed:
September 5, 2002
Publication date:
August 7, 2003
Applicant:
OMNIO AB
Inventors:
Tor Ny, Jinan Li, Sten Hellstrom, Per-Olof Eriksson
Abstract: Novel drug targets for the treatment or prevention of arthritis are provided. Screening methods for inhibitors of the plasminogen-activation pathway, such as, for example, antagonists or inhibitors of the urokinase-type plasminogen activator (uPA), plasminogen-activator type 1 (PAI-1), the urokinase activator receptor (uPAR), and plasmin, are used to identify novel drugs for treating or preventing the progression of arthritis. Such screening methods, or methods for evaluating whether a drug is useful for treating or preventing arthritis, can also be conducted in animal models described herein. Methods of treating or preventing such diseases are also provided.