Patents Assigned to Omniox, Inc.
  • Modulation of tumor immunity by protein-mediated Odelivery
    Patent number: 12285463
    Abstract: The invention provides methods to modulate hypoxia-mediated tumor immunity by administration of an O2 carrier polypeptide (e.g., an H-NOX protein). The methods of the invention target both hypoxia inducible factor 1 alpha (HIF-1?) pathways and non-HIF-1? pathways of tumor immunity. Such methods are useful in the treatment of a wide variety of cancers and may be used alone or in combination with other anti-cancer therapies.
    Type: Grant
    Filed: December 10, 2021
    Date of Patent: April 29, 2025
    Assignee: Omniox, Inc.
    Inventors: Stephen P. L. Cary, Ana Krtolica, Natacha Le Moan, Jonathan A Winger, Kevin G. Leong
  • Polymeric forms of H-NOX proteins
    Patent number: 11987614
    Abstract: The invention provides polymeric H-NOX proteins for the delivery of oxygen with longer circulation half-lives compared to monomeric H-NOX proteins. Polymeric H-NOX proteins extravasate into and preferentially accumulate in tumor tissue for sustained delivery of oxygen. The invention also provides the use of H-NOX proteins as radiosensitizers for the treatment of brain cancers.
    Type: Grant
    Filed: August 9, 2021
    Date of Patent: May 21, 2024
    Assignee: OMNIOX, INC.
    Inventors: Gregory Kapp, Laura Serwer, Natacha Le Moan, Stephen P. L. Cary
  • Polymeric forms of H-NOX proteins
    Patent number: 11117952
    Abstract: The invention provides polymeric H-NOX proteins for the delivery of oxygen with longer circulation half-lives compared to monomeric H-NOX proteins. Polymeric H-NOX proteins extravasate into and preferentially accumulate in tumor tissue for sustained delivery of oxygen. The invention also provides the use of H-NOX proteins as radiosensitizers for the treatment of brain cancers.
    Type: Grant
    Filed: July 17, 2020
    Date of Patent: September 14, 2021
    Assignee: OMNIOX, INC.
    Inventors: Gregory Kapp, Laura Serwer, Natacha Le Moan, Stephen P. L. Cary
  • MODULATION OF HYPOXIA ASSOCIATED WITH STROKE
    Publication number: 20210121521
    Abstract: The invention provides H-NOX proteins for the delivery of oxygen to hypoxic tissue following stroke. H-NOX proteins extravasate into hypoxic penumbra associated with stroke and preferentially accumulate for sustained delivery of oxygen to the hypoxic tissue to ameliorate adverse affects of stroke related hypoxia. In some embodiments, the H-NOX comprises PEGylated H-NOX and non-PEGylated H-NOX.
    Type: Application
    Filed: December 23, 2020
    Publication date: April 29, 2021
    Applicant: Omniox, Inc.
    Inventors: Natacha Le Moan, Ana Krtolica, Philberta Leung, Stephen P. L. Cary
  • POLYMERIC FORMS OF H-NOX PROTEINS
    Publication number: 20210002351
    Abstract: The invention provides polymeric H-NOX proteins for the delivery of oxygen with longer circulation half-lives compared to monomeric H-NOX proteins. Polymeric H-NOX proteins extravasate into and preferentially accumulate in tumor tissue for sustained delivery of oxygen. The invention also provides the use of H-NOX proteins as radiosensitizers for the treatment of brain cancers.
    Type: Application
    Filed: July 17, 2020
    Publication date: January 7, 2021
    Applicant: Omniox, Inc.
    Inventors: Gregory Kapp, Laura Serwer, Natacha Le Moan, Stephen P. L. Cary
  • Polymeric forms of H-NOX proteins
    Patent number: 10766947
    Abstract: The invention provides polymeric H-NOX proteins for the delivery of oxygen with longer circulation half-lives compared to monomeric H-NOX proteins. Polymeric H-NOX proteins extravasate into and preferentially accumulate in tumor tissue for sustained delivery of oxygen. The invention also provides the use of H-NOX proteins as radiosensitizers for the treatment of brain cancers.
    Type: Grant
    Filed: June 24, 2019
    Date of Patent: September 8, 2020
    Assignee: Omniox, Inc.
    Inventors: Gregory Kapp, Laura Serwer, Natacha Le Moan, Stephen P. L. Cary
  • MODULATION HYPOXIA ASSOCIATED WITH STROKE
    Publication number: 20200276265
    Abstract: The invention provides H—NOX proteins for the delivery of oxygen to hypoxic tissue following stroke. H—NOX proteins extravasate into hypoxic penumbra associated with stroke and preferentially accumulate for sustained delivery of oxygen to the hypoxic tissue to ameliorate adverse affects of stroke related hypoxia. In some embodiments, the H—NOX comprises PEGylated H—NOX and non-PEGylated H—NOX.
    Type: Application
    Filed: February 16, 2017
    Publication date: September 3, 2020
    Applicant: Omniox, Inc.
    Inventors: Natacha Le Moan, Ana Krtolica, Philberta Leung, Stephen P.L. Cary
  • POLYMERIC FORMS OF H-NOX PROTEINS
    Publication number: 20200017574
    Abstract: The invention provides polymeric H-NOX proteins for the delivery of oxygen with longer circulation half-lives compared to monomeric H-NOX proteins. Polymeric H-NOX proteins extravasate into and preferentially accumulate in tumor tissue for sustained delivery of oxygen. The invention also provides the use of H-NOX proteins as radiosensitizers for the treatment of brain cancers.
    Type: Application
    Filed: June 24, 2019
    Publication date: January 16, 2020
    Applicant: Omniox, Inc.
    Inventors: Gregory Kapp, Laura Serwer, Natacha Le Moan, Stephen P. L. Cary
  • Polymeric forms of H-NOX proteins
    Patent number: 10385116
    Abstract: The invention provides polymeric H-NOX proteins for the delivery of oxygen with longer circulation half-lives compared to monomeric H-NOX proteins. Polymeric H-NOX proteins extravasate into and preferentially accumulate in tumor tissue for sustained delivery of oxygen. The invention also provides the use of H-NOX proteins as radiosensitizers for the treatment of brain cancers.
    Type: Grant
    Filed: January 7, 2013
    Date of Patent: August 20, 2019
    Assignee: Omniox, Inc.
    Inventors: Gregory Kapp, Laura Serwer, Natacha Le Moan, Stephen P. L. Cary
  • POLYMERIC FORMS OF H-NOX PROTEINS
    Publication number: 20160185839
    Abstract: The invention provides polymeric H-NOX proteins for the delivery of oxygen with longer circulation half-lives compared to monomeric H-NOX proteins. Polymeric H-NOX proteins extravasate into and preferentially accumulate in tumor tissue for sustained delivery of oxygen. The invention also provides the use of H-NOX proteins as radiosensitizers for the treatment of brain cancers.
    Type: Application
    Filed: January 7, 2013
    Publication date: June 30, 2016
    Applicant: Omniox, Inc.
    Inventors: Gregory KAPP, Laura SERWER, Natacha LE MOAN, Stephen P.L. CARY