Abstract: The present invention is directed to compounds useful in stabilizing thrombin activity, thrombin compositions comprising the compounds, methods of using the compounds and methods of identifying compounds capable of stabilizing thrombin activity. The compounds are preferably isolated peptides comprising or interacting with the gamma loop of thrombin.
Abstract: Provided herein are stable liquid sealant formulations comprising fibrin monomers and a reversible fibrin polymerization blocking agent, methods of preparing and using the formulations.
Type:
Grant
Filed:
March 23, 2017
Date of Patent:
July 23, 2019
Assignee:
Omrix Biopharmaceuticals Ltd.
Inventors:
Yair Pilpel, Ashley Deanglis, Yuri Zherdev, Sivan Doron, Israel Nur
Abstract: Apparatuses and methods for delivery of fluid materials, particularly multi-part fluid materials, including modular apparatuses in which various components are maintained separately until ready for use. Each fluid component is maintained in a separate housing until mixing of the fluid components is desired. Maintaining components separately until use allows for proper filling, sterilization, packaging and storing until use.
Abstract: The present invention is directed to compounds, methods for stabilizing thrombin activity with a thrombin binding oligonucleotide and to stabilized thrombin. The thrombin binding oligonucleotide is capable of inhibiting thrombin activity whereby the inhibition can be reversed with an antisense oligonucleotide.
Abstract: The present invention relates to improved hemostatic compositions comprising cellulose-based fibers supplemented with compounds, preparation and use thereof.
Type:
Grant
Filed:
November 8, 2016
Date of Patent:
November 27, 2018
Assignees:
Omrix Biopharmaceuticals Ltd., Ethicon, Inc.
Inventors:
Erez Ilan, Omri Faingold, Nataly Freizus, Ronen Eavri, Dwayne Looney, Sridevi Dhanaraj, James Galloway, Walter Danker
Abstract: The invention relates to a hemostatic composition comprising a mixture of cellulose-based short and long fibers, preparation and use thereof.
Type:
Grant
Filed:
November 8, 2016
Date of Patent:
November 27, 2018
Assignees:
Omrix Biopharmaceuticals Ltd., Ethicon, Inc.
Inventors:
Erez Ilan, Omri Faingold, Nataly Freizus, Ronen Eavri, Dwayne Looney, Sridevi Dhanaraj, James Galloway, Walter Danker
Abstract: The present invention is directed to compounds useful in stabilizing thrombin activity, thrombin compositions comprising the compounds, methods of using the compounds and methods of identifying compounds capable of stabilizing thrombin activity. The compounds are preferably isolated peptides comprising or interacting with the gamma loop of thrombin.
Abstract: The invention relates to a device suitable for application of a curable fluid composition to encircle a bodily organ. The device comprises a monolithic piece of a flexible material having a length dimension with an inner surface and an outer surface, a first end and a second end, a width dimension, and two spaced-apart sides, wherein a portion of the length dimension proximal to the first end is configured to contact a portion of the length dimension proximal to the second end, the inner surface defining a hollow area between the two spaced-apart sides; and at least one inlet providing fluid communication between the outer surface and the inner surface, for introduction of the fluid into the hollow area.
Abstract: A device for administering injections includes a housing having an upper end, a lower end including a bottom surface with an injection needle opening, and an axis extending between the upper and lower ends. The device includes a needle housing with an injection needle. The needle housing is disposed within the housing for moving between a retracted position and an extended position. The device has an injection actuator for commencing an injection cycle including a first stage in which the needle housing and said plunger base are coupled together and move in a first direction along the axis and a second stage in which the needle housing and the plunger base are decoupled from one another so that the plunger base is free to move away from the needle housing in a second direction that is opposite the first direction.
Abstract: The presently disclosed subject matter relates to an addition to a medical applicator in general and in particular to an addition to a medical applicator for applying on a surface a curable liquid substance having multi components.
Abstract: Provided is a method for purifying ?-thrombin and for quantifying ?-thrombin and its degradation polypeptides in a liquid proteinatious solution. The method employs a one-step anion exchange chromatography method. The method allows purification and/or quantification of a homogenous post-translationally modified ?-thrombin. The method can also be used for purification and/or quantification of ?-thrombin.
Type:
Grant
Filed:
February 24, 2016
Date of Patent:
September 4, 2018
Assignee:
Omrix Biopharmaceuticals Ltd.
Inventors:
Tamar Auerbach-Nevo, Nadav Orr, Israel Nur
Abstract: The invention relates to a prosthetic for repairing an opening or a defect in a soft tissue, to its preparation and use. The prosthetic of the invention comprises a substrate viscerally-coated with stabilized and non-completely dry fibrin. The prosthetic displays reduced postoperative complications following its implantation.
Type:
Grant
Filed:
September 21, 2009
Date of Patent:
August 7, 2018
Assignee:
Omrix Biopharmaceuticals Ltd.
Inventors:
Eyal Sheetrit, Israel Nur, Liliana Bar, Lior Weissman
Abstract: Specific peptides have been discovered that mimic an idiotype of an autoantibody. Such peptides may be formed into polymers. The peptides may be used in pharmaceutical compositions for the treatment of an autoimmune disease together with a pharmaceutically acceptable excipient.
Type:
Grant
Filed:
May 26, 2013
Date of Patent:
August 7, 2018
Assignee:
OMRIX BIOPHARMACEUTICALS LTD.
Inventors:
Israel Nur, Yehuda Shoenfeld, Miri Blank
Abstract: The invention relates to a viral-safe platelet extract, to its preparation and use. The extract comprises a mixture of biologically active platelet derived factors. Advantageously, the extract comprises a balanced proportion of the factors and is non-clottable.
Type:
Grant
Filed:
November 5, 2013
Date of Patent:
April 17, 2018
Assignee:
Omrix Biopharmaceuticals Ltd.
Inventors:
Lior Weissman, Nina Raver-Shapira, Israel Nur, Oleg Belyaev
Abstract: Provided is a spray drying apparatus comprising a spray nozzle comprising a spray nozzle tip at the distal end of the spray nozzle, a liquid conduit for guiding a liquid to be spray-dried out through the spray nozzle tip, an atomizing component for producing a spray of droplets from the liquid exiting the spray nozzle; a drying gas conduit comprising an outlet for directing a drying gas to dry the spray of droplets; and a drying gas deflector positioned so as to deflect a flow of the drying gas away from the spray nozzle tip.
Abstract: A method is described for the measurement of thrombin activity in the presence of fibrinogen, or for the measurement of the functionality of fibrinogen in the presence of thrombin.
Abstract: The invention relates to a viral inactivated biological liquid or dry mixture and to its preparation. Principally, the invention relates, but is not limited, to a mixture derived from a platelet source.
Type:
Grant
Filed:
December 19, 2013
Date of Patent:
January 16, 2018
Assignee:
Omrix Biopharmaceuticals Ltd.
Inventors:
Lior Weissman, Itai Podoler, Israel Nur, Tamara Byk-Tennenbaum
Abstract: Provided herein are stable liquid sealant formulations comprising fibrin monomers and a reversible fibrin polymerization blocking agent, methods of preparing and using the formulations.
Type:
Grant
Filed:
December 4, 2014
Date of Patent:
November 14, 2017
Assignees:
Omrix Biopharmaceuticals Ltd., Ethicon, Inc.
Inventors:
Yair Pilpel, Ashley Deanglis, Yuri Zherdev, Sivan Doron, Israel Nur
Abstract: The invention relates to an immunoglobulin composition reduced in thrombogenic agents and to methods for its preparation. One method comprises subjecting an immunoglobulin containing solution to a negative cation exchanger chromatography at a pH in the range of higher than 3.8 to equal to or lower than 5.3. The solution can also be subjected to a negative anion exchanger chromatography at a pH in the range of 7 to 8.2.
Type:
Grant
Filed:
April 3, 2015
Date of Patent:
October 24, 2017
Assignee:
Omrix Biopharmaceuticals Ltd.
Inventors:
Roni Mintz, Oleg Belyaev, Israel Nur, Liliana Bar, Roberto Meidler