Patents Assigned to OMT, Inc.
  • Polynucleotides encoding rodent antibodies with human idiotypes and animals comprising same
    Patent number: 9475859
    Abstract: The invention relates to polynucleotides, particularly chimeric polynucleotides useful for optimal production of functional immunoglobulins with human idiotypes in rodents. The invention further relates to rodents comprising such polynucleotides.
    Type: Grant
    Filed: October 17, 2014
    Date of Patent: October 25, 2016
    Assignee: OMT, Inc.
    Inventors: Marianne Bruggemann, Roland Buelow, Michael J. Osborn, Biao Ma
  • Methods for producing transgenic rodents having recombinant immunoglobulin loci
    Patent number: 8907157
    Abstract: The invention provides methods for the production of transgenic animals comprising a recombinant Ig locus, as well as transgenic antibodies derived therefrom. The methods involve meganuclease cleavage-stimulated homologous recombination in mammalian embryos.
    Type: Grant
    Filed: February 5, 2010
    Date of Patent: December 9, 2014
    Assignee: OMT, Inc.
    Inventor: Roland Buelow
  • Germ cells having inactivated endogenous immunoglobulin genes, and transgenic animals derived therefrom
    Patent number: 8703485
    Abstract: The invention relates to transgenic animals lacking endogenous Ig and capable of producing transgenic antibodies, as well as methods of making the same. The invention further relates to methods for producing transgenic antibodies in such animals, and transgenic antibodies so produced.
    Type: Grant
    Filed: May 30, 2008
    Date of Patent: April 22, 2014
    Assignee: OMT, Inc.
    Inventor: Roland Buelow
  • Compositions and Methods for Inhibiting Endogenous Immunoglobulin Genes and Producing Transgenic Human Idiotype Antibodies
    Publication number: 20120090041
    Abstract: The invention relates to transgenic animals lacking endogenous Ig and capable of producing transgenic antibodies, as well as methods of making the same. The invention further relates to methods for producing transgenic antibodies in such animals, and transgenic antibodies so produced.
    Type: Application
    Filed: July 27, 2011
    Publication date: April 12, 2012
    Applicant: OMT, INC.
    Inventor: ROLAND BUELOW
  • Compositions and Methods for Producing Transgenic Mammals Having Recombinant Immunoglobulin Loci
    Publication number: 20100212035
    Abstract: The invention provides methods for the production of transgenic animals comprising a recombinant Ig locus, as well as transgenic antibodies derived therefrom. The methods involve meganuclease cleavage-stimulated homologous recombination in mammalian embryos.
    Type: Application
    Filed: February 5, 2010
    Publication date: August 19, 2010
    Applicant: OMT, Inc.
    Inventor: Roland BUELOW
  • COMPOSITIONS AND METHODS FOR INHIBITING ENDOGENOUS IMMUNOGLOBULIN GENES AND PRODUCING TRANSGENIC HUMAN IDIOTYPE ANTIBODIES
    Publication number: 20090098134
    Abstract: The invention relates to transgenic animals lacking endogenous Ig and capable of producing transgenic antibodies, as well as methods of making the same. The invention further relates to methods for producing transgenic antibodies in such animals, and transgenic antibodies so produced.
    Type: Application
    Filed: May 30, 2008
    Publication date: April 16, 2009
    Applicant: OMT, Inc.
    Inventor: Roland BUELOW