Abstract: The present invention is directed to methods of inhibiting p97 and compounds and compositions useful in such methods. Diseases and conditions the can be treated with the compounds and compositions of the invention include, but are not limited to, cancer and neurodegenerative disorders susceptible to treatment by inhibition of p97.

Abstract: A press-fit terminal inserted into through hole of a circuit board along insertion direction includes a base portion extending in insertion direction, distal end portion, and two deformable portions. The distal end portion is on a front side to base portion in insertion direction and includes distal end portion side corner portions. The two deformable portions connect base portion and distal end portion and are contacted with an inner wall of through hole and elastically deformed. The two deformable portions include deformable portion side corner portions and deformable portion side corner portions include outer deformable portion side corner portions on outer side in direction crossing insertion direction. The two deformable portions include easy deformable portions, in portions having outer deformable portion side corner portions with curved surfaces whose radius of curvature RL is greater than a radius of curvature RS of curved surfaces of distal end portion side corner portions.

Abstract: Systems and methods for autonomous program management include a device which may transmit data to a client in response to a first request from the client. The data may include a response to the first request and a copy of data available to the device corresponding to the first request or the client. The device may receive a second request including the copy of data from the client. The device may determine that the second request is from an autonomous program rather than a user of the client based on the copy of data from the second request. The device may block at least one subsequent request from the client in response to the determination that the second request is from an autonomous program.

Abstract: Techniques, a system, and architecture are disclosed for top side transistor heat dissipation. The heat dissipation is done through single crystal epitaxially grown layer such as AlN. The architecture may include a back side heat sink to increase thermal dissipation as well. The architecture may further include a pseudomorphic channel layer that is lattice matched to the substrate.

Abstract: A filter apparatus for removing small molecule chemotherapy agents from blood is provided. The filter apparatus comprises a housing with an extraction media comprised of polymer coated carbon cores. Also provided are methods of treating a subject with cancer of an organ or region comprising administering a chemotherapeutic agent to the organ or region, collecting blood laded with chemotherapeutic agent from the isolated organ, filtering the blood laden with chemotherapeutic agent to reduce the chemotherapeutic agent in the blood and returning the blood to the subject.

Abstract: Techniques are provided for fabricating a low profile antenna that operates with increased efficiency. An antenna implementing the techniques according to an embodiment includes a first arm comprising a first spiral portion and a first rectilinear portion, and a second arm comprising a second spiral portion and a second rectilinear portion. The second spiral portion is concentric with the first spiral portion. The antenna further includes an insulator to separate the arms. The insulator and the arms are planar surfaces disposed within a rectangular region. The first rectilinear portion is adjacent to a first and second side of the perimeter of the rectangular region, and the second rectilinear portion is adjacent to a third and fourth side of the perimeter of the region. The antenna is fabricated as a printed circuit board which is mounted on the fuselage of an aircraft, which serves as a ground plane for the antenna.

Abstract: An adeno-associated virus (AAV) vector for inserting a desired nucleic acid into a nucleic acid in a cell, wherein the nucleic acid in the cell comprises a region consisting of a first nucleotide sequence and a region consisting of a second nucleotide sequence in order in a direction from a 5? end to a 3? end, wherein the vector comprises a first gRNA target sequence, a region consisting of a first nucleotide sequence, the desired nucleic acid, a region consisting of a second nucleotide sequence, a second gRNA target sequence, a cell-specific promoter, a sequence encoding a Cas9 nuclease, an RNA polymerase III promoter, a sequence encoding a first gRNA recognizing the first gRNA target sequence and a sequence encoding a second gRNA recognizing the second gRNA target sequence, wherein the vector yields a nucleic acid fragment comprising a region consisting of a first nucleotide sequence, the desired nucleic acid and the region consisting of the second nucleotide sequence by the Cas9 nuclease, wherein a first n

Abstract: A control device of an uninterruptible power supply apparatus turns on a first switch and a second switch and turns off a third switch in an inverter power feed mode, turns on the first and third switches and turns off the second switch in a bypass power feed mode, and executes a lap power feed mode of turning off the first switch and turning on the second and third switches in a switching period in which one mode of the inverter power feed mode and the bypass power feed mode is switched to the other mode.

Abstract: Systems and methods of controlling a state of electronic messaging applications are provided. A system detects a launch of a network application via an embedded browser. The network application is associated with a session identifier of a user. The system identifies one or more electronic messaging applications on a client device of the user. The system transmits, responsive to the launch of the network application associated with the session identifier, an instruction to one or more servers managing the one or more electronic messaging applications to control a state of the one or more electronic messaging applications.

Abstract: Embodiments described herein provide various examples of real-time visual object tracking. In another aspect, a process for performing a local re-identification of a target object which was earlier detected in a video but later lost when tracking the target object is disclosed. This process begins by receiving a current video frame of the video and a predicted location of the target object. The process then places a current search window in the current video frame centered on or in the vicinity of the predicted location of the target object. Next, the process extracts a feature map from an image patch within the current search window. The process further retrieves a set of stored feature maps computed at a set of previously-determined locations of the target object from a set of previously-processed video frames in the video. The process next computes a set of correlation maps between the feature map and each of the set of stored feature maps.

Abstract: An automatic transfer switch includes a first conduction bar selectively coupled with a first power source and a load conduction bar; a second conduction bar selectively coupled with a second power source and the load conduction bar; a first blade assembly electrically coupled to the first conduction bar; and a second blade assembly electrically coupled to the second conduction bar. The first blade assembly is electrically coupled to a first source conduction bar in a closed position, and a first electromagnetic force induced by a first current flowing through the first blade assembly and the first conduction bar repulses the first blade assembly. The second blade assembly is electrically coupled to a second source conduction bar in a closed position, and a second electromagnetic force induced by a second current flowing through the second blade assembly and the second conduction bar repulses the second blade assembly.

Abstract: In this disclosure, collaborative multi-agent-based TST is presented with dedicated intersection controllers that include software agents which read local and remote detection systems and then collaboratively optimize signal timing phases by considering the feedback of all controller agents that may be affected by a change. The disclosure also presents an augmented system which considers network input from handheld remote devices to update certain traffic light phase information and adapt to emerging emergency situations.

Abstract: A system and method for sending instrument data from a sub-surface activity, such as data collection by one or more sensors, to another location, e.g., a satellite, a ground-based location, a vessel, etc., with minimal time exposure and minimal visibility of any system components at the water surface. Exemplary embodiments include a motorized payout-and-retrieval system or device, an air injection device, and a water-level sensor with automation control that together can be used to move a vessel, connected to an antenna, from a position in the water column in which the antenna is below the surface to a higher position in which the antenna is at or above the surface for data transmission.

Abstract: Provided herein is an engineered extracellular vesicle (eEV) and an extracellular vesicle delivery vehicle. The engineered extracellular vesicle is an isolated extracellular vesicle that has a membrane hybridized with lipids. The extracellular vesicle delivery vehicle is a lipid-hybridized extracellular vesicle with a nucleic acid loaded within the core, a multi-layered polyelectrolyte coating deposited around the lipid-hybridized extracellular vesicle and a therapeutic drug complexed to one of the layer of polyelectrolyte coatings. Also provided are methods for preparing an engineered extracellular vesicle, for preparing an extracellular vesicle delivery vehicle, for treating a pathophysiological condition in a subject, and for co-delivering a nucleic acid and a therapeutic drug to a cell of interest.

Abstract: A method of normalizing detector elements in an imaging system is described herein. The method includes a line source that is easier to handle for a user, and decouples the normalization of the detector elements into a transaxial domain and an axial domain in order to isolate errors due to positioning of the line source. Additional simulations are performed to augment the real scanner normalization. A simulation of a simulated line source closely matching the real line source can be performed to isolate errors due to physical properties of the crystals and position of the crystals in the system, wherein the simulated detector crystals are otherwise modeled uniformly. A simulation of a simulated cylinder source can be performed to determine errors due to other effects stemming from gaps between the detector crystals.

Abstract: The present invention provides: a compound superconducting twisted wire in which non-adhesiveness between compound superconducting strands or separation easiness after adhesion is improved while a strength against tension is improved to a degree to be equivalent to or stronger than that of a conventional compound superconducting twisted wire; and a rewinding method thereof.

Abstract: A containerized application management system and management method, applied to a network, are provided. The system includes a master node, a first worker node with a first change tracking program pod deployed thereon, and a second worker node with a second change tracking program pod deployed thereon. The method includes: receiving a pod create request, and sending a content mutate request by the master node when content of the pod create request meets a preset condition; receiving the content mutate request and changing the content to form a mutated pod create request, and forwarding the mutated pod create request by the master node to the first or second worker node; and enabling the first or second worker node to create a pod according to the mutated pod create request. The pod includes an initial container and at least one container.

Abstract: A simulation device includes an outer frame and an inner frame. The outer frame is fixed to a floor surface and the inner frame is slideably interfaced to the outer frame. The inner frame has an inner frame axis. A hydraulic cylinder is interfaced between the outer frame and the inner frame. Operation of the hydraulic cylinder slides the inner frame with respect to the outer frame along the inner frame axis. A yaw platform is interfaced to the inner frame at one end at a pivot and at a distal opposing end by two or more bearings. The yaw platform has a yaw platform axis. Operation of a yaw motor or a yaw hydraulic ram interfaced between the yaw platform and the inner frame causes the yaw platform to change an angle between the inner frame axis and the yaw platform axis, providing simulation of yaw (loss of control).

Abstract: A deep learning (DL) convolution neural network (CNN) reduces noise in positron emission tomography (PET) images, and is trained using a range of noise levels for the low-quality images having high noise in the training dataset to produce uniform high-quality images having low noise, independently of the noise level of the input image. The DL-CNN network can be implemented by slicing a three-dimensional (3D) PET image into 2D slices along transaxial, coronal, and sagittal planes, using three separate 2D CNN networks for each respective plane, and averaging the outputs from these three separate 2D CNN networks. Feature-oriented training can be implemented by segmenting each training image into lesion and background regions, and, in the loss function, applying greater weights to voxels in the lesion region. Other medical images (e.g. MRI and CT) can be used to enhance resolution of the PET images and provide partial volume corrections.

Abstract: The systems, methods, and apparatuses described herein provide integrated weather forecast products designed to assist operations managers with operational decision-making related to a designated event or set of events. The present disclosure provides a way to process weather data from various sources and in diverse data formats containing varying spatial resolutions and temporal resolutions, in order to generate an integrated and cohesive weather projection product such that the weather projection product is continuous in both spatial and temporal domains, subject to data availability, relative to a designated event or set of events.