Patents Assigned to On Target Laboratories, LLC
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Patent number: 11964965Abstract: The present disclosure relates to synthesizing and utilizing fluorescent dye compounds or pharmaceutically acceptable salts thereof. Conjugation of amino acid groups to the fluorescent dyes increase specificity and detection of the compound. Methods of manufacture and synthesis of the compounds for use thereof in diagnostic imaging are contemplated.Type: GrantFiled: May 20, 2020Date of Patent: April 23, 2024Assignee: On Target Laboratories, LLCInventors: Sumith A. Kularatne, Pravin Gagare
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Patent number: 11484607Abstract: The present disclosure relates to prostate specific membrane antigen (PSMA) targeted compounds conjugated to near-infra red (NIR) dyes and methods for their therapeutic and diagnostic use. More specifically, this disclosure provides compounds and methods for diagnosing and treating diseases associated with cells and/or vasculature expressing prostate specific membrane antigen (PSMA), such as prostate cancer and related diseases. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.Type: GrantFiled: September 23, 2020Date of Patent: November 1, 2022Assignee: On Target Laboratories, LLCInventor: Sumith A Kularatne
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Patent number: 10842887Abstract: The present disclosure relates to prostate specific membrane antigen (PSMA) targeted compounds conjugated to near-infra red (NIR) dyes and methods for their therapeutic and diagnostic use. More specifically, this disclosure provides compounds and methods for diagnosing and treating diseases associated with cells and/or vasculature expressing prostate specific membrane antigen (PSMA), such as prostate cancer and related diseases. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.Type: GrantFiled: September 10, 2018Date of Patent: November 24, 2020Assignee: On Target Laboratories, LLCInventors: Sumith A Kularatne, Mini Thomas
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Patent number: 10786580Abstract: Compounds are described herein where CCK2R targeting ligands are attached to an imaging agent through a linker. The compounds can be used in the detection, diagnosis, imaging and treatment of cancer.Type: GrantFiled: September 8, 2017Date of Patent: September 29, 2020Assignee: On Target Laboratories, LLCInventors: Sumith A. Kularatne, Pravin Gagare, Mohammad Noshi
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Patent number: 10746741Abstract: The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a ligand that binds to the active site of carbonic anhydrase, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid, amide, ureido, or polyethylene glycol derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.Type: GrantFiled: December 20, 2019Date of Patent: August 18, 2020Assignee: On Target Laboratories, LLCInventors: Sumith A Kularatne, Pravin Gagare, Ananda Kumar Kanduluru
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Patent number: 10676487Abstract: The present invention describes new compounds that are useful for image-guided surgery and photodynamic therapy. In particular the compounds may be targeted to the nucleus or the mitochondria after compounds were delivered to diseased tissues such as cancer using a ligand that target receptor that express on the diseased tissue and followed by receptor mediated endocytosis and provide effective activity against cancer cells as well as other disorders. Methods and compositions for use of the same are described.Type: GrantFiled: September 6, 2016Date of Patent: June 9, 2020Assignee: On Target Laboratories, LLCInventors: Sumith A. Kularatne, Pravin Gagare, Carrie H. Myers
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Patent number: 10557854Abstract: The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a ligand that binds to the active site of carbonic anhydrase, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid, amide, ureido, or polyethylene glycol derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.Type: GrantFiled: March 16, 2017Date of Patent: February 11, 2020Assignee: On Target Laboratories, LLCInventors: Sumith A Kularatne, Pravin Gagare, Ananda Kumar Kanduluru
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Patent number: 10456482Abstract: The present disclosure relates to prostate specific membrane antigen (PSMA) targeted compounds conjugated to near-infra red (NIR) dyes and methods for their therapeutic and diagnostic use. More specifically, this disclosure provides compounds and methods for diagnosing and treating diseases associated with cells and/or vasculature expressing prostate specific membrane antigen (PSMA), such as prostate cancer and related diseases. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.Type: GrantFiled: June 15, 2017Date of Patent: October 29, 2019Assignee: On Target Laboratories, LLCInventors: Sumith A. Kularatne, Pravin Gagare
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Patent number: 10308606Abstract: The present disclosure relates to prostate specific membrane antigen (PSMA) targeted compounds conjugated to near-infra red (NIR) dyes and methods for a method for synthesizing a compound of the formula:Type: GrantFiled: September 8, 2017Date of Patent: June 4, 2019Assignee: On Target Laboratories, LLCInventors: Sumith A. Kularatne, Pravin Gagare
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Patent number: 9968691Abstract: The present disclosure relates to prostate specific membrane antigen (PSMA) targeted compounds conjugated to near-infra red (NIR) dyes and methods for their therapeutic and diagnostic use. More specifically, this disclosure provides compounds and methods for diagnosing and treating diseases associated with cells and/or vasculature expressing prostate specific membrane antigen (PSMA), such as prostate cancer and related diseases. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.Type: GrantFiled: June 14, 2017Date of Patent: May 15, 2018Assignee: On Target Laboratories, LLCInventors: Sumith A. Kularatne, Pravin Gagare, Carrie Myers
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Patent number: 9808538Abstract: The present disclosure relates to prostate specific membrane antigen (PSMA) targeted compounds conjugated to near-infra red (NIR) dyes and methods for their therapeutic and diagnostic use. More specifically, this disclosure provides compounds and methods for diagnosing and treating diseases associated with cells and/or vasculature expressing prostate specific membrane antigen (PSMA), such as prostate cancer and related diseases. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.Type: GrantFiled: November 10, 2015Date of Patent: November 7, 2017Assignee: On Target Laboratories, LLCInventors: Sumith A. Kularatne, Philip S. Low, Pravin Gagare, Carrie Myers
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Patent number: 9801956Abstract: The present disclosure relates to prostate specific membrane antigen (PSMA) targeted compounds conjugated to near-infra red (NIR) dyes and methods for their therapeutic and diagnostic use. More specifically, this disclosure provides compounds and methods for diagnosing and treating diseases associated with cells and/or vasculature expressing prostate specific membrane antigen (PSMA), such as prostate cancer and related diseases. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.Type: GrantFiled: November 12, 2015Date of Patent: October 31, 2017Assignee: On Target Laboratories, LLCInventors: Sumith A. Kularatne, Philip S. Low, Pravin Gagare
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Publication number: 20140275533Abstract: Methods of synthesis and compositions of use for compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof.Type: ApplicationFiled: October 4, 2013Publication date: September 18, 2014Applicant: On Target Laboratories, LLCInventors: Sumith A. Kularatne, Pravin Gagare, Mohammad Noshi