Abstract: The present application provides methods for preparing soluble lipidated ligand agents comprising a ligand entity and a lipid entity, and in some embodiments, provides relevant parameters of each of these components, thereby enabling appropriate selection of components to assemble active agents for any given target of interest.
Type:
Grant
Filed:
January 11, 2019
Date of Patent:
February 22, 2022
Assignees:
On Target Therapeutics LLC, Trustees of Tufts College, Tufts Medical Center
Inventors:
Charles Cohen, Krishna Kumar, Jamie Raudensky Doyle, Alan S. Kopin
Abstract: The present disclosure relates to, among other things, compositions and methods for treating an inflammatory condition including, but not limited to, ocular inflammation, dry eye disease, and ocular neuropathic pain. One aspect of the present disclosure relates to a composition comprising (a) chemerin or a fragment or analog thereof and (b) a lipid entity linked to the chemerin or fragment or analog thereof.
Type:
Grant
Filed:
January 23, 2017
Date of Patent:
December 14, 2021
Assignees:
On Target Therapeutics LLC, Trustees of Tufts College, Tufts Medical Center
Inventors:
Charles Cohen, Krishna Kumar, Alan S. Kopin, Benjamin N. Harwood, Venkata S. Raman, Pedram Hamrah
Abstract: The present application provides methods for preparing soluble lipidated ligand agents comprising a ligand entity and a lipid entity, and in some embodiments, provides relevant parameters of each of these components, thereby enabling appropriate selection of components to assemble active agents for any given target of interest.
Type:
Grant
Filed:
March 13, 2014
Date of Patent:
March 19, 2019
Assignees:
Tufts Medical Center, Trustees of Tufts College, On Target Therapeutics LLC
Inventors:
Charles Cohen, Krishna Kumar, Jamie Raudensky Doyle, Alan S. Kopin
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