Patents Assigned to Oncgnostics GmbH
  • Risk determination for neoplasia and cancer
    Patent number: 12331360
    Abstract: Methods for the determination of the risk of developing neoplasia in a tissue, preferably anogenital tissue, showing no histopathological indications of neoplasia are described. The method is based on the determination of the methylation status of genomic DNA sequences associated with the genes ZNF671, ZNF154, ZNF776, ASTN1, BRINP2, DLX1, METAP1D and/or DLX2.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: June 17, 2025
    Assignee: Oncgnostics GmbH
    Inventors: Matthias Durst, Ingo B. Runnebaum, Martina Schmitz, Alfred Hansel
  • Method for early diagnosis of carcinomas of the anogenital tract
    Patent number: 9228238
    Abstract: A method for the early diagnosis of carcinomas of the anogenital tract, preferably of the cervical carcinoma, and the preliminary stages thereof is described. The method is based on the determination of the methylation status of segments of the gene regions of ASTN1 (astrotactin 1) and ZNF671 (zinc finger protein 671, transcription factor). A DNA methylation in the promoter region or the 5?-region of these genes is indicative for carcinomas of the anogenital tract or severe preliminary stages thereof. The present invention also relates to kits which permit the conduction of the diagnostic method according to the invention.
    Type: Grant
    Filed: August 29, 2013
    Date of Patent: January 5, 2016
    Assignee: ONCGNOSTICS GMBH
    Inventors: Matthias Dürst, Alfred Hansel, Daniel Steinbach
  • METHOD FOR EARLY DIAGNOSIS OF CARCINOMAS OF THE ANOGENITAL TRACT
    Publication number: 20130344479
    Abstract: A method for the early diagnosis of carcinomas of the anogenital tract, preferably of the cervical carcinoma, and the preliminary stages thereof is described. The method is based on the determination of the methylation status of segments of the gene regions of ASTN1 (astrotactin 1) and ZNF671 (zinc finger protein 671, transcription factor). A DNA methylation in the promoter region or the 5?-region of these genes is indicative for carcinomas of the anogenital tract or severe preliminary stages thereof. The present invention also relates to kits which permit the conduction of the diagnostic method according to the invention.
    Type: Application
    Filed: August 29, 2013
    Publication date: December 26, 2013
    Applicant: Oncgnostics GmbH
    Inventors: Matthias DÜRST, Alfred HANSEL, Daniel STEINBACH
  • Method for early diagnosis of carcinomas of the anogenital tract
    Patent number: 8575326
    Abstract: A method for the early diagnosis of carcinomas of the anogenital tract, preferably of the cervical carcinoma, and the preliminary stages thereof is described. The method is based on the determination of the methylation status of segments of the gene regions of ASTN1 (astrotactin 1) and ZNF671 (zinc finger protein 671, transcription factor). A DNA methylation in the promoter region or the 5?-region of these genes is indicative for carcinomas of the anogenital tract or severe preliminary stages thereof. The present invention also relates to kits which permit the conduction of the diagnostic method according to the invention.
    Type: Grant
    Filed: September 17, 2010
    Date of Patent: November 5, 2013
    Assignee: Oncgnostics GmbH
    Inventors: Matthias Dürst, Alfred Hansel, Daniel Steinbach