Patents Assigned to OncImmune Ltd.
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Patent number: 9719984Abstract: The invention relates to a method of detecting a disease state or disease susceptibility in a mammalian subject which comprises detecting an antibody in a test sample comprising a bodily fluid from said mammalian subject wherein said antibody is a biological marker of a disease state or disease susceptibility, the method comprising: (a) contacting said test sample with a plurality of different amounts of an antigen specific for said antibody, (b) detecting the amount of specific binding between said antibody and said antigen, (c) plotting or calculating a curve of the amount of said specific binding versus the amount of antigen for each amount of antigen used in step (a) and (d) determining the presence or absence of said disease state or disease susceptibility based upon the amount of specific binding between said antibody and said antigen at each different antigen concentration used.Type: GrantFiled: April 7, 2014Date of Patent: August 1, 2017Assignee: ONCIMMUNE LTD.Inventors: John Forsyth Russell Robertson, Anthony Barnes, Andrea Murray, Caroline Chapman
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Patent number: 9714938Abstract: The invention relates to a method of detecting a disease state or disease susceptibility in a mammalian subject which comprises detecting an antibody in a test sample comprising a bodily fluid from said mammalian subject wherein said antibody is a biological marker of a disease state or disease susceptibility, the method comprising: (a) contacting said test sample with a plurality of different amounts of an antigen specific for said antibody, (b) detecting the amount of specific binding between said antibody and said antigen, (c) plotting or calculating a curve of the amount of said specific binding versus the amount of antigen for each amount of antigen used in step (a) and (d) determining the presence or absence of said disease state or disease susceptibility based upon the amount of specific binding between said antibody and said antigen at each different antigen concentration used.Type: GrantFiled: April 7, 2014Date of Patent: July 25, 2017Assignee: ONCIMMUNE LTD.Inventors: John Forsyth Russell Robertson, Anthony Barnes, Andrea Murray, Caroline Chapman
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Patent number: 9696319Abstract: A method of determining the immune response of a mammal to circulating tumor marker proteins is described in which a sample of bodily fluid, for example plasma or serum, is contacted with a panel of two or more distinct tumor marker antigen. The presence of complexes between the tumor marker antigens and any autoantibodies to the antigens present in the sample are detected and provide an indication of an immune response to a circulating tumor marker protein. The method is useful for the diagnosis of cancer, particularly for identifying new or recurrent cancer in an otherwise assymptomatic patient.Type: GrantFiled: January 12, 2012Date of Patent: July 4, 2017Assignee: Oncimmune Ltd.Inventors: John F. R. Robertson, Catherine R. L. Graves, Michael R. Price, Frances M Price
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Patent number: 8927223Abstract: The application generally relates to the field of diagnostic or prognostic assays and in particular relates to assays for the detection of antibodies in a sample comprising patient bodily fluid, wherein such antibodies are used as biological markers of a disease state or disease susceptibility. The assay is based on cross-titration of both the patient bodily fluid to be tested for the antibody and an antigen used to detect the antibody by specific binding.Type: GrantFiled: September 24, 2013Date of Patent: January 6, 2015Assignee: OncImmune Ltd.Inventors: John F. R. Robertson, Andrea Murray, Caroline Chapman, Anthony Barnes
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Publication number: 20140234863Abstract: The invention relates to a method of detecting a disease state or disease susceptibility in a mammalian subject which comprises detecting an antibody in a test sample comprising a bodily fluid from said mammalian subject wherein said antibody is a biological marker of a disease state or disease susceptibility, the method comprising: (a) contacting said test sample with a plurality of different amounts of an antigen specific for said antibody, (b) detecting the amount of specific binding between said antibody and said antigen, (c) plotting or calculating a curve of the amount of said specific binding versus the amount of antigen for each amount of antigen used in step (a) and (d) determining the presence or absence of said disease state or disease susceptibility based upon the amount of specific binding between said antibody and said antigen at each different antigen concentration used.Type: ApplicationFiled: April 7, 2014Publication date: August 21, 2014Applicant: ONCIMMUNE LTD.Inventors: John Forsyth Russell Robertson, Anthony Barnes, Andrea Murray, Caroline Chapman
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Publication number: 20140221245Abstract: The invention relates to a method of detecting a disease state or disease susceptibility in a mammalian subject which comprises detecting an antibody in a test sample comprising a bodily fluid from said mammalian subject wherein said antibody is a biological marker of a disease state or disease susceptibility, the method comprising: (a) contacting said test sample with a plurality of different amounts of an antigen specific for said antibody, (b) detecting the amount of specific binding between said antibody and said antigen, (c) plotting or calculating a curve of the amount of said specific binding versus the amount of antigen for each amount of antigen used in step (a) and (d) determining the presence or absence of said disease state or disease susceptibility based upon the amount of specific binding between said antibody and said antigen at each different antigen concentration used.Type: ApplicationFiled: April 7, 2014Publication date: August 7, 2014Applicant: ONCIMMUNE LTD.Inventors: John Forsyth Russell Robertson, Anthony Barnes, Andrea Murray, Caroline Chapman
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Patent number: 8722339Abstract: The invention relates to a method of detecting a disease state or disease susceptibility in a mammalian subject which comprises detecting an antibody in a test sample comprising a bodily fluid from said mammalian subject wherein said antibody is a biological marker of a disease state or disease susceptibility, the method comprising: (a) contacting said test sample with a plurality of different amounts of an antigen specific for said antibody, (b) detecting the amount of specific binding between said antibody and said antigen, (c) plotting or calculating a curve of the amount of said specific binding versus the amount of antigen for each amount of antigen used in step (a) and (d) determining the presence or absence of said disease state or disease susceptibility based upon the amount of specific binding between said antibody and said antigen at each different antigen concentration used.Type: GrantFiled: May 26, 2006Date of Patent: May 13, 2014Assignee: Oncimmune Ltd.Inventors: John Forsyth Russell Robertson, Anthony Barnes, Andrea Murray, Caroline Chapman
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Publication number: 20140038212Abstract: The application generally relates to the field of diagnostic or prognostic assays and in particular relates to assays for the detection of antibodies in a sample comprising patient bodily fluid, wherein such antibodies are used as biological markers of a disease state or disease susceptibility. The assay is based on cross-titration of both the patient bodily fluid to be tested for the antibody and an antigen used to detect the antibody by specific binding.Type: ApplicationFiled: September 24, 2013Publication date: February 6, 2014Applicant: OncImmune Ltd.Inventors: John F.R. Robertson, Andrea Murray, Caroline Chapman, Anthony Barnes
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Patent number: 8574848Abstract: The invention generally relates to the field of diagnostic or prognostic assays and in particular relates to assays for the detection of antibodies in a sample comprising patient bodily fluid, wherein such antibodies are used as biological markers of a disease state or disease susceptibility. The assay is based on cross-titration of both the patient bodily fluid to be tested for the antibody and an antigen used to detect the antibody by specific binding.Type: GrantFiled: September 12, 2007Date of Patent: November 5, 2013Assignee: OncImmune Ltd.Inventors: John F. R. Robertson, Andrea Murray, Caroline Chapman, Anthony Barnes
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Patent number: 8114604Abstract: A method of determining the immune response of a mammal to circulating tumour marker proteins is described in which a sample of bodily fluid, for example plasma or serum, is contacted with a panel of two or more distinct tumour marker antigen. The presence of complexes between the tumour marker antigens and any autoantibodies to the antigens present in the sample are detected and provide an indication of an immune response to a circulating tumour marker protein. The method is useful for the diagnosis of cancer, particularly for identifying new or recurrent cancer in an otherwise assymptomatic patient.Type: GrantFiled: December 10, 2007Date of Patent: February 14, 2012Assignee: OncImmune Ltd.Inventors: John F. R. Robertson, Catherine R. L. Graves, Michael R. Price, Frances Margaret Price, legal representative