Abstract: Tumour marker proteins and their preparation from fluids from one or more cancer patients, wherein said fluids are those which collect in a body cavity or space which is naturally occurring or which is the result of cancer or medical intervention for cancer. The present application also relates to preparation of tumour marker proteins from excretions taken from patients with cancer. The tumour marker proteins are useful as immunoassay reagents in the detection of cancer-associated anti-tumour marker autoantibodies.
Type:
Application
Filed:
November 19, 2013
Publication date:
March 20, 2014
Applicant:
Onclmmune Limited
Inventors:
John Forsyth Russell Robertson, Catherine Rosamund Louise Graves
Abstract: A method of determining the immune response of a mammal to circulating tumour marker proteins is described in which a sample of bodily fluid, for example plasma or serum, is contacted with a panel of two or more distinct tumour marker antigen. The presence of complexes between the tumour marker antigens and any autoantibodies to the antigens present in the sample are detected and provide an indication of an immune response to a circulating tumour marker protein. The method is useful for the diagnosis of cancer, particularly for identifying new or recurrent cancer in an otherwise assymptomatic patient.
Type:
Application
Filed:
April 3, 2012
Publication date:
April 11, 2013
Applicant:
Onclmmune Limited
Inventors:
John F.R. Robertson, Catherine R.L. Graves, Frances M. Price
Abstract: A method of determining the immune response of a mammal to circulating tumour marker proteins is described in which a sample of bodily fluid, for example plasma or serum, is contacted with a panel of two or more distinct tumour marker antigen. The presence of complexes between the tumour marker antigens and any autoantibodies to the antigens present in the sample are detected and provide an indication of an immune response to a circulating tumour marker protein. The method is useful for the diagnosis of cancer, particularly for identifying new or recurrent cancer in an otherwise assymptomatic patient.
Type:
Application
Filed:
January 12, 2012
Publication date:
May 10, 2012
Applicant:
Onclmmune Limited
Inventors:
John F.R. Robertson, Catherine R.L. Graves, Michael R. Price, Frances Margaret Price
Abstract: The present invention comprises methods and compositions for detecting cancer in an individual comprising autoantibodies to cancer-associated antigens. Specifically, the present invention comprises methods and compositions for detecting autoantibodies to cancer-associated antigen in a bodily fluid as well as use of said autoantibodies as a means to detect the presence of cancer-associated antigens.
Type:
Application
Filed:
December 14, 2010
Publication date:
April 14, 2011
Applicant:
Onclmmune Limited
Inventors:
John Forsyth Russell Robertson, Catherine Rosamund Louise Graves, Michael Rawling Price, Frances Margaret Price
Abstract: The invention generally relates to the field of immunoassays. In particular, the invention relates to use of a calibrator material to calibrate immunoassays for autoantibodies.
Type:
Application
Filed:
December 23, 2008
Publication date:
July 9, 2009
Applicant:
Onclmmune Limited
Inventors:
John F. R. Robertson, Andrea Murray, Caroline Chapman, Anthony Barnes