Patents Assigned to ONCOIMMUNE INC.
  • Methods of use of CD24 for the prevention and treatment of leukemia relapse
    Patent number: 11911441
    Abstract: The present invention relates to the use of a CD24 protein for preventing or treating relapse of a cancer in a subject. The present invention also relates to the use of a CD24 protein for reducing cancer stem cell activity.
    Type: Grant
    Filed: June 3, 2019
    Date of Patent: February 27, 2024
    Assignees: ONCOIMMUNE, INC., UNIVERSITY OF MARYLAND, BALTIMORE
    Inventors: Yang Liu, Pan Zheng, Martin Devenport
  • Methods of use of soluble CD24 for treating lupus nephritis
    Patent number: 11571461
    Abstract: The present invention relates to the use of a CD24 protein for treating Systemic Lupus Erythematosus (Lupus, SLE).
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: February 7, 2023
    Assignee: ONCOIMMUNE, INC.
    Inventors: Yang Liu, Pan Zheng, Martin Devenport
  • METHODS OF USE OF SOLUBLE CD24 FOR TREATING SYSTEMIC LUPUS ERYTHEMATOSUS
    Publication number: 20220125874
    Abstract: The present invention relates to the use of a CD24 protein for treating Systemic Lupus Erythematosus (Lupus, SLE).
    Type: Application
    Filed: March 6, 2018
    Publication date: April 28, 2022
    Applicant: ONCOIMMUNE, INC.
    Inventors: Yang LIU, Pan ZHENG, Martin DEVENPORT
  • METHODS OF USE OF CD24 FOR THE PREVENTION AND TREATMENT OF LEUKEMIA RELAPSE
    Publication number: 20210268061
    Abstract: The present invention relates to the use of a CD24 protein for preventing or treating relapse of a cancer in a subject. The present invention also relates to the use of a CD24 protein for reducing cancer stem cell activity.
    Type: Application
    Filed: June 3, 2019
    Publication date: September 2, 2021
    Applicants: ONCOIMMUNE, INC, UNIVERSITY OF MARYLAND, BALTIMORE
    Inventors: Yang Liu, Pan Zheng, Martin Devenport
  • METHODS OF USE OF CD24 FOR THE PREVENTION AND TREATMENT OF GRAFT VERSUS HOST DISEASE AND MUCOSITIS
    Publication number: 20210228680
    Abstract: The present invention relates to the use of a CD24 protein for preventing or treating Graft versus Host Disease and mucositis.
    Type: Application
    Filed: June 3, 2019
    Publication date: July 29, 2021
    Applicant: ONCOIMMUNE, INC
    Inventors: Yang Liu, Pan Zheng, Martin Devenport
  • ANTI-CD24 COMPOSITIONS AND USES THEREOF
    Publication number: 20210214458
    Abstract: Provided herein are anti-CD24 antibodies that selectively bind human CD24 expressed in cancer cells, but not human CD24 expressed in non-cancerous cells, and the use of such antibodies in cancer therapy.
    Type: Application
    Filed: May 13, 2019
    Publication date: July 15, 2021
    Applicants: ONCOIMMUNE, INC, CHILDREN'S RESEARCH INSTITUTE, CHILDREN'S NATIONAL MEDICAL CENTER
    Inventors: Yang Liu, Pan Zheng, Rhonda Flores, Hung-Yen Chou, Zhihong Xue, Peiying Ye, Martin Devenport
  • Use of CD24 for lowering low-density lipoprotein cholesterol levels
    Patent number: 11026995
    Abstract: The present invention relates to the use of a CD24 protein for lowering low-density lipoprotein cholesterol levels, treating and preventing atherosclerosis, and for reducing risk of cardiovascular disease.
    Type: Grant
    Filed: June 17, 2019
    Date of Patent: June 8, 2021
    Assignee: ONCOIMMUNE, INC.
    Inventors: Yang Liu, Pan Zheng
  • Use of CD24 Proteins for Treating Leptin-Deficient Conditions
    Publication number: 20210162006
    Abstract: This invention relates to the use of a CD24 protein for treating leptin-deficient conditions, such as lipodystrophy, by increasing the level of circulating leptin.
    Type: Application
    Filed: October 12, 2020
    Publication date: June 3, 2021
    Applicant: ONCOIMMUNE, INC.
    Inventors: Yang LIU, Pan ZHENG, Martin DEVENPORT
  • METHODS OF USE OF SOLUBLE CD24 FOR TREATING ACQUIRED IMMUNE DEFICIENCY SYNDROME (HIV/AIDS)
    Publication number: 20210046154
    Abstract: The present invention relates to a method of treating, mitigating, minimizing, or preventing HIV-1/AIDS by administering a CD24 protein to a subject in need thereof. Also provided herein is use of a CD24 protein in the manufacture of a medicament for treating HIV-1/AIDS. Further, provided is a pharmaceutical composition comprising a pharmaceutically acceptable amount of a CD24 protein.
    Type: Application
    Filed: March 5, 2019
    Publication date: February 18, 2021
    Applicants: ONCOIMMUNE, INC, UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL, INSTITUTE OF BIOPHYSICS, CHINESE ACADEMY OF SCIENCES, KUNMING INSTITUTE OF ZOOLOGY, CHINESE ACADEMY OF SCIENCES
    Inventors: Yang Liu, Pan Zhang, Lishan Su, Yong-Tang Zheng, Liguo Zhang
  • Use of CD24 proteins for treating leptin-deficient conditions
    Patent number: 10799558
    Abstract: This invention relates to the use of a CD24 protein for treating leptin-deficient conditions, such as lipodystrophy, by increasing the level of circulating leptin.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: October 13, 2020
    Assignee: ONCOIMMUNE, INC.
    Inventors: Yang Liu, Pan Zheng, Martin Devenport
  • Methods of use of soluble CD24 for therapy of rheumatoid arthritis
    Patent number: 10793617
    Abstract: Provided herein is a CD24 protein. The CD24 protein may include mature human or mouse CD24, as well as a N- or C-terminally fused portion of a mammalian immunoglobulin.
    Type: Grant
    Filed: August 16, 2018
    Date of Patent: October 6, 2020
    Assignee: ONCOIMMUNE, INC.
    Inventors: Xincheng Zheng, Wei Wu, Yang Liu, Pan Zheng
  • Chimeric and Humanized Anti-Human CTLA4 Monoclonal Antibodies and Uses Thereof
    Publication number: 20200283526
    Abstract: This invention relates to compositions of chimeric and humanized antibodies that bind to the human CTLA4 molecule and their use in cancer immunotherapy and for reduction of autoimmune side effects compared to other immunotherapeutic agents.
    Type: Application
    Filed: February 27, 2020
    Publication date: September 10, 2020
    Applicant: ONCOIMMUNE, INC.
    Inventors: Yang LIU, Pan ZHENG, Martin DEVENPORT
  • METHODS OF USE OF SOLUBLE CD24 FOR TREATING IMMUNE RELATED ADVERSE EVENTS IN CANCER THERAPIES
    Publication number: 20200197485
    Abstract: The present invention relates to a CD24 protein for treating immune-related adverse events (irAEs) associated with cancer immunotherapy. Provided herein is a method of treating, mitigating, minimizing, or preventing immunerelated adverse events (irAEs) associated with a cancer immunotherapy by administering a CD24 protein to a subject in need thereof. The irAE may be diarrhea or another gastrointestinal disorder, pure red cell aplasia, microcytic anemia, lupus, autoimmune nephritism, autoimmune hepatitis, pneumonitis, myocarditis, pericarditis, endocrinopathy, Addison's disease, hypogonadism, Sjogren's syndrome, or type I diabetes. The CCD24 protein may comprise a mature human CD24 or a variant thereof.
    Type: Application
    Filed: May 21, 2018
    Publication date: June 25, 2020
    Applicants: ONCOIMMUNE, INC., CHILDREN'S NATIONAL MEDICAL CENTER
    Inventors: Yang LIU, Pan ZHENG, Martin DEVENPORT
  • METHODS OF USE OF SOLUBLE CD24 FOR NEUROPROTECTION AND REMYELINATION
    Publication number: 20200181235
    Abstract: The present invention relates to compositions and their use in methods of protecting and maintaining oligodendrocytes, and of treating demyelinating disorders
    Type: Application
    Filed: May 15, 2018
    Publication date: June 11, 2020
    Applicants: ONCOIMMUNE, INC., CHILDREN'S NATIONAL MEDICAL CENTER
    Inventors: Yang LIU, Pan ZHENG, Martin DEVENPORT, Ning LI
  • Chimeric and humanized anti-human CTLA4 monoclonal antibodies and uses thereof
    Patent number: 10618960
    Abstract: This invention relates to compositions of chimeric and humanized antibodies that bind to the human CTLA4 molecule and their use in cancer immunotherapy and for reduction of autoimmune side effects compared to other immunotherapeutic agents.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: April 14, 2020
    Assignee: ONCOIMMUNE, INC.
    Inventors: Yang Liu, Pan Zheng, Martin Devenport
  • CD80 and CD86 Binding Protein Compositions and Uses Thereof
    Publication number: 20190263889
    Abstract: This invention relates to cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) protein compositions and their use in the mitigation of autoimmune adverse events associated with cancer immunotherapy. Specifically, the disclosure provides a CTLA-4 protein comprising a mutant extracellular domain of CTLA-4, wherein the CTLA-4 protein exhibits reduced binding to an anti-CTLA-4 antibody as compared to a wild-type extracellular domain of CTLA-4, wherein the anti-CTLA-4 antibody has anti-cancer immunotherapeutic activity.
    Type: Application
    Filed: September 19, 2017
    Publication date: August 29, 2019
    Applicants: ONCOIMMUNE, INC., CHILDREN'S RESEARCH INSTITUTE, CHILDREN'S NATIONAL MEDICAL CENTER
    Inventors: Yang LIU, Pan ZHENG, Martin DEVENPORT, Wei WU, Xuexiang DU, Mingyue LIU, Fei TANG
  • Chimeric and Humanized Anti-Human CTLA4 Monoclonal Antibodies and Uses Thereof
    Publication number: 20190127468
    Abstract: This invention relates to compositions of chimeric and humanized antibodies that bind to the human CTLA4 molecule and their use in cancer immunotherapy and for reduction of autoimmune side effects compared to other immunotherapeutic agents.
    Type: Application
    Filed: December 14, 2016
    Publication date: May 2, 2019
    Applicant: ONCOIMMUNE, INC.
    Inventors: Yang LIU, Pan ZHENG, Martin DEVENPORT
  • Use of CD24 Proteins for Treating Leptin-Deficient Conditions
    Publication number: 20190038716
    Abstract: This invention relates to the use of a CD24 protein for treating leptin-deficient conditions, such as lipodystrophy, by increasing the level of circulating leptin.
    Type: Application
    Filed: February 2, 2017
    Publication date: February 7, 2019
    Applicant: ONCOIMMUNE, INC.
    Inventors: Yang LIU, Pan ZHENG, Martin DEVENPORT
  • Uses of hypoxia-inducible factor inhibitors
    Patent number: 9877998
    Abstract: The present invention relates to treating a hematologic cancer using a Hypoxia-Inducible Factor (HIF inhibitor). The invention also relates to inducing acute myeloid leukemia remission using the HIF inhibitor. The invention further relates to inhibiting a maintenance or survival function of a cancer stem cell (CSC) using the HIF inhibitor.
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: January 30, 2018
    Assignee: ONCOIMMUNE, INC.
    Inventors: Yang Liu, Yin Wang, Yan Liu, Sami N. Malek, Pan Zheng
  • METHODS OF USE OF SOLUBLE CD24 FOR THERAPY OF RHEUMATOID ARTHRITIS
    Publication number: 20130136739
    Abstract: Provided herein is a method of treating rheumatoid arthritis using a CD24 protein. The CD24 protein may include mature human or mouse CD24, as well as a N- or C-terminally fused portion of a mammalian immunoglobulin.
    Type: Application
    Filed: April 28, 2011
    Publication date: May 30, 2013
    Applicant: ONCOIMMUNE, INC.
    Inventors: Xincheng Zheng, Wei Wu, Yang Liu, Pan Zheng