Abstract: The present invention relates to treating a hematologic cancer using a Hypoxia- Inducible Factor (HIF inhibitor). The invention also relates to inducing acute myeloid leukemia remission using the HIF inhibitor. The invention further relates to inhibiting a maintenance or survival function of a cancer stem cell (CSC) using the HIF inhibitor.
Type:
Application
Filed:
June 25, 2010
Publication date:
October 18, 2012
Applicant:
ONCOIMMUNE INC.
Inventors:
Yang Liu, Yin Wang, Yan Liu, Sami N. Malek, Pan Zheng