Abstract: A process for enhancing polyphenolics content of beverages brewed from polyphenolic containing, processed beverage substrate by pre-soaking substrate (coffee beans, for example) before roasting and then quenching the substrate after processing with the liquid in which the substrate was first “pre-soaked.” Beverages produced from the treated substrate exhibit substantially increased polyphenolics content, when compared to conventionally processed beverage substrate of the same nature and processing.
Type:
Grant
Filed:
September 15, 2014
Date of Patent:
September 25, 2018
Assignees:
ONCOLOGY SCIENCES CORPORATION, THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
Inventors:
Loretta Zapp, Thomas J. Slaga, Jifu Zhao, Mark Lange
Abstract: A process for enhancing polyphenolics content of beverages brewed from polyphenolic containing, processed beverage substrate by pre-soaking substrate (coffee beans, for example) before roasting and then quenching the substrate after processing with the liquid in which the substrate was first “pre-soaked.” Beverages produced from the treated substrate exhibit substantially increased polyphenolics content, when compared to conventionally processed beverage substrate of the same nature and processing.
Type:
Application
Filed:
January 15, 2013
Publication date:
May 23, 2013
Applicants:
AMC Cancer Research Center, Oncology Sciences Corporation
Inventors:
Oncology Sciences Corporation, AMC Cancer Research Center
Abstract: A process for enhancing polyphenolics content of beverages brewed from polyphenolic containing, processed beverage substrate by pre-soaking substrate (coffee beans, for example) before roasting and then quenching the substrate after processing with the liquid in which the substrate was first “pre-soaked.” Beverages produced from the treated substrate exhibit substantially increased polyphenolics content, when compared to conventionally processed beverage substrate of the same nature and processing.
Type:
Application
Filed:
April 20, 2004
Publication date:
January 6, 2005
Applicant:
Oncology Science Corporation
Inventors:
Loretta Zapp, Thomas Slaga, Jifu Zhao, Mark Lange
Abstract: The invention is of both a composition and method for inhibiting the proliferation of cancerous cells. The composition is, and the method is based on the use of a composition consisting (among active ingredients) substantially of 2-methoxyestradiol and/or one of a number of anaologues thereof. The present inventors have demonstrated beyond serious doubt that these compounds have a pronounced effect in inhibiting the proliferation of cancerous cells and, therefore, provide a desperately needed stepping stone for advancing toward meaningful treatment of cancer.
Type:
Application
Filed:
June 25, 2003
Publication date:
March 18, 2004
Applicant:
Oncology Sciences Corporation
Inventors:
Thomas J. Slaga, Addanki P. Kumar, William Allworth
Abstract: The use of 2-methoxyestradiol, analogues of 2-methoxyestradiol, their method of synthesis and therapeutic use, and the use of combinations of the 2 methoxyestradiol and its analogues, with and without synergistic compounds (namely eugenol), all in the prevention of initial onset cancers, treatment of existing cancers, and the recurrence of previously existing cancers.
Type:
Application
Filed:
September 17, 2002
Publication date:
April 17, 2003
Applicant:
Oncology Sciences Corporation
Inventors:
Thomas J. Slaga, Addanki P. Kumar, William Alworth
Abstract: The use of 2-methoxyestradiol in the prevention of initial onset cancers and the recurrence of previously existing cancers, through use of such compound in a manner to promoteo pro-apoptotic activities in target cells and tissues.
Abstract: The invention is of both a composition and method for inhibiting the proliferation of cancerous cells, and brain and nervous system cells in particular. The composition is, and the method is based on the use of a composition consisting (among active ingredients) substantially of 2-methoxyestradiol and/or one of a number of analogues thereof. The present inventors have demonstrated beyond serious doubt that these compounds have a pronounced effect in inhibiting the proliferation of cancerous brain and nervous system cells and, therefore, provide a desperately needed stepping stone for advancing toward meaningful treatment of brain and nervous system cancer.
Type:
Application
Filed:
February 6, 2001
Publication date:
February 6, 2003
Applicant:
Oncology Sciences Corporation
Inventors:
Thomas J. Slaga, Addanki P. Kumar, William Alworth
Abstract: A raw green coffee bean extraction method and coffee extract end product. The method produces a coffee extract end product which contains antioxidants (phenolic compounds), diterpenes (having detoxification properties), has greater bioavailability and greater ability to quench oxidative stress in comparison to existing polyphenol extracts.
Type:
Application
Filed:
April 25, 2001
Publication date:
October 31, 2002
Applicant:
Oncology Science Corporation
Inventors:
Loretta M. Zapp, Alan Andrews, Lyndon C. Johnson, Brian J. Slaga
Abstract: The invention is of both a composition and method for inhibiting the proliferation of cancerous cells. The composition is, and the method is based on the use of a composition consisting (among active ingredients) substantially of 2-methoxyestradiol and/or one of a number of anaologues thereof. The present inventors have demonstrated beyond serious doubt that these compounds have a pronounced effect in inhibiting the proliferation of cancerous cells and, therefore, provide a desperately needed stepping stone for advancing toward meaningful treatment of cancer.
Type:
Application
Filed:
February 5, 2001
Publication date:
June 6, 2002
Applicant:
Oncology Sciences Corporation
Inventors:
Thomas J. Slaga, Addanki P. Kumar, William Alworth
Abstract: The use of 2-methoxyestradiol, analogues of 2-methoxyestradiol, their method of synthesis and therapeutic use, and the use of combinations of the 2 methoxyestradiol and its analogues with synergistic compounds (namely eugenol), all in the prevention of initial onset cancers and the recurrence of previously existing cancers.
Type:
Application
Filed:
March 14, 2001
Publication date:
March 21, 2002
Applicant:
Oncology Sciences Corporation
Inventors:
Thomas J. Slaga, Addanki P. Kumar, William Alworth