Patents Assigned to OncoMEDx, Inc.
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Patent number: 8809020Abstract: This invention relates to the use of tumor-derived or associated extracellular ribonucleic acid (RNA) found circulating in blood plasma or serum fraction for the detection, monitoring, or evaluation of cancer or premalignant conditions. Specifically, this invention enables the extraction of circulating RNA from plasma or serum and utilizes nucleic acid amplification assays for the identification, detection, inference, monitoring, or evaluation of any neoplasm, benign, premalignant, or malignant, in humans or other animals, which might be associated with that RNA. Further, this invention allows the qualitative or quantitative detection of tumor-derived or associated extracellular RNA circulating in the plasma or serum of humans or animals with or without any prior knowledge of the presence of cancer or premalignant tissue.Type: GrantFiled: April 24, 2007Date of Patent: August 19, 2014Assignee: OncoMEDx, Inc.Inventor: Michael S. Kopreski
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Patent number: 8440396Abstract: This invention relates to the use of tumor-derived or associated extracellular ribonucleic acid (RNA) found circulating in the plasma or serum fraction of blood for the detection, monitoring, or evaluation of cancer or premalignant conditions. Specifically, this invention enables the extraction of circulating RNA from plasma or serum and utilizes nucleic acid amplification assays for the identification, detection, inference, monitoring, or evaluation of any neoplasm, benign, premalignant, or malignant, in humans or other animals, which might be associated with that RNA. Further, this invention allows the qualitative or quantitative detection of tumor-derived or associated extracellular RNA circulating in the plasma or serum of humans or animals with or without any prior knowledge of the presence of cancer or premalignant tissue.Type: GrantFiled: November 2, 2006Date of Patent: May 14, 2013Assignee: OncoMedx, Inc.Inventor: Michael S. Kopreski
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Patent number: 8163524Abstract: The invention provides methods for detecting tumor-associated RNA in plasma, serum, and other bodily fluids. In particular, the invention provides methods for detecting translocated gene RNA, including fusion gene RNA, in plasma or serum or other bodily fluids.Type: GrantFiled: September 18, 2007Date of Patent: April 24, 2012Assignee: OncoMedx, Inc.Inventor: Michael S. Kopreski
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Patent number: 8043835Abstract: The invention provides methods, reagents and kits for using extracellular RNA in bodily fluids including plasma and serum to detect, infer, or monitor diseases such as cancer and other neoplasia.Type: GrantFiled: May 31, 2006Date of Patent: October 25, 2011Assignee: OncoMEDx, Inc.Inventor: Michael S. Kopreski
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Patent number: 8030031Abstract: This invention relates to the use of tumor-derived or associated extracellular ribonucleic acid (RNA) found circulating in the plasma or serum fraction of blood for the detection, monitoring, or evaluation of cancer or premalignant conditions. Specifically, this invention enables the extraction of circulating RNA from plasma or serum and utilizes nucleic acid amplification assays for the identification, detection, inference, monitoring, or evaluation of any neoplasm, benign, premalignant, or malignant, in humans or other animals, which might be associated with that RNA. Further, this invention allows the qualitative or quantitative detection of tumor-derived or associated extracellular RNA circulating in the plasma or serum of humans or animals with or without any prior knowledge of the presence of cancer or premalignant tissue.Type: GrantFiled: July 23, 2004Date of Patent: October 4, 2011Assignee: OncoMedx, Inc.Inventor: Michael Kopreski
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Patent number: 7972817Abstract: This invention relates to the use of extracellular ribonucleic acid (RNA) found circulating in the plasma or serum fraction of blood. Specifically, this invention enables the extraction of circulating RNA from plasma or serum and utilizes nucleic acid amplification assays for the identification, detection, inference, monitoring, or evaluation of any such RNA. Further, this invention allows the qualitative or quantitative detection of extracellular RNA circulating in the plasma or serum of humans.Type: GrantFiled: August 31, 2005Date of Patent: July 5, 2011Assignee: OncoMedx, Inc.Inventor: Michael Kopreski
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Patent number: 7968317Abstract: This invention provides methods for detecting the presence of malignant or premalignant cells, or trophoblastic cells in a human wherein the malignant, premalignant or trophoblastic cells express 5T4. The methods of the invention detect 5T4 RNA in blood, blood plasma, serum, and other bodily fluids. The inventive methods are useful for detection, diagnosis, monitoring, treatment, or evaluation of neoplastic disease, and for the detection and evaluation of placental tissue in pregnant women.Type: GrantFiled: May 2, 2006Date of Patent: June 28, 2011Assignee: OncoMedx, Inc.Inventors: Michael S. Kopreski, Christopher D. Gocke
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Patent number: 7932061Abstract: This invention relates to the use of tumor-derived or associated extracellular ribonucleic acid (RNA) found circulating in the plasma or serum fraction of blood for the detection, monitoring, or evaluation of cancer or premalignant conditions. Specifically, this invention enables the extraction of circulating RNA from plasma or serum and utilizes nucleic acid amplification assays for the identification, detection, inference, monitoring, or evaluation of any neoplasm, benign, premalignant, or malignant, in humans or other animals, which might be associated with that RNA. Further, this invention allows the qualitative or quantitative detection of tumor-derived or associated extracellular RNA circulating in the plasma or serum of humans or animals with or without any prior knowledge of the presence of cancer or premalignant tissue.Type: GrantFiled: February 28, 2006Date of Patent: April 26, 2011Assignee: OncoMEDx, Inc.Inventor: Michael Kopreski
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Patent number: 7910336Abstract: This invention relates to methods of detecting extracellular hTR RNA and hTERT RNA in blood, plasma, serum, and other bodily fluids. The invention thereby provides an aid for the detection, diagnosis, monitoring, treatment, or evaluation of neoplastic disease.Type: GrantFiled: June 9, 2003Date of Patent: March 22, 2011Assignee: OncoMEDx, Inc.Inventors: Michael S. Kopreski, Christopher D. Gocke
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Patent number: 7785842Abstract: The invention provides methods, reagents and kits for enabling comparative analysis of extracellular RNA species in bodily fluids including plasma and serum to detect, infer, or monitor cancer and other neoplasia.Type: GrantFiled: February 2, 2006Date of Patent: August 31, 2010Assignee: OncoMEDx, Inc.Inventor: Michael S. Kopreski
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Patent number: 7767422Abstract: This invention provides methods for detecting the presence of malignant or premalignant cells, or trophoblastic cells in a human wherein the malignant, premalignant or trophoblastic cells express 5T4. The methods of the invention detect 5T4 RNA in blood, blood plasma, serum, and other bodily fluids. The inventive methods are useful for detection, diagnosis, monitoring, treatment, or evaluation of neoplastic disease, and for the detection and evaluation of placental tissue in pregnant women.Type: GrantFiled: August 21, 2001Date of Patent: August 3, 2010Assignee: Oncomedx, Inc.Inventors: Michael S. Kopreski, Christopher D. Gocke
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Patent number: 7767390Abstract: The methods of the invention detect in a qualitative or quantitative fashion drug-resistance RNA and DNA in blood plasma, serum, and other bodily fluids. The methods of the invention thereby enable the assessment of drug resistance in a neoplasm without the requirement of a tissue biopsy. The inventive methods are useful for the evaluation, monitoring, and selecting of drug treatment regimens, and for determining a predisposition for or prognosis of chemoresistant neoplastic disease.Type: GrantFiled: November 19, 2002Date of Patent: August 3, 2010Assignee: OncoMEDx, Inc.Inventor: Michael S. Kopreski
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Patent number: 7767423Abstract: This invention relates to the use of tumor-derived or associated extracellular ribonucleic acid (RNA) found circulating in the plasma or serum fraction of blood for the detection, monitoring, or evaluation of cancer or premalignant conditions. Specifically, this invention enables the extraction of circulating RNA from plasma or serum and utilizes nucleic acid amplification assays for the identification, detection, inference, monitoring, or evaluation of any neoplasm, benign, premalignant, or malignant, in humans or other animals, which might be associated with that RNA. Further, this invention allows the qualitative or quantitative detection of tumor-derived or associated extracellular RNA circulating in the plasma or serum of humans or animals with or without any prior knowledge of the presence of cancer or premalignant tissue.Type: GrantFiled: May 3, 2006Date of Patent: August 3, 2010Assignee: OncoMEDx, IncInventor: Michael Kopreski
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Publication number: 20100159464Abstract: The methods of the invention detect in a qualitative or quantitative fashion DNA methyltransferase RNA in blood plasma, serum, and other bodily fluids. The inventive methods are useful for aiding detection, diagnosis, monitoring, treatment, or evaluation of neoplastic disease, and for identifying individuals who might benefit from therapeutic approaches that target DNA methyltransferase RNA or protein.Type: ApplicationFiled: November 12, 2009Publication date: June 24, 2010Applicant: ONCOMEDX, INC.Inventor: Michael S. Kopreski
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Patent number: 7732141Abstract: The methods of the invention detect in a qualitative or quantitative fashion drug-resistance RNA and DNA in blood plasma, serum, and other bodily fluids. The methods of the invention thereby enable the assessment of drug resistance in a neoplasm without the requirement of a tissue biopsy. The inventive methods are useful for the evaluation, monitoring, and selecting of drug treatment regimens, and for determining a predisposition for or prognosis of chemoresistant neoplastic disease.Type: GrantFiled: April 24, 2007Date of Patent: June 8, 2010Assignee: OncoMEDx, Inc.Inventor: Michael S. Kopreski
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Patent number: 7709233Abstract: The methods of the invention detect epidermal growth factor RNA, epidermal growth factor receptor RNA, her-2/neu RNA, c-myc RNA, heterogeneous nuclear ribonucleoprotein A2/B1 RNA or any combination thereof in blood plasma, serum, and other bodily fluids. The inventive methods are useful for detection, diagnosis, monitoring, treatment, or evaluation of neoplastic disease.Type: GrantFiled: October 14, 2003Date of Patent: May 4, 2010Assignee: OncoMEDx, Inc.Inventor: Michael S. Kopreski
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Publication number: 20090291438Abstract: The invention provides methods and kits for enabling quantitative or qualitative analysis of extracellular RNA species in non-cellular bodily fluids including plasma and serum to detect, infer, evaluate, or monitor cancer and other neoplasia or other diseases of interest.Type: ApplicationFiled: February 20, 2007Publication date: November 26, 2009Applicant: OncoMEDx, Inc.Inventor: Michael S. Kopreski
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Publication number: 20090233276Abstract: This invention relates to the use of tumor-derived or associated extracellular ribonucleic acid (RNA) found circulating in the plasma or serum fraction of blood for the detection, monitoring, or evaluation of cancer or premalignant conditions. Extracellular RNA may circulate as non-bound RNA, protein-bound RNA, lipid-RNA complexes, lipoprotein (proteolipid)-RNA complexes, protein-RNA complexes including within or in association with ribonucleoprotein complexes, nucleosomes, or within apoptotic bodies. Any intracellular RNA found in plasma or serum can additionally be detected by this invention. Specifically, this invention enables the extraction of circulating RNA from plasma or serum and utilizes nucleic acid amplification assays for the identification, detection, inference, monitoring, or evaluation of any neoplasm, benign, premalignant, or malignant, in humans or other animals, which might be associated with that RNA.Type: ApplicationFiled: April 24, 2007Publication date: September 17, 2009Applicant: ONCOMEDX, INC.Inventor: Michael S. Kopreski
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Publication number: 20090136942Abstract: The invention provides methods for detecting tumor-associated RNA in plasma, serum, and other bodily fluids. In particular, the invention provides methods for detecting translocated gene RNA, including fusion gene RNA, in plasma or serum or other bodily fluids.Type: ApplicationFiled: September 17, 2008Publication date: May 28, 2009Applicant: OncoMEDx, Inc.Inventor: Michael S. Kopreski
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Publication number: 20080286784Abstract: The methods of the invention detect in a qualitative or quantitative fashion DNA methyltransferase RNA in blood plasma, serum, and other bodily fluids. The inventive methods are useful for aiding detection, diagnosis, monitoring, treatment, or evaluation of neoplastic disease, and for identifying individuals who have a predisposition to disease or who might benefit from further evaluation, monitoring or therapy.Type: ApplicationFiled: April 4, 2008Publication date: November 20, 2008Applicant: ONCOMEDX, INC.Inventor: Michael S. Kopreski