Patents Assigned to ONCORUS, INC.
  • Oncolytic viral delivery of therapeutic polypeptides
    Patent number: 10604574
    Abstract: Described herein are pseudotyped oncolytic viruses comprising nucleic acids encoding an engager molecule. In some embodiments, the pseudotyped oncolytic viruses comprises nucleic acids encoding an engager molecule and one or more therapeutic molecules. Pharmaceutical compositions containing the pseudotyped oncolytic virus and methods of treating cancer using the pseudotyped oncolytic viruses are further provided herein.
    Type: Grant
    Filed: October 25, 2018
    Date of Patent: March 31, 2020
    Assignee: ONCORUS, INC.
    Inventor: Luke Evnin
  • Oncolytic viral vectors and uses thereof
    Patent number: 10391132
    Abstract: The present disclosure relates to recombinant viral vectors for the treatment and prevention of cancer. Oncolytic viral vectors incorporate one or more of the following features: viral replication restriction by insertion of tumor-suppressive microRNA (miRNA) target sequences into the viral genome; disruption of oncogenic miRNA function; cancer microenvironment remodeling; and cancer cell targeting by incorporation of protease-activated antibodies into the viral particle.
    Type: Grant
    Filed: July 27, 2018
    Date of Patent: August 27, 2019
    Assignee: ONCORUS, INC.
    Inventors: Kenneth P. Greenberg, Mitchell H. Finer