Abstract: The present invention relates to the fields of life sciences and medicine. Specifically, the invention relates to cancer therapies. More specifically, the present invention relates to oncolytic adenoviral vectors and cells and pharmaceutical compositions comprising said vectors. The present invention also relates to said vectors for treating cancer in a subject and a method of treating cancer in a subject. Furthermore, the present invention relates to methods of producing CD40L in a cell and increasing tumor specific immune response and apoptosis in a subject, as well to uses of the oncolytic adenoviral vector of the invention for producing CD40L in a cell and increasing tumor specific immune response and apoptosis, while decreasing tumor-associated immunosuppression, in a subject.
Type:
Application
Filed:
September 23, 2011
Publication date:
December 5, 2013
Applicant:
ONCOS THERAPEUTICS OY
Inventors:
Iulia Diaconu, Sari Pesonen, Akseli Hemminki, Vincenzo Cerullo
Abstract: The present invention relates to the fields of life sciences and medicine. Specifically, the invention relates to cancer therapies. More specifically, the present invention relates to oncolytic adenoviral vectors and cells and pharmaceutical compositions comprising said vectors. The present invention also relates to said vectors for treating cancer in a subject and a method of treating cancer in a subject. Furthermore, the present invention relates to methods of producing monoclonal anti-CTLA4 antibodies in a cell and increasing tumor specific immune response and apoptosis in a subject, as well as uses of the oncolytic adenoviral vectors for producing monoclonal anti-CTLA4 antibodies in a cell and increasing tumor specific immune response and apoptosis in a subject.
Type:
Application
Filed:
September 23, 2011
Publication date:
September 19, 2013
Applicant:
ONCOS Therapeutics OY
Inventors:
Joao Dias, Vincenzo Cerullo, Akseli Hemminki, Sari Personen
Abstract: Oncolytic human adenoviral vectors and cells and pharmaceutical compositions including the vectors. Also provided are methods for using the vectors in the manufacture of a medicament for treating cancer in a subject and a method of treating cancer in a subject. Furthermore, methods of producing an adenoviral vector are provided.
Type:
Application
Filed:
February 2, 2010
Publication date:
March 15, 2012
Applicant:
ONCOS THERAPEUTICS OY
Inventors:
Otto Hemminki, Gerd Bauerschmitz, Vincenzo Cerullo, Sari Pesonen, Akseli Hemminki