Abstract: Provided herein are compositions that comprise negatively charged particles and methods of making and using the same. Also provided are methods of reducing or treating Cytokine Storm Syndrome (CSS) or Acute Rcspiratoiy Distress Syndrome (ARDS).
Abstract: The current invention involves the administration of negatively charged particles, such as polystyrene, PLGA, or diamond particles, to subjects to ameliorate inflammatory immune responses. Additionally, the present invention describes methods of treating inflammatory diseases by administering these same negatively charged particles.
Abstract: The presently claimed invention relates to methods of reducing the duration or severity of an inflammatory immune response. In embodiments, the method comprises administering poly (lactic acid) (PLA) particles, poly (glycolic acid) (PGA) particles, poly (lactic-co-glycolic acid) (PLGA) particles, or combinations thereof; wherein said particles are modified to contain one or more carboxyl groups on the particle's surface. In embodiments, the particles do not comprise therapeutically active ingredients.
Type:
Grant
Filed:
October 3, 2018
Date of Patent:
June 1, 2021
Assignee:
onCour Pharma, Inc.
Inventors:
Daniel R. Getts, Rachael Terry, Nicholas King