Abstract: This invention relates to a second generation, plant-produced synthetic Orbivirus candidate vaccine. The vaccine comprises a plant produced chimaeric Orbivirus virus like particle (VLP) comprising at least one structural protein from one Orbivirus serotype and at least one structural protein selected from another serotype of the Orbivirus, wherein both structural capsid proteins are from the same Orbivirus species. In particular the invention relates to a vaccine against an Orbivirus, a method of producing chimaeric Orbivirus virus-like particles (VLPs) for use in a method of prevention and/or treatment of an Orbivirus infection, the use of the chimaeric Orbivirus VLPs in the manufacture of a vaccine for an Orbivirus, and a method of preventing and/or treating an Orbivirus infection.
Type:
Application
Filed:
June 1, 2021
Publication date:
December 16, 2021
Applicants:
CSIR, UNIVERSITY OF CAPE TOWN, ONDERSTEPOORT BIOLOGICAL PRODUCTS SOC LTD
Inventors:
Albertha René VAN ZYL, Ann Elizabeth MEYERS, Daria Anna RUTKOWSKA, Edward Peter RYBICKI, Hester Catharina STARK, Martha Magaretha O'KENNEDY, Nobalanda Betty MOKOENA
Abstract: This invention relates to a second generation, plant-produced synthetic Orbivirus candidate vaccine. The vaccine comprises a plant produced chimaeric Orbivirus virus like particle (VLP) comprising at least one structural protein from one Orbivirus serotype and at least one structural protein selected from another serotype of the Orbivirus, wherein both structural capsid proteins are from the same Orbivirus species. In particular the invention relates to a vaccine against an Orbivirus, a method of producing chimaeric Orbivirus virus-like particles (VLPs) for use in a method of prevention and/or treatment of an Orbivirus infection, the use of the chimaeric Orbivirus VLPs in the manufacture of a vaccine for an Orbivirus, and a method of preventing and/or treating an Orbivirus infection.
Type:
Grant
Filed:
April 19, 2017
Date of Patent:
July 6, 2021
Assignees:
CSIR, UNIVERSITY OF CAPE TOWN, ONDERSTEPOORT BIOLOGICAL PRODUCTS SOC LTD
Inventors:
Albertha René Van Zyl, Ann Elizabeth Meyers, Daria Anna Rutkowska, Edward Peter Rybicki, Hester Catharina Stark, Martha Magaretha O'Kennedy, Nobalanda Betty Mokoena
Abstract: This invention relates to a second generation, plant-produced synthetic Orbivirus candidate vaccine. The vaccine comprises a plant produced chimaeric Orbivirus virus like particle (VLP) comprising at least one structural protein from one Orbivirus serotype and at least one structural protein selected from another serotype of the Orbivirus, wherein both structural capsid proteins are from the same Orbivirus species. In particular the invention relates to a vaccine against an Orbivirus, a method of producing chimaeric Orbivirus virus-like particles (VLPs) for use in a method of prevention and/or treatment of an Orbivirus infection, the use of the chimaeric Orbivirus VLPs in the manufacture of a vaccine for an Orbivirus, and a method of preventing and/or treating an Orbivirus infection.
Type:
Application
Filed:
April 19, 2017
Publication date:
May 9, 2019
Applicants:
CSIR, UNIVERSITY OF CAPE TOWN, ONDERSTEPOORT BIOLOGICAL PRODUCTS SOC LTD
Inventors:
Albertha René VAN ZYL, Ann Elizabeth MEYERS, Daria Anna RUTKOWSKA, Edward Peter RYBICKI, Hester Catharina STARK, Martha Magaretha O'KENNEDY, Nobalanda Betty MOKOENA