Patents Assigned to Onkologichesky Nauchy Tsentr Rossiiskoi Akademii Nauk
  • Agent for suppressing tumor growth
    Patent number: 6004953
    Abstract: The invention relates to the field of biology and medicine, in particular to suppression of the growth of malignant tumors.The object of the present invention is to find more effective and less toxic drugs for suppression of tumor growth.The essence of the proposed invention is that in order to suppress tumor growth, a drug consisting of a biogenic reductant and a complex of cobalt or iron with substituted phthalocyanines (I) or naphthalocyanines (II) is used. ##STR1## where R.dbd.COONa, SO.sub.3 Na, CH.sub.2 C.sub.5 H.sub.5 N.sup..sym. Cl.sup.-, CH.sub.2 (NH.sub.2).sub.2 S.sup..sym. CCl.sup.-.Use of the proposed drug makes it possible to suppress effectively the growth of a wide range of malignant tumors, in particular to achieve the suppression of proliferation of cancer cells (in vitro), inhibition of the growth of tumors in mice (in vivo) and a substantial increase in their life-span, including that obtained in comparison with use of the prototype.
    Type: Grant
    Filed: May 27, 1997
    Date of Patent: December 21, 1999
    Assignees: Institut Elementoorganicheskikh Soedineny Rossiiskoi Akademii Nauk, Gosudarsvenny Nauchy Tsentr Rossiiskoi Federatsii "Niopik", Onkologichesky Nauchy Tsentr Rossiiskoi Akademii Nauk, Moskovsky Naucho-Issledovatelsky Onkologichesky Institut
    Inventors: Mark Efimovich Volpin, deceased, Georgy Nikolaevich Vorozhtsov, Nadezhda Jurievna Krainova, Ilya Yakovlevich Levitin, Jury Mikhailovich Luzhkov, Evgeny Antonovich Lukiyanets, Galina Konstantinovna Gerasimova, Olga Stepanovna Zhukova, Natalya Ivanovna Kazachkina, Oleg Leonidovich Kalia, Nikolaevna Novodarova Galina, deceased, Elena Mikhailovna Treschalina, Anatoly Borisovich Syrkin, Valery Ivanovich Chissov, Raisa Ivanovna Yakubovskaya