Patents Assigned to ONKURE, INC.
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Publication number: 20260078103Abstract: Novel PI3K inhibitors of the general formula (1) are described along with methods of their preparation and their use in the treatment of diseases associated with the elevation or activation of the PI3K pathway, wherein R1 to R8 are as defined.Type: ApplicationFiled: September 6, 2023Publication date: March 19, 2026Applicant: OnKure, Inc.Inventors: James F. BLAKE, Mark Laurence BOYS, David A. MARESKA, Joshua Nathaniel PAYETTE, Christie A. SCHULTE, Bryan YESTREPSKY, Qian ZHAO
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Publication number: 20250152560Abstract: A method of treating cancer in a subject in need thereof, wherein the method comprises administration of therapeutically effective amounts of OKI-179 and binimetinib or a pharmaceutically acceptable salt thereof, or administration of therapeutically effective amounts of OKI-179, binimetinib or a pharmaceutically acceptable salt thereof, and encorafenib or a pharmaceutically acceptable salt thereof according to the dosing schedules described herein.Type: ApplicationFiled: February 13, 2023Publication date: May 15, 2025Applicants: OnKure, Inc., Array BioPharma Inc.Inventors: Anthony D. Piscopio, Patrice Anne Lee, James Winkler, Richard D. Woessner
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Patent number: 12252511Abstract: Processes for preparing compounds of Formula (1) and Formula (2) are described, wherein X, Y, Z, R1-R7, L and n are defined herein. Intermediates useful in the preparation of the compounds of Formula (1) and Formula (2) are also described.Type: GrantFiled: July 14, 2023Date of Patent: March 18, 2025Assignee: OnKure, Inc.Inventors: Anthony D. Piscopio, Xiaoyong Fu, Feng Shi, Huayan Liu, Zhifeng Li
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Publication number: 20240116989Abstract: Processes for preparing compounds of Formula (1) and Formula (2) are described, wherein X, Y, Z, R1-R7, L and n are defined herein. Intermediates useful in the preparation of the compounds of Formula (1) and Formula (2) are also described.Type: ApplicationFiled: July 14, 2023Publication date: April 11, 2024Applicant: OnKure, Inc.Inventors: Anthony D. Piscopio, Xiaoyong Fu, Feng Shi, Huayan Liu, Zhifeng Li
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Patent number: 11739123Abstract: Processes for preparing compounds of Formula (1) and Formula (2) are described, wherein X, Y, Z, R1-R7, L and n are defined herein. Intermediates useful in the preparation of the compounds of Formula (1) and Formula (2) are also described.Type: GrantFiled: June 7, 2021Date of Patent: August 29, 2023Assignee: OnKure, Inc.Inventors: Anthony D. Piscopio, Xiaoyong Fu, Feng Shi, Huayan Liu, Zhifeng Li
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Patent number: 11339150Abstract: Novel compounds of Formula I are described, where the compounds are selective HDAC6 inhibitors suitable for treatment of diseases associated with HDAC6, where X, Y, Z, A1, A2, Q1 and Q2 are as described.Type: GrantFiled: December 23, 2020Date of Patent: May 24, 2022Assignee: OnKure, Inc.Inventors: Anthony D. Piscopio, Gan Zhang, Kevin Hunt
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Publication number: 20220041584Abstract: Novel compounds of Formula I are described, where the compounds are selective HDAC6 inhibitors suitable for treatment of diseases associated with HDAC6, where X, Y, Z, A1, A2, Q1 and Q2 are as described.Type: ApplicationFiled: December 23, 2020Publication date: February 10, 2022Applicant: OnKure, Inc.Inventors: Anthony D. Piscopio, Gan Zhang, Kevin Hunt
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Publication number: 20220017538Abstract: The present invention provides a novel macrocyclic prodrug compound of general Formula (I), a pharmaceutical composition comprising a compound of Formula (I), and a method for treating diseases mediated by HDAC enzymes by administering a compound of Formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, A and Z are defined herein.Type: ApplicationFiled: June 25, 2021Publication date: January 20, 2022Applicant: OnKure, Inc.Inventor: Anthony D. Piscopio
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Publication number: 20220002347Abstract: Processes for preparing compounds of Formula (1) and Formula (2) are described, wherein X, Y, Z, R1-R7, L and n are defined herein. Intermediates useful in the preparation of the compounds of Formula (1) and Formula (2) are also described.Type: ApplicationFiled: June 7, 2021Publication date: January 6, 2022Applicant: ONKURE, INC.Inventors: Anthony D. Piscopio, Xiaoyong Fu, Feng Shi, Huayan Liu, Zhifeng Li
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Patent number: 11203602Abstract: The present invention provides a novel macrocyclic prodrug compound of general Formula (I), a pharmaceutical composition comprising a compound of Formula (I), and a method for treating diseases mediated by HDAC enzymes by administering a compound of Formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, A and Z are defined herein.Type: GrantFiled: May 18, 2017Date of Patent: December 21, 2021Assignee: OnKure, Inc.Inventor: Anthony D. Piscopio
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Patent number: 11053284Abstract: Processes for preparing compounds of Formula (1) and Formula (2) are described, wherein X, Y, Z, R1-R7, L and n are defined herein. Intermediates useful in the preparation of the compounds of Formula (1) and Formula (2) are also described.Type: GrantFiled: February 4, 2020Date of Patent: July 6, 2021Assignee: ONKURE, INC.Inventors: Anthony D. Piscopio, Xiaoyong Fu, Feng Shi, Huayan Liu, Zhifeng Li
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Publication number: 20200347097Abstract: Processes for preparing compounds of Formula (1) and Formula (2) are described, wherein X, Y, Z, R1-R7, L and n are defined herein. Intermediates useful in the preparation of the compounds of Formula (1) and Formula (2) are also described.Type: ApplicationFiled: February 4, 2020Publication date: November 5, 2020Applicant: ONKURE, INC.Inventors: Anthony D. Piscopio, Xiaoyong Fu, Feng Shi, Huayan Liu, Zhifeng Li
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Publication number: 20200317693Abstract: The present invention provides a novel macrocyclic prodrug compound of general Formula (I), a pharmaceutical composition comprising a compound of Formula (I), and a method for treating diseases mediated by HDAC enzymes by administering a compound of Formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, A and Z are defined herein.Type: ApplicationFiled: May 18, 2017Publication date: October 8, 2020Applicant: OnKure, Inc.Inventor: Anthony D. Piscopio
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Patent number: 10689419Abstract: Processes for preparing compounds of Formula (1) and Formula (2) are described, wherein X, Y, Z, R1-R7, L and n are defined herein. Intermediates useful in the preparation of the compounds of Formula (1) and Formula (2) are also described.Type: GrantFiled: September 11, 2018Date of Patent: June 23, 2020Assignee: ONKURE, INC.Inventors: Anthony D. Piscopio, Xiaoyong Fu, Feng Shi, Huayan Liu, Zhifeng Li
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Publication number: 20190177372Abstract: Processes for preparing compounds of Formula (1) and Formula (2) are described, wherein X, Y, Z, R1-R7, L and n are defined herein. Intermediates useful in the preparation of the compounds of Formula (1) and Formula (2) are also described.Type: ApplicationFiled: September 11, 2018Publication date: June 13, 2019Applicant: ONKURE, INC.Inventors: Anthony D. Piscopio, Xiaoyong Fu, Feng Shi, Huayan Liu, Zhifeng Li
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Patent number: 10100089Abstract: Processes for preparing compounds of Formula (1) and Formula (2) are described, wherein X, Y, Z, R1-R7, L and n are defined herein. Intermediates useful in the preparation of the compounds of Formula (1) and Formula (2) are also described.Type: GrantFiled: May 27, 2015Date of Patent: October 16, 2018Assignee: ONKURE, INC.Inventors: Anthony D. Piscopio, Xiaoyong Fu, Feng Shi, Huayan Liu, Zhifeng Li
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Publication number: 20170183382Abstract: Processes for preparing compounds of Formula (1) and Formula (2) are described, wherein X, Y, Z, R1-R7, L and n are defined herein. Intermediates useful in the preparation of the compounds of Formula (1) and Formula (2) are also described.Type: ApplicationFiled: May 27, 2015Publication date: June 29, 2017Applicant: ONKURE, INC.Inventors: Anthony D. Piscopio, Xiaoyong Fu, Feng Shi, Huayan Liu, Zhifeng Li
