Patents Assigned to ONKURE, INC.
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Publication number: 20240116989Abstract: Processes for preparing compounds of Formula (1) and Formula (2) are described, wherein X, Y, Z, R1-R7, L and n are defined herein. Intermediates useful in the preparation of the compounds of Formula (1) and Formula (2) are also described.Type: ApplicationFiled: July 14, 2023Publication date: April 11, 2024Applicant: OnKure, Inc.Inventors: Anthony D. Piscopio, Xiaoyong Fu, Feng Shi, Huayan Liu, Zhifeng Li
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Patent number: 11739123Abstract: Processes for preparing compounds of Formula (1) and Formula (2) are described, wherein X, Y, Z, R1-R7, L and n are defined herein. Intermediates useful in the preparation of the compounds of Formula (1) and Formula (2) are also described.Type: GrantFiled: June 7, 2021Date of Patent: August 29, 2023Assignee: OnKure, Inc.Inventors: Anthony D. Piscopio, Xiaoyong Fu, Feng Shi, Huayan Liu, Zhifeng Li
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Patent number: 11339150Abstract: Novel compounds of Formula I are described, where the compounds are selective HDAC6 inhibitors suitable for treatment of diseases associated with HDAC6, where X, Y, Z, A1, A2, Q1 and Q2 are as described.Type: GrantFiled: December 23, 2020Date of Patent: May 24, 2022Assignee: OnKure, Inc.Inventors: Anthony D. Piscopio, Gan Zhang, Kevin Hunt
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Publication number: 20220041584Abstract: Novel compounds of Formula I are described, where the compounds are selective HDAC6 inhibitors suitable for treatment of diseases associated with HDAC6, where X, Y, Z, A1, A2, Q1 and Q2 are as described.Type: ApplicationFiled: December 23, 2020Publication date: February 10, 2022Applicant: OnKure, Inc.Inventors: Anthony D. Piscopio, Gan Zhang, Kevin Hunt
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Publication number: 20220017538Abstract: The present invention provides a novel macrocyclic prodrug compound of general Formula (I), a pharmaceutical composition comprising a compound of Formula (I), and a method for treating diseases mediated by HDAC enzymes by administering a compound of Formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, A and Z are defined herein.Type: ApplicationFiled: June 25, 2021Publication date: January 20, 2022Applicant: OnKure, Inc.Inventor: Anthony D. Piscopio
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Publication number: 20220002347Abstract: Processes for preparing compounds of Formula (1) and Formula (2) are described, wherein X, Y, Z, R1-R7, L and n are defined herein. Intermediates useful in the preparation of the compounds of Formula (1) and Formula (2) are also described.Type: ApplicationFiled: June 7, 2021Publication date: January 6, 2022Applicant: ONKURE, INC.Inventors: Anthony D. Piscopio, Xiaoyong Fu, Feng Shi, Huayan Liu, Zhifeng Li
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Patent number: 11203602Abstract: The present invention provides a novel macrocyclic prodrug compound of general Formula (I), a pharmaceutical composition comprising a compound of Formula (I), and a method for treating diseases mediated by HDAC enzymes by administering a compound of Formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, A and Z are defined herein.Type: GrantFiled: May 18, 2017Date of Patent: December 21, 2021Assignee: OnKure, Inc.Inventor: Anthony D. Piscopio
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Patent number: 11053284Abstract: Processes for preparing compounds of Formula (1) and Formula (2) are described, wherein X, Y, Z, R1-R7, L and n are defined herein. Intermediates useful in the preparation of the compounds of Formula (1) and Formula (2) are also described.Type: GrantFiled: February 4, 2020Date of Patent: July 6, 2021Assignee: ONKURE, INC.Inventors: Anthony D. Piscopio, Xiaoyong Fu, Feng Shi, Huayan Liu, Zhifeng Li
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Publication number: 20200347097Abstract: Processes for preparing compounds of Formula (1) and Formula (2) are described, wherein X, Y, Z, R1-R7, L and n are defined herein. Intermediates useful in the preparation of the compounds of Formula (1) and Formula (2) are also described.Type: ApplicationFiled: February 4, 2020Publication date: November 5, 2020Applicant: ONKURE, INC.Inventors: Anthony D. Piscopio, Xiaoyong Fu, Feng Shi, Huayan Liu, Zhifeng Li
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Publication number: 20200317693Abstract: The present invention provides a novel macrocyclic prodrug compound of general Formula (I), a pharmaceutical composition comprising a compound of Formula (I), and a method for treating diseases mediated by HDAC enzymes by administering a compound of Formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, A and Z are defined herein.Type: ApplicationFiled: May 18, 2017Publication date: October 8, 2020Applicant: OnKure, Inc.Inventor: Anthony D. Piscopio
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Patent number: 10689419Abstract: Processes for preparing compounds of Formula (1) and Formula (2) are described, wherein X, Y, Z, R1-R7, L and n are defined herein. Intermediates useful in the preparation of the compounds of Formula (1) and Formula (2) are also described.Type: GrantFiled: September 11, 2018Date of Patent: June 23, 2020Assignee: ONKURE, INC.Inventors: Anthony D. Piscopio, Xiaoyong Fu, Feng Shi, Huayan Liu, Zhifeng Li
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Publication number: 20190177372Abstract: Processes for preparing compounds of Formula (1) and Formula (2) are described, wherein X, Y, Z, R1-R7, L and n are defined herein. Intermediates useful in the preparation of the compounds of Formula (1) and Formula (2) are also described.Type: ApplicationFiled: September 11, 2018Publication date: June 13, 2019Applicant: ONKURE, INC.Inventors: Anthony D. Piscopio, Xiaoyong Fu, Feng Shi, Huayan Liu, Zhifeng Li
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Patent number: 10100089Abstract: Processes for preparing compounds of Formula (1) and Formula (2) are described, wherein X, Y, Z, R1-R7, L and n are defined herein. Intermediates useful in the preparation of the compounds of Formula (1) and Formula (2) are also described.Type: GrantFiled: May 27, 2015Date of Patent: October 16, 2018Assignee: ONKURE, INC.Inventors: Anthony D. Piscopio, Xiaoyong Fu, Feng Shi, Huayan Liu, Zhifeng Li
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Publication number: 20170183382Abstract: Processes for preparing compounds of Formula (1) and Formula (2) are described, wherein X, Y, Z, R1-R7, L and n are defined herein. Intermediates useful in the preparation of the compounds of Formula (1) and Formula (2) are also described.Type: ApplicationFiled: May 27, 2015Publication date: June 29, 2017Applicant: ONKURE, INC.Inventors: Anthony D. Piscopio, Xiaoyong Fu, Feng Shi, Huayan Liu, Zhifeng Li
