Abstract: A method for identifying a target molecular profile associated with a target cell population. A set of reference molecular profiles and a set of sample molecular profiles are received. Each sample molecular profile is associated with a sample cell from a sample cell population, which includes a mixture of target cells and reference cells. Each of the sample molecular profiles is indicative of a respective target molecular profile. An average target molecular profile is calculated. A proportion value is calculated for each sample molecular profile. A respective target molecular profile is calculated for each sample molecular profile based on the respective calculated proportion value and a closest similarity to the average target molecular profile.
Type:
Application
Filed:
October 29, 2013
Publication date:
October 15, 2015
Applicant:
ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR)
Inventors:
Gerald Quon, Syed Haider, Ang Cui, Paul C. Boutros, Quaid D. Morris
Abstract: In one aspect, there is provided a compound comprising an acetylated carboxymethylcellulose (CMC-Ac) covalently linked to: at least one poly(ethylene glycol) (PEG), and at least one hydrophobic drug. In another aspect, a self-assembling nanoparticle composition comprising such compounds is provided.
Type:
Application
Filed:
November 19, 2013
Publication date:
March 20, 2014
Applicant:
ONTARIO INSTITUTE FOR CANCER RESEARCH
Inventors:
Shyh-Dar Li, Mark John Ernsting, Wei-Lun Tang
Abstract: In one aspect, there is provided a compound comprising an acetylated carboxymethylcellulose (CMC-Ac) covalently linked to: at least one poly(ethylene glycol) (PEG), and at least one hydrophobic drug. In another aspect, a self-assembling nanoparticle composition comprising such compounds is provided.
Type:
Grant
Filed:
February 1, 2012
Date of Patent:
November 26, 2013
Assignee:
Ontario Institute for Cancer Research
Inventors:
Shyh-Dar Li, Mark John Ernsting, Wei-Lun Tang