Patents Assigned to Ony, Inc.
  • Compositions and methods for isolating lung surfactant hydrophobic proteins SP-B and SP-C
    Patent number: 6458759
    Abstract: The present invention describes compositions of biologically active surfactant proteins SP-B and SP-C of high purity and high-yield methods for isolating SP-B and SP-C.
    Type: Grant
    Filed: November 5, 1999
    Date of Patent: October 1, 2002
    Assignee: Ony, Inc.
    Inventors: Edmund A. Egan, Lynn M. Hlavaty, Bruce A. Holm
  • Modification of animal lung surfactant for treating respiratory disease due to lung surfactant deficiency or dysfunction
    Patent number: 6129934
    Abstract: The present invention relates to the method of using a composition of matter that maintains the biophysical and physiological characteristics of natural surfactant, including the rapid and spontaneous adsorption of dilute suspensions to an air-liquid interface; the generation of low surface tension (<2.1 mN/m) at a surface area compression of 50% by the pulsating bubble method of Enhorning; and the restoration of greater than 75% of the lost volume of a surfactant deficient lung as determined by the method of Bermel. The material is produced by adding disaturated phospholipid to the extract of surface active material obtained by lavage of the air space of the lungs of animals. The material contains 90-96% phospholipid, 0-6% cholesterol, and 1-3% protein. Greater than 99% of the protein is lung surfactant apoproteins B & C. A sterile pharmaceutical preparation of the surface active material can be used for treating diseases caused by deficiency or dysfunction or natural lung surfactant.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 10, 2000
    Assignee: ONY, Inc.
    Inventors: Edmund A. Egan, Bruce A. Holm, William H. Ferguson
  • Compositions and methods for isolating lung surfactant hydrophobic proteins SP-B and SP-C
    Patent number: 6020307
    Abstract: The present invention describes compositions of biologically active surfactant proteins SP-B and SP-C of high purity and high-yield methods for isolating SP-B and SP-C.
    Type: Grant
    Filed: April 25, 1997
    Date of Patent: February 1, 2000
    Assignee: ONY, Inc.
    Inventors: Edmund A. Egan, Lynn M. Hiavaty, Bruce A. Holm