Abstract: The invention relates to polynucleotides, particularly chimeric polynucleotides useful for optimal production of functional immunoglobulins with human idiotypes in rodents. The invention further relates to rodents comprising such polynucleotides.
Type:
Grant
Filed:
October 24, 2016
Date of Patent:
August 20, 2019
Assignee:
OPEN MONOCLONAL TECHNOLOGY, INC.
Inventors:
Marianne Bruggemann, Roland Buelow, Michael J. Osborn, Biao Ma