Abstract: There are provided an ophthalmic composition that comprises 3-hydroxybutyric acid and/or salts thereof as active ingredients and is used to prevent desiccation of eyes and an ophthalmic composition that is used to treat tear dysfunction. By use of the ophthalmic compositions of the present invention, desiccation of the eyes can be inhibited and tear dysfunction can be treated. Therefore, by use of the compositions, discomforts caused by tear dysfunction, such as desiccation of the eyes, foreign-body sensation, feeling of discomfort on the eyes and eye strain, can be improved. Further, the ophthalmic compositions of the present invention can inhibit diseases caused by tear dysfunction, exemplified by development of dry eye and suspected dry eye which are dysfunctions related to desiccation of the eyes, particularly, development of diseases caused by tear dysfunction without injuries on the keratoconjunctive.

Abstract: There are provided an ophthalmic composition that comprises 3-hydroxybutyric acid and/or salts thereof as active ingredients and is used to prevent desiccation of eyes and an ophthalmic composition that is used to treat tear dysfunction. By use of the ophthalmic compositions of the present invention, desiccation of the eyes can be inhibited and tear dysfunction can be treated. Therefore, by use of the compositions, discomforts caused by tear dysfunction, such as desiccation of the eyes, foreign-body sensation, feeling of discomfort on the eyes and eye strain, can be improved. Further, the ophthalmic compositions of the present invention can inhibit diseases caused by tear dysfunction, exemplified by development of dry eye and suspected dry eye which are dysfunctions related to desiccation of the eyes, particularly, development of diseases caused by tear dysfunction without injuries on the keratoconjunctive.

Abstract: A one-pack preparation of irrigating solution for ocular surgery of cataract, glaucoma or intraocular lens transplantation, which is excellent in the protection of ophthalmic tissues and endothelial cells during and after the operation and has a high in vivo stability. The preparation comprises an aqueous solution containing at least one compound selected from D-3-hydroxybutyric acid and water-soluble salts thereof, at least one compound selected from water-soluble bicarbonates, phosphoric acid and water-soluble phosphates, a water-soluble calcium salt, and a water-soluble magnesium salt.

Abstract: The present invention provides a combined formulation for disinfecting, neutralizing and cleaning a soft contact lens and a method using the same easily, efficiently and safely. The formulation is a one-solution type of combined formulation for disinfecting, neutralizing and cleaning a soft contact lens, which includes a first formulation that contains an iodine-based disinfectant and a proteolytic enzyme and a second formulation that contains a reducing and a foaming agent treated with a delayed release coating, and which contains a nonionic surfactant in at least one of the first and second formulations. A stained soft contact lens can be disinfected, neutralized and cleaned easily by holding it in an aqueous solution colored yellow or brown by iodine molecules and removing it from the aqueous solution after the solution becomes almost colorless.