Abstract: Some embodiments of the present invention may relate to a device and a method of enabling the stabilization of a series of retinal angiography images to provide a coherent serial display, the method comprising: locally matching a pair of overlapping images, said locally matching includes at least providing a best offset vector for the images, wherein the best offset vector is provided based upon a matching of features from overlapping portions of the images; globally matching at least a triplet of matching pairs of images, wherein pairs of globally matching images include locally matching pairs whose best offset vector sum is substantially zero; choosing a key image; and aligning all the remaining images to the key image.

Abstract: A novel optical subsystem is connected to an analyzing computer. The optical subsystem projects a grid of parallel lines onto a patient's retina, and a video camera in the optical subsystem captures a first retinal image and transmits it to the computer, where the image is digitized for analysis. A second image of the same eye is also captured, with the grid of parallel lines oriented perpendicular to the grid of the first image. The computer stores image data for the patient for a plurality of visits. The computer analyzes the images by forming a skeletonized topographical map of the retinal area of interest. First, a novel one-dimensional line detection algorithm is used to process the images. The line detection algorithm dilates, erodes and restores, Fourier transforms, bandpass filters, thresholds, skeletonizes, line traverses and interpolates the data for each of the two images. The resulting information is normalized to compensate for the effects of the patient's ocular optics.