Patents Assigned to OPKO Biologics Ltd.
-
Patent number: 11976106Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotropin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions and pharmaceutical formulations comprising the polypeptides and polynucleotides of the disclosure and methods of using and producing same are also disclosed.Type: GrantFiled: July 11, 2017Date of Patent: May 7, 2024Assignee: OPKO BIOLOGICS LTD.Inventors: Oren Hershkovitz, Laura Moschcovich
-
Publication number: 20220241380Abstract: CTP-modified human growth hormone polypeptides and pharmaceutical formulations and pharmaceutical compositions comprising the same and methods of producing, and using the same are disclosed.Type: ApplicationFiled: December 13, 2021Publication date: August 4, 2022Applicant: OPKO BIOLOGICS LTD.Inventors: Fuad FARES, Udi Eyal FIMA
-
Publication number: 20220170005Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.Type: ApplicationFiled: July 19, 2021Publication date: June 2, 2022Applicant: OPKO BIOLOGICS LTD.Inventors: Udi Eyal FIMA, Gili HART
-
Publication number: 20220000990Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotropin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions and pharmaceutical formulations comprising the polypeptides and polynucleotides of the disclosure and methods of using and producing same are also disclosed.Type: ApplicationFiled: March 2, 2021Publication date: January 6, 2022Applicant: OPKO BIOLOGICS LTD.Inventors: Udi Eyal FIMA, Gili Hart
-
Patent number: 11197915Abstract: CTP-modified human growth hormone polypeptides and pharmaceutical formulations and pharmaceutical compositions comprising the same and methods of producing, and using the same are disclosed.Type: GrantFiled: July 1, 2016Date of Patent: December 14, 2021Assignee: OPKO BIOLOGICS LTD.Inventors: Fuad Fares, Udi Eyal Fima
-
Publication number: 20210371487Abstract: Disclosed herein is a method for manufacturing a recombinant polypeptide of interest modified by a CTP extension in a mammalian cells culture system.Type: ApplicationFiled: February 1, 2021Publication date: December 2, 2021Applicant: OPKO BIOLOGICS LTD.Inventors: Oren HERSHKOVITZ, Laura MOSCHCOVICH
-
Patent number: 11066658Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.Type: GrantFiled: May 1, 2020Date of Patent: July 20, 2021Assignee: OPKO BIOLOGICS LTD.Inventors: Udi Eyal Fima, Gili Hart
-
Patent number: 10960058Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotropin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions and pharmaceutical formulations comprising the polypeptides and polynucleotides of the disclosure and methods of using and producing same are also disclosed.Type: GrantFiled: June 19, 2016Date of Patent: March 30, 2021Assignee: OPKO BIOLOGICS LTD.Inventors: Udi Eyal Fima, Gili Hart
-
Publication number: 20210008172Abstract: Compositions which include polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotropin attached to the carboxy terminus or amino terminus of an insulin-like growth factor 1 (IGF-1) or IGF-1 variant. Polynucleotides encoding the same are disclosed. Pharmaceutical compositions and pharmaceutical formulations comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.Type: ApplicationFiled: July 9, 2020Publication date: January 14, 2021Applicant: OPKO Biologics Ltd.Inventors: OREN HERSHKOVITZ, Lital Israeli-Yagev, Ahuva Bar-Ilan, Laura Moschcovich, Moran Golan
-
Publication number: 20200354430Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotropin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions and pharmaceutical formulations comprising the polypeptides and polynucleotides of the disclosure and methods of using and producing same are also disclosed.Type: ApplicationFiled: July 11, 2017Publication date: November 12, 2020Applicant: OPKO BIOLOGICS LTD.Inventors: Oren HERSHKOVITZ, Laura MOSCHCOVICH
-
Publication number: 20200254065Abstract: Compositions which include glucagon-like peptide-2 (GLP-2) analogs, GLP-2 analogs with reversible or non-reversible linkers attached to one or more amino acid positions of the GLP-2 analog, and GLP-2 analogs linked to one or more polyethylene glycol polymers (PEG) via reversible or non-reversible linkers are disclosed. Also disclosed are pharmaceutical compositions comprising: the GLP-2 analogs; GLP-2 analogs linked solely to reversible or non-reversible linkers; the reverse PEGylated GLP-2 analogs; and the non-reversibly PEGylated GLP-2 analogs, as well as methods of using the same.Type: ApplicationFiled: February 11, 2020Publication date: August 13, 2020Applicant: OPKO Biologics Ltd.Inventors: Oren Hershkovitz, Ahuva Bar-Ilan, Vered Lev
-
Publication number: 20200255816Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.Type: ApplicationFiled: May 1, 2020Publication date: August 13, 2020Applicant: OPKO Biologics Ltd.Inventors: UDI EYAL FIMA, GILI HART
-
Patent number: 10640758Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.Type: GrantFiled: October 15, 2018Date of Patent: May 5, 2020Assignee: OPKO Biologics Ltd.Inventors: Udi Eyal Fima, Gili Hart
-
Publication number: 20200131242Abstract: Use of a growth hormone protein and polynucleotides encoding same comprising an amino-terminal carboxy-terminal peptide (CTP) of chorionic gonadotrophin and two carboxy-terminal chorionic gonadotrophin CTPs attached to the growth hormone in methods of inducing weight loss or body fat reduction, methods of increasing insulin-like growth factor (IGF-1) levels, and methods of reducing the dosing frequency of a growth hormone in a human subject are disclosed. Pharmaceutical compositions comprising the growth hormone and polynucleotides encoding the growth hormone of the invention and methods of using same are also disclosed.Type: ApplicationFiled: July 15, 2019Publication date: April 30, 2020Applicant: OPKO BIOLOGICS LTD.Inventors: Fuad FARES, Udi Eyal FIMA
-
Patent number: 10537646Abstract: A composition which includes oxyntomodulin and polyethylene glycol polymer (PEG polymer) linked via a reversible linker such as 9-fluorenylmethoxycarbonyl (Fmoc) or 2-sulfo-9-fluorenylmethoxycarbonyl (FMS) is disclosed. Pharmaceutical compositions comprising the reverse pegylated oxyntomodulin and methods of using same are also disclosed.Type: GrantFiled: June 4, 2013Date of Patent: January 21, 2020Assignee: OPKO Biologics Ltd.Inventors: Udi Eyal Fima, Oren Hershkovitz
-
Patent number: 10538755Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotropin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.Type: GrantFiled: April 11, 2017Date of Patent: January 21, 2020Assignee: OPKO Biologics Ltd.Inventors: Udi Eyal Fima, Gili Hart
-
Patent number: 10351615Abstract: Use of a growth hormone protein and polynucleotides encoding same comprising an amino-terminal carboxy-terminal peptide (CTP) of chorionic gonadotrophin and two carboxy-terminal chorionic gonadotrophin CTPs attached to the growth hormone in methods of inducing weight loss or body fat reduction, methods of increasing insulin-like growth factor (IGF-1) levels, and methods of reducing the dosing frequency of a growth hormone in a human subject are disclosed. Pharmaceutical compositions comprising the growth hormone and polynucleotides encoding the growth hormone of the invention and methods of using same are also disclosed.Type: GrantFiled: August 2, 2012Date of Patent: July 16, 2019Assignee: OPKO Biologics Ltd.Inventors: Fuad Fares, Udi Eyal Fima
-
Publication number: 20190160152Abstract: Pharmaceutical formulations and pharmaceutical compositions comprising reverse PEGylated oxyntomodulin conjugates, and methods of producing, and using the same are described. Conjugates include those attaching a polyethylene glycol polymer (PEG polymer) and 9-fluorenylmethoxycarbonyl (Fmoc) or 2-sulfo-9-fluorenylmethoxycarbonyl (FMS) to a oxyntomodulin peptide, wherein the PEG polymer is attached to the amino terminus or to an amino residue within the oxyntomodulin via a flexible linker, wherein the flexible linker comprises a Fmoc or a FMS.Type: ApplicationFiled: June 8, 2017Publication date: May 30, 2019Applicant: OPKO BIOLOGICS LTD.Inventors: Oren HERSHKOVITZ, Ahuva BAR-ILAN, Vered LEV, Yaron TZUR
-
Patent number: 10221228Abstract: A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical compositions comprising the non-human polypeptides and polynucleotides of the invention and methods of using both human and non-human polypeptides and polynucleotides are also disclosed.Type: GrantFiled: November 26, 2014Date of Patent: March 5, 2019Assignee: OPKO Biologics Ltd.Inventors: Fuad Fares, Udi Eyal Fima
-
Publication number: 20190032038Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.Type: ApplicationFiled: October 15, 2018Publication date: January 31, 2019Applicant: OPKO Biologics Ltd.Inventors: Udi Eyal FIMA, Hart Gili