Abstract: A stable, controlled release formulation for oral dosing of vitamin D compounds is disclosed. The formulation is prepared by incorporating one or more vitamin D compounds into a solid or semi-solid mixture of waxy materials. Oral dosage forms can be prepared by melt-blending the components described herein and filling gelatin capsules with the formulation.
Type:
Grant
Filed:
November 21, 2016
Date of Patent:
March 27, 2018
Assignees:
OPKO RENAL, LLC, OPKO IRELAND GLOBAL HOLDINGS, LIMITED
Inventors:
Charles W. Bishop, Samir P. Tabash, Sammy A. Agudoawu, Jay A. White, Eric J. Messner, P. Martin Petkovich, Keith H. Crawford