Patents Assigned to Opko Ophthalmics, LLC
  • COMPOSITIONS AND METHODS FOR INHIBITION OF VEGF
    Publication number: 20130039971
    Abstract: Disclosed herein are siRNA compositions and methods useful for inhibiting expression of vascular endothelial growth factor (VEGF) isoforms. Diseases which involve angiogenesis stimulated by overexpression of VEGF, such as diabetic retinopathy, age related macular degeneration and many types of cancer, can be treated by administering small interfering RNAs as disclosed.
    Type: Application
    Filed: July 23, 2012
    Publication date: February 14, 2013
    Applicant: OPKO OPHTHALMICS, LLC
    Inventor: Nadine Dejneka
  • Compositions and methods for inhibition of VEGF
    Patent number: 8227444
    Abstract: Disclosed herein are siRNA compositions and methods useful for inhibiting expression of vascular endothelial growth factor (VEGF) isoforms. Diseases which involve angiogenesis stimulated by overexpression of VEGF, such as diabetic retinopathy, age related macular degeneration and many types of cancer, can be treated by administering small interfering RNAs as disclosed.
    Type: Grant
    Filed: December 6, 2010
    Date of Patent: July 24, 2012
    Assignee: Opko Ophthalmics, LLC
    Inventor: Nadine Dejneka
  • SIRNA AND METHODS OF MANUFACTURE
    Publication number: 20110143400
    Abstract: Double-stranded RNA of about 19 to about 25 nucleotides in length capable of regulating gene expression by RNA interference is provided. Such double-stranded RNA are particularly useful for treating disease or conditions associated with a target mRNA or gene. Methods of manufacture and methods of use of the double-stranded RNA are also provided.
    Type: Application
    Filed: December 15, 2010
    Publication date: June 16, 2011
    Applicant: OPKO OPHTHALMICS, LLC
    Inventors: Samuel Jotham Reich, N. Nicole Endejann
  • COMPOSITIONS AND METHODS FOR INHIBITION OF VEGF
    Publication number: 20110142915
    Abstract: Disclosed herein are siRNA compositions and methods useful for inhibiting expression of vascular endothelial growth factor (VEGF) isoforms. Diseases which involve angiogenesis stimulated by overexpression of VEGF, such as diabetic retinopathy, age related macular degeneration and many types of cancer, can be treated by administering small interfering RNAs as disclosed.
    Type: Application
    Filed: December 6, 2010
    Publication date: June 16, 2011
    Applicant: OPKO OPHTHALMICS, LLC
    Inventor: Nadine Dejneka
  • siRNA and methods of manufacture
    Patent number: 7872118
    Abstract: Double-stranded RNA of about 19 to about 25 nucleotides in length capable of regulating gene expression by RNA interference is provided. Such double-stranded RNA are particularly useful for treating disease or conditions associated with a target mRNA or gene. Methods of manufacture and methods of use of the double-stranded RNA are also provided.
    Type: Grant
    Filed: September 6, 2007
    Date of Patent: January 18, 2011
    Assignee: Opko Ophthalmics, LLC
    Inventors: Samuel Jotham Reich, N. Nicole Endejann
  • COMPOSITIONS AND METHODS FOR SELECTIVE INHIBITION OF VEGF
    Publication number: 20100151007
    Abstract: Disclosed herein are siRNA compositions and methods useful for inhibiting expression of vascular endothelial growth factor (VEGF) isoforms. Such compositions and methods further involve siRNA capable of selectively targeting angiogenic VEGF isoforms while selectively sparing anti-angiogenic isoforms. Diseases which involve angiogenesis stimulated by overexpression of VEGF, such as diabetic retinopathy, age related macular degeneration and many types of cancer, can be treated by administering small interfering RNAs as disclosed.
    Type: Application
    Filed: December 4, 2009
    Publication date: June 17, 2010
    Applicant: OPKO OPHTHALMICS, LLC
    Inventors: Phillip Frost, Nadine Dejneka, Ottrina S. Bond, Naveed Shams