Abstract: A method for providing a lung disease risk measure in a Computer Aided Diagnosis system is described. The method comprising the steps of: receiving a plurality of inputs for a subject, each input comprising at least one image showing all or part of the lungs of a patient and a time stamp for the image, where the inputs are obtained at varying intervals; analysing the inputs to assess temporal changes in the images using at least one of an input data encoder and a time stamp encoder; inputting the output of at least one of the encoders to a score calculator to calculate a risk score; outputting the risk score indicating the lung disease risk for the subject. A Computer Aided diagnosis system for implementing the method is also described.

Abstract: A Computer Aided Diagnosis, CADx, system (200) is described that comprises: at least one input (210, 212, 214) configured to provide at least one input medical image; and a CADx processing engine (220) configured to receive and process the at least one input medical image and produce at least one CADx score. A CADx score mapping circuit is operably coupled to the CADx processing engine (220) and configured to: map the at least one CADx score to a risk adjusted virtual score; and generate an output (235) of at least the risk adjusted virtual score associated with the processed at least one input medical image. The at least one CADx score and the risk adjusted virtual score correspond to an equivalent risk of condition or disease associated with a patient.

Abstract: A quantification system (700) is described that includes: at least one input (710) configured to provide two input medical images and two locations of interest in said input medical images that correspond to a same anatomical region; and a mapping circuit (725) configured to compute a direct quantification of change of said input medical images from the at least one input (710).

Abstract: A quantification system (300) is described that includes: at least one input (310) configured to provide at least one input medical image and provide a location of interest in the at least one input medical image; and a mapping circuit (325). The mapping circuit (325) is configured to: compute a direct quantification result from the location of interest of the at least one input medical image to a quantification of interest and output a direct first quantification result therefrom; generate a saliency map as part of the computation of the direct quantification result; and derive a segmentation from the saliency map, such that the segmentation independently generates a second quantification result that is within a result range of the direct first quantification result.