Abstract: Presented are coated nanoparticles that have a desired in vitro or in vivo effect, compositions of the coated nanoparticles, methods of use of the coated nanoparticles to achieve therapeutic or prophylactic effects in cells, organs, or subjects, and processes for forming an inverse nanoparticle encapsulating a nucleic acid, such as RNA, stabilized by an amphiphilic copolymer and coating the inverse nanoparticle with additional agents to make a water-dispersible coated nanoparticle.
Type:
Application
Filed:
December 23, 2022
Publication date:
February 20, 2025
Applicant:
OPTIMEOS LIFE SCIENCES, INC.
Inventors:
Robert F. PAGELS, Chester E. MARKWALTER, Mark ESPOSITO