Abstract: A water supply system comprising a supply line and a network of consumers, one of which being a monitored consumer who receives the least amount of pressure, a pressure regulation system comprising a pressure reducing valve (PRV) associated with a pilot valve preset to a nominal output pressure and a pressure control system comprising a differential control valve (DCV). A pickup unit is provided for measuring a flow parameter indicative of the pressure at the monitored consumer and emitting a pressure signal to a controller generating in turn a control signal responsive to the pressure signal to activate an actuator of the DCV thereby governing the flow rate through the DCV, so as to obtain desired pressure at the monitored consumer, regardless of altering flow rate through the PRV.