Abstract: Optical Coherence Tomography Angiography (OCTA) image representation is obtained having OCTA pixels assigned respective OCTA values. A vessel density map is computed from the OCTA image representation. A fractional deviation map and/or a pattern deviation map is computed for the patient from the vessel density map and a normative database, wherein: (1) the fractional deviation map represents a percent loss of vessel density at each pixel location relative to an expected value based on the normative database; and (2) computing the pattern deviation map includes: computing a pattern map of the vessel density representing a normalized vessel density pattern of the vessel density map relative to an average value of the vessel density map; and computing the pattern deviation map using the pattern map. A loss is determined by using at least one of the fractional deviation map and the pattern deviation map. Other features are also provided.

Abstract: A method of processing a 3D OCT dataset is present. A method according to some embodiments of the present invention includes obtaining an OCT data from the 3D OCT dataset; obtaining an OCTA data from the 3D OCT dataset; performing segmentation for at least one boundary on the OCT data; processing the OCTA data in a region of interest to create at least one image representation by assigning a value to each pixel of each of the image representation; and displaying at least one image representation.

Abstract: In some embodiments of the present invention, a method of reducing artifacts includes obtaining OCT/OCTA data from an OCT/OCTA imager; preprocessing OCTA/OCT volume data; extracting features from the preprocessed OCTA/OCT volume data; classifying the OCTA/OCT volume data to provide a probability determination data; determining a percentage data from the probability data determination; and reducing artifacts in response to the percentage data.

Abstract: An imager that can provide separated images corresponding to differing depths in a sample is presented. In accordance with some embodiments of the invention, an imager can include a light source; a sample arm that receives light from the light source, directs the light to a sample, and captures light returning from the sample; a modulation source that provides different modulations corresponding to differing imaging depths in the sample; a detector system to receive the captured light from the sample with the different modulations; and a processor that receives signals from the detector system and separates a plurality of images corresponding with the differing image depths in the sample.

Abstract: Embodiments of automatically aligning imager are presented. In accordance with some embodiments, an imaging system includes an adjustment stage; an auto-alignment optics mounted on the adjustment stage and coupled to image an object, the auto-alignment optics including at least one video camera providing an image of the object; imaging scanning optics mounted on the adjustment stage and coupled to scan the object; an imager coupled to the imaging scanning optics; and a processor coupled to the adjustment stage and the auto-alignment optics, the processor executing instructions to receive the image of the object and adjust the adjustment stage to align the optics with the imaging scanning optics.

Abstract: An optical coherence tomography system is provided. The system includes an OCT imager; a two-dimensional transverse scanner coupled to the OCT imager, the two-dimensional transverse scanner receiving light from the light source and coupling reflected light from a sample into the OCT imager; a computer coupled to receive 3D OCT data from the OCT imager, the computer further processes the 3D OCT data; wherein the processing the 3D OCT data includes: correcting motion artifacts in baseline mode; generating reference data in baseline mode; performing segmentation to identify volumes of interest; extracting feature information, the feature information including reflectivity, texture, or the combination thereof.

Abstract: An imaging method according to some embodiments of the present invention includes obtaining working distance information from an optical coherence tomography system, the working distance being the working distance to the sample; obtaining information from one or more ocular systems; combining the information from said optical coherence tomography information and said ocular system; and displaying said combined information.

Abstract: A method of measurement is presented. A method of measurement according to some embodiments of the present invention includes obtaining a first measurement from a first imaging method; obtaining a second measurement from a second imaging method; combining the first and the second measurement to obtain a structural information and an image representation of a structure of an eye; calculating at least one shape parameter from the structural information; and displaying the image representation of the structure of the eye.

Abstract: An imaging method is disclosed. An imaging method according to some embodiments can include obtaining a plurality of measurements of an eye for at least one location by scanning optical radiation across the eye; determining a preferred measurement axis from the plurality of measurements; and processing the plurality of measurements to obtain information of the eye.

Abstract: An imaging device to obtain images, comprising: an optical source; an x-y scanner receiving light from the optical source and directing it onto a sample; a detector receiving reflected light from the scanner; and a computer receiving a signal from the detector and providing a 3D data set containing voxels with a given voxel resolution of a sample, the computer further executing instructions for finding values other than a single axes sum to represent a set of voxels; composing a 2D image using the values.

Abstract: In accordance with some embodiments, a method of eye examination includes acquiring OCT data with a scan pattern centered on an eye cornea that includes n radial scans repeated r times, c circular scans repeated r times, and n* raster scans where the scan pattern is repeated m times, where each scan includes a A-scans, and where n is an integer that is 0 or greater, r is an integer that is 1 or greater, c is an integer that is 0 or greater, n* is an integer that is 0 or greater, m is an integer that is 1 or greater, and a is an integer greater than 1, the values of n, r, c, n*, and m being chosen to provide OCT data for a target measurement, and processing the OCT data to obtain the target measurement.

Abstract: An imager that can provide separated images corresponding to differing depths in a sample is presented. In accordance with some embodiments of the invention, an imager can include a light source; a sample arm that receives light from the light source, directs the light to a sample, and captures light returning from the sample; a modulation source that provides different modulations corresponding to differing imaging depths in the sample; a detector system to receive the captured light from the sample with the different modulations; and a processor that receives signals from the detector system and separates a plurality of images corresponding with the differing image depths in the sample.

Abstract: System and method for 3D retinal disruption/elevation detection, measurement and presentation using Optical Coherence Tomography (OCT) are provided. The present invention is capable of detecting and measuring the abnormal changes of retinal layers (retinal disruptions), caused by retinal diseases, such as hard drusen, soft drusen, Pigment Epithelium Detachment (PED), Choroidal Neovascularization (CNV), Geographic Atrophy (GA), intra retinal fluid space, and exudates etc. The presentations of the results are provided with quantitative measurements of disruptions in retina and can be used for diagnosis and treatment of retinal diseases.

Abstract: An imager that can provide separated images corresponding to differing depths in a sample is presented. In accordance with some embodiments of the invention, an imager can include a light source; a sample arm that receives light from the light source, directs the light to a sample, and captures light returning from the sample; a modulation source that provides different modulations corresponding to differing imaging depths in the sample; a detector system to receive the captured light from the sample with the different modulations; and a processor that receives signals from the detector system and separates a plurality of images corresponding with the differing image depths in the sample.

Abstract: An imaging method is disclosed. An imaging method according to some embodiments can include obtaining a plurality of measurements of an eye for at least one location by scanning optical radiation across the eye; determining a preferred measurement axis from the plurality of measurements; and processing the plurality of measurements to obtain information of the eye.

Abstract: An ophthalmic imaging apparatus is provided. The apparatus includes a fundus illumination system, the fundus illumination system includes a spatially interlaced light source array of one or more wavelength bands and a focus index illumination light source where the focus index illumination light source is mounted on a non-moving part of the ophthalmic imaging apparatus, a focus index optical assembly, and a fundus imaging system.

Abstract: An optical coherence tomography system is provided. The system includes an OCT imager; a two-dimensional transverse scanner coupled to the OCT imager, the two-dimensional transverse scanner receiving light from the light source and coupling reflected light from a sample into the OCT imager; a computer coupled to receive 3D OCT data from the OCT imager, the computer further processes the 3D OCT data; wherein the processing the 3D OCT data includes: correcting motion artifacts in baseline mode; generating reference data in baseline mode; performing segmentation to identify volumes of interest; extracting feature information, the feature information including reflectivity, texture, or the combination thereof.

Abstract: An optical coherence tomography system is provided. The system includes an OCT imager; a two-dimensional transverse scanner coupled to the OCT imager, the two-dimensional transverse scanner receiving light from the light source and coupling reflected light from a sample into the OCT imager; optics that couple light between the two-dimensional transverse scanner and the sample; a video camera coupled to the optics and acquiring images of the sample; and a computer coupled to receive images of the sample from the video camera, the computer processing the images and providing a motion offset signal based on the images to the two-dimensional transverse scanner.

Abstract: A system and methods of computer-aided diagnosis for ophthalmology are described that includes acquiring OCT data, determining an RPE fit from the OCT data, and displaying en face images based on the RPE fit.

Abstract: A method is disclosed for use in eye registrations and examinations, some embodiments of the method including acquiring scan pattern scans; forming images from the scans; registering the images; generating a feature map from the scan pattern scans; identifying features on the feature map; and recording positional information of features.