Patents Assigned to Oraya Therapeutics, Inc.
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Patent number: 9272161Abstract: Radiosurgery systems are described that are configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, and in some embodiments, other disorders or tissues of a body are treated with the dose of radiation. In some embodiments, target tissues are placed in a global coordinate system based on ocular imaging. In some embodiments, a fiducial marker is used to identify the location of the target tissues.Type: GrantFiled: July 21, 2014Date of Patent: March 1, 2016Assignee: Oraya Therapeutics, Inc.Inventors: Michael Gertner, Steven D. Hansen
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Patent number: 9025727Abstract: A method, code and system for planning the treatment a lesion on or adjacent to the retina of an eye of a patient are disclosed. There is first established at least two beam paths along which x-radiation is to be directed at the retinal lesion. Based on the known spectral and intensity characteristics of the beam, a total treatment time for irradiation along each beam paths is determined. From the coordinates of the optic nerve in the aligned eye position, there is determined the extent and duration of eye movement away from the aligned patient-eye position in a direction that moves the patient's optic nerve toward the irradiation beam that will be allowed during treatment, while still maintaining the radiation dose at the patient optic nerve below a predetermined dose level.Type: GrantFiled: July 23, 2013Date of Patent: May 5, 2015Assignee: Oraya Therapeutics, Inc.Inventors: Michael Gertner, Mark Arnoldussen, Erik Chell, Steven D. Hansen, Junzhong Liang
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Patent number: 8995618Abstract: A portable orthovoltage radiotherapy system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, the ocular structures are placed in a global coordinate system based on ocular imaging. In some embodiments, the ocular structures inside the global coordinate system lead to direction of an automated positioning system that is directed based on the ocular structures within the coordinate system.Type: GrantFiled: December 17, 2013Date of Patent: March 31, 2015Assignee: Oraya Therapeutics, Inc.Inventor: Michael Gertner
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Patent number: 8920406Abstract: An eye contact device and assembly for stabilizing a human eye at a selected position in an external coordinate system is disclosed. The device includes an eye-contact member having an inner contact surface for contacting a front surface of an eye, and a vacuum port formed within the eye-contact member by which a negative pressure can be applied between the eye and the contact surface, to stabilize the position of the eye with respect to the device. The device, which is adapted to be biased against the patient's eye, to secure the device to the eye, may be pivotally coupled to a positioning arm, and may carry one or more beam-directing elements by which the position of the device in an external coordinate system can be determined.Type: GrantFiled: February 6, 2008Date of Patent: December 30, 2014Assignee: Oraya Therapeutics, Inc.Inventors: Michael Gertner, Mark Arnoldussen, Matt Herron
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Patent number: 8923479Abstract: Embodiments provide method and systems for determining or measuring objective eye alignment in an external-coordinate system so as to define a reference axis. Additional embodiments provide a method and system of aligning an objectively determined reference axis of the eye in a selected relationship to a therapeutic axis of an ophthalmic therapeutic apparatus and/or a diagnostic axis of an ophthalmic diagnostic apparatus. Embodiments provide a method and system for planning an ophthalmic treatment procedure based on objective eye alignment in an external-coordinate system so as to define a reference axis of an eye to be treated. The reference axis may be used to position a therapeutic energy component, for example, an orthovoltage X-ray treatment device, e.g., positioned to provide treatment to tissue on the retina, such as the macula.Type: GrantFiled: January 13, 2014Date of Patent: December 30, 2014Assignee: Oraya Therapeutics, Inc.Inventors: Michael Gertner, Mark Arnoldussen, Matt Herron, Junzhong Liang
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Patent number: 8855267Abstract: A radiosurgery system is described that delivers a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, ocular structures are placed in a global coordinate system, based on ocular imaging, which leads to direction of an automated positioning system. In some embodiments, the position of an ocular structure is tracked and related to a radiosurgery system. In some embodiments, a treatment plan is utilized for a specific disease to be treated and/or structures to be avoided. In some embodiments, a fiducial aids in positioning the system. In some embodiments, a reflection off the eye is used to aid in positioning. In some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments.Type: GrantFiled: May 13, 2013Date of Patent: October 7, 2014Assignee: Oraya Therapeutics, Inc.Inventors: Michael Gertner, Steven D. Hansen, Erik Chell, Matt Herron
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Patent number: 8848869Abstract: Embodiments provide method and systems for determining alignment of a patient's body part, such as an eye, in an external coordinate system of a treatment or diagnostic device, such as a radiotherapy device, so as to define a reference axis for guiding device operation. Additional embodiments provide image-based methods and systems for aligning, tracking and monitoring motion of a body part and a treatment target in relation to a radiation beam axis. Particular ophthalmic embodiments provide method and systems including an eye-contact guide device and imaging system for aligning and tracking motion of an eye and ocular treatment target in relation to an orthovoltage X-ray beam axis, so as to monitor application of radiation to a lesion, such as a macular lesion of the retina.Type: GrantFiled: August 2, 2013Date of Patent: September 30, 2014Assignee: Oraya Therapeutics, Inc.Inventors: Michael Gertner, Mark Arnoldussen, Erik Chell, Steven D. Hansen, Matt Herron, Igor Koruga, Junzhong Liang
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Patent number: 8837675Abstract: A radiosurgery system is described that delivers a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, ocular structures are placed in a global coordinate system, based on ocular imaging, which leads to direction of an automated positioning system. In some embodiments, the position of an ocular structure is tracked and related to a radiosurgery system. In some embodiments, a treatment plan is utilized for a specific disease to be treated and/or structures to be avoided. In some embodiments, a fiducial aids in positioning the system. In some embodiments, a reflection off the eye is used to aid in positioning. In some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments.Type: GrantFiled: December 5, 2011Date of Patent: September 16, 2014Assignee: Oraya Therapeutics, Inc.Inventors: Michael Gertner, Erik Chell, Steven D. Hansen, Mark Arnoldussen, Matt Herron, Kuang-Hung Pan
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Patent number: 8787524Abstract: Radiosurgery systems are described that are configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, and in some embodiments, other disorders or tissues of a body are treated with the dose of radiation. In some embodiments, target tissues are placed in a global coordinate system based on ocular imaging. In some embodiments, a fiducial marker is used to identify the location of the target tissues.Type: GrantFiled: November 6, 2012Date of Patent: July 22, 2014Assignee: Oraya Therapeutics, Inc.Inventors: Michael Gertner, Steven D. Hansen
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Patent number: 8761336Abstract: Methods described herein include selecting a target disease having an associated therapeutic dose of radiation, determining a maximal energy in an x-ray radiation beam to be emitted from a radiotherapy system to deliver a therapeutic dose of radiation associated with the target disease to target tissue in a patient, the selected disease of the plurality of diseases requiring differing maximal energies of the x-ray radiation beam to achieve the associated therapeutic dose of radiation than the maximal energy required to achieve the associated therapeutic dose of radiation for another disease, and outputting to an output module an indication of the determined maximal energy. Methods carried out in a system that can include a processing module that receives an input including a selection of a target disease, and an output module, coupled to the processing module, that outputs, an indication of the determined maximal energy.Type: GrantFiled: January 6, 2012Date of Patent: June 24, 2014Assignee: Oraya Therapeutics, Inc.Inventor: Michael Gertner
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Publication number: 20140126700Abstract: Embodiments provide method and systems for determining or measuring objective eye alignment in an external-coordinate system so as to define a reference axis. Additional embodiments provide a method and system of aligning an objectively determined reference axis of the eye in a selected relationship to a therapeutic axis of an ophthalmic therapeutic apparatus and/or a diagnostic axis of an ophthalmic diagnostic apparatus. Embodiments provide a method and system for planning an ophthalmic treatment procedure based on objective eye alignment in an external-coordinate system so as to define a reference axis of an eye to be treated. The reference axis may be used to position a therapeutic energy component, for example, an orthovoltage X-ray treatment device, e.g., positioned to provide treatment to tissue on the retina, such as the macula.Type: ApplicationFiled: January 13, 2014Publication date: May 8, 2014Applicant: Oraya Therapeutics, Inc.Inventors: Michael Gertner, Mark Arnoldussen, Matt Herron, Junzhong Liang
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Publication number: 20140105362Abstract: A portable orthovoltage radiotherapy system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, the ocular structures are placed in a global coordinate system based on ocular imaging. In some embodiments, the ocular structures inside the global coordinate system lead to direction of an automated positioning system that is directed based on the ocular structures within the coordinate system.Type: ApplicationFiled: December 17, 2013Publication date: April 17, 2014Applicant: Oraya Therapeutics, Inc.Inventor: Michael Gertner
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Publication number: 20140037063Abstract: A method, code and system for planning the treatment a lesion on or adjacent to the retina of an eye of a patient are disclosed. There is first established at least two beam paths along which x-radiation is to be directed at the retinal lesion. Based on the known spectral and intensity characteristics of the beam, a total treatment time for irradiation along each beam paths is determined. From the coordinates of the optic nerve in the aligned eye position, there is determined the extent and duration of eye movement away from the aligned patient-eye position in a direction that moves the patient's optic nerve toward the irradiation beam that will be allowed during treatment, while still maintaining the radiation dose at the patient optic nerve below a predetermined dose level.Type: ApplicationFiled: July 23, 2013Publication date: February 6, 2014Applicant: Oraya Therapeutics, Inc.Inventors: Michael Gertner, Mark Arnoldussen, Erik Chell, Steven D. Hansen, Junzhong Liang
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Patent number: 8630388Abstract: Embodiments provide method and systems for determining or measuring objective eye alignment in an external-coordinate system so as to define a reference axis. Additional embodiments provide a method and system of aligning an objectively determined reference axis of the eye in a selected relationship to a therapeutic axis of an ophthalmic therapeutic apparatus and/or a diagnostic axis of an ophthalmic diagnostic apparatus. Embodiments provide a method and system for planning an ophthalmic treatment procedure based on objective eye alignment in an external-coordinate system so as to define a reference axis of an eye to be treated. The reference axis may be used to position a therapeutic energy component, for example, an orthovoltage X-ray treatment device, e.g., positioned to provide treatment to tissue on the retina, such as the macula.Type: GrantFiled: January 29, 2013Date of Patent: January 14, 2014Assignee: Oraya Therapeutics, Inc.Inventors: Michael Gertner, Mark Arnoldussen, Matt Herron, Junzhong Liang
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Patent number: 8611497Abstract: A portable orthovoltage radiotherapy system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, the ocular structures are placed in a global coordinate system based on ocular imaging. In some embodiments, the ocular structures inside the global coordinate system lead to direction of an automated positioning system that is directed based on the ocular structures within the coordinate system.Type: GrantFiled: November 14, 2011Date of Patent: December 17, 2013Assignee: Oraya Therapeutics, Inc.Inventor: Michael Gertner
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Publication number: 20130315374Abstract: Embodiments provide method and systems for determining alignment of a patient's body part, such as an eye, in an external coordinate system of a treatment or diagnostic device, such as a radiotherapy device, so as to define a reference axis for guiding device operation. Additional embodiments provide image-based methods and systems for aligning, tracking and monitoring motion of a body part and a treatment target in relation to a radiation beam axis. Particular ophthalmic embodiments provide method and systems including an eye-contact guide device and imaging system for aligning and tracking motion of an eye and ocular treatment target in relation to an orthovoltage X-ray beam axis, so as to monitor application of radiation to a lesion, such as a macular lesion of the retina.Type: ApplicationFiled: August 2, 2013Publication date: November 28, 2013Applicant: Oraya Therapeutics, Inc.Inventors: Michael Gertner, Mark Arnoldussen, Erik Chell, Steven D. Hansen, Matt Herron, Igor Koruga, Junzhong Liang
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Publication number: 20130243158Abstract: A radiosurgery system is described that delivers a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, ocular structures are placed in a global coordinate system, based on ocular imaging, which leads to direction of an automated positioning system. In some embodiments, the position of an ocular structure is tracked and related to a radiosurgery system. In some embodiments, a treatment plan is utilized for a specific disease to be treated and/or structures to be avoided. In some embodiments, a fiducial aids in positioning the system. In some embodiments, a reflection off the eye is used to aid in positioning. In some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments.Type: ApplicationFiled: May 13, 2013Publication date: September 19, 2013Applicant: Oraya Therapeutics, Inc.Inventors: Michael Gertner, Steven D. Hansen, Erik Chell, Matt Herron
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Patent number: 8512236Abstract: A system for securing a patient eye at a known position in an external coordinate system is disclosed. The system includes a head support for supporting the patient's head, an eye-contact device including a concave contact surface adapted to be placed against the front surface of a patient's eye, and a port in fluid communication with the contact surface, by which a vacuum can be applied to the device to remove air between the eye and the contact surface, to stabilize the position of the eye with respect to the contact device, and a biasing mechanism operatively connected to the contact device for biasing the contact device against the eye with a force sufficient to the hold the contact device against the eye, when the eye is stabilized with respect to the device by removal of air between the eye and the device's contact surface.Type: GrantFiled: February 6, 2008Date of Patent: August 20, 2013Assignee: Oraya Therapeutics, Inc.Inventors: Michael Gertner, Mark Arnoldussen, Matt Herron
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Patent number: 8506558Abstract: A method and system for performing an ocular irradiation procedure on a patient's eye is disclosed. The system includes a head support for supporting the patient's head, an eye-contact device attachable to the front portion of the patient's eye, to stabilize the position of the eye; and a position detector for determining the position of the contact device in the external coordinate system. A source of a collimated electromagnetic radiation beam in the system is controlled by a beam-positioning assembly for positioning the beam source such that the beam, when activated, is aimed along a selected path at a selected coordinate in the external coordinate system corresponding to a selected target region in the patient's eye.Type: GrantFiled: February 6, 2008Date of Patent: August 13, 2013Assignee: Oraya Therapeutics, Inc.Inventors: Michael Gertner, Mark Arnoldussen, Matt Herron
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Patent number: 8503609Abstract: Embodiments provide method and systems for determining alignment of a patient's body part, such as an eye, in an external coordinate system of a treatment or diagnostic device, such as a radiotherapy device, so as to define a reference axis for guiding device operation. Additional embodiments provide image-based methods and systems for aligning, tracking and monitoring motion of a body part and a treatment target in relation to a radiation beam axis. Particular ophthalmic embodiments provide method and systems including an eye-contact guide device and imaging system for aligning and tracking motion of an eye and ocular treatment target in relation to an orthovoltage X-ray beam axis, so as to monitor application of radiation to a lesion, such as a macular lesion of the retina.Type: GrantFiled: September 7, 2010Date of Patent: August 6, 2013Assignee: Oraya Therapeutics, Inc.Inventors: Michael Gertner, Mark Arnoldussen, Erik Chell, Steven D. Hansen, Matt Herron, Igor Koruga, Junzhong Liang