Patents Assigned to ORBUS AS
  • Patent number: 11473602
    Abstract: A hand crank cam lock for connecting medium to large sized display walls or boards including a hand crank disposed in a cam lock. The hand crank cam lock is configured to join two separate extrusions or frames together in a toolless manner. The hand crank cam lock locks these frames when the hand crank is turned clockwise, a plurality of hooks slide back along channels inside an outer body to grab the inner walls of a frame. This will in turn lock the hooks into place against the inner walls. The hand crank will only require half a turn to travel the required distance to lock the hooks into place and this half turn may be performed via a tool or by hand.
    Type: Grant
    Filed: February 26, 2020
    Date of Patent: October 18, 2022
    Assignee: Orbus, LCC
    Inventors: James J. Apostle, Drew A. Adams, Dean Alkas, Ryan W. Duever
  • Patent number: 11439612
    Abstract: Eflornithine is an agent that can be used to treat glioma, especially glioma of WHO Grade II or Grade III such as anaplastic glioma. Eflornithine can suppress or prevent mutations in glioma which can cause the glioma to progress to a higher grade. The present invention describes pharmaceutical compositions that contain eflornithine or a derivative, analog, or prodrug thereof. The pharmaceutical compositions can be prepared in a number of dosage forms and may contain another therapeutically active agent or an agent that enhances the therapeutic activity of the elformithine or the derivative, analog, or prodrug thereof. The present invention also describes a kit that includes dosage forms of pharmaceutical compositions according to the present invention.
    Type: Grant
    Filed: August 25, 2020
    Date of Patent: September 13, 2022
    Assignee: ORBUS THERAPEUTICS, INC.
    Inventors: Victor A. Levin, Noymi Yam, Alexander Vakoula
  • Patent number: 11403975
    Abstract: A display system, including a graphic display cover is described that includes an upper support frame configured to support the graphic display cover; a lower support frame configured to widen the graphic display cover; and a base frame configured to stabilize the graphic display cover. The base frame is anchored to the ground at multiple locations about the base frame. The upper support frame, the lower support frame and the base frame are collapsible and transportable.
    Type: Grant
    Filed: December 11, 2019
    Date of Patent: August 2, 2022
    Assignee: Orbus, LLC
    Inventors: James J. Apostle, Drew A. Adams, Dmitri Doubovikov
  • Publication number: 20210262500
    Abstract: A hand crank cam lock for connecting medium to large sized display walls or boards including a hand crank disposed in a cam lock. The hand crank cam lock is configured to join two separate extrusions or frames together in a toolless manner. The hand crank cam lock locks these frames when the hand crank is turned clockwise, a plurality of hooks slide back along channels inside an outer body to grab the inner walls of a frame. This will in turn lock the hooks into place against the inner walls. The hand crank will only require half a turn to travel the required distance to lock the hooks into place and this half turn may be performed via a tool or by hand.
    Type: Application
    Filed: February 26, 2020
    Publication date: August 26, 2021
    Applicant: Orbus, LLC
    Inventors: James J. Apostle, Drew A. Adams, Dean Alkas, Ryan W. Duever
  • Publication number: 20210183280
    Abstract: A display system, including a graphic display cover is described that includes an upper support frame configured to support the graphic display cover; a lower support frame configured to widen the graphic display cover; and a base frame configured to stabilize the graphic display cover. The base frame is anchored to the ground at multiple locations about the base frame. The upper support frame, the lower support frame and the base frame are collapsible and transportable.
    Type: Application
    Filed: December 11, 2019
    Publication date: June 17, 2021
    Applicant: Orbus, LLC
    Inventors: James J. Apostle, Drew A. Adams, Dmitri Doubovikov
  • Patent number: 10909890
    Abstract: A display system includes a rectangular frame that is surrounded on four sides and is open on two opposed faces. Two banners are disposed to cover the two open faces to enclose a space within the frame. At least one light emitting device is connected to the frame and disposed within the space. The two banners are backlit by the at least one light emitting device when each is in its respective extended position.
    Type: Grant
    Filed: February 25, 2020
    Date of Patent: February 2, 2021
    Assignee: Orbus, LLC
    Inventors: James J. Apostle, Drew A. Adams, Dmitri Doubovikov, Ryan W. Duever
  • Patent number: 10786470
    Abstract: Eflornithine is an agent that can be used to treat glioma, especially glioma of WHO Grade II or Grade III such as anaplastic glioma. Eflornithine can suppress or prevent mutations in glioma which can cause the glioma to progress to a higher grade. The present invention describes pharmaceutical compositions that contain eflornithine or a derivative, analog, or prodrug thereof. The pharmaceutical compositions can be prepared in a number of dosage forms and may contain another therapeutically active agent or an agent that enhances the therapeutic activity of the eflornithine or the derivative, analog, or prodrug thereof. The present invention also describes a kit that includes dosage forms of pharmaceutical compositions according to the present invention.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: September 29, 2020
    Assignee: ORBUS THERAPEUTICS, INC.
    Inventors: Victor A. Levin, Noymi Yam, Alexander Vakoula
  • Publication number: 20190091187
    Abstract: Eflornithine is an agent that can be used to treat glioma, especially glioma of WHO Grade II or Grade III such as anaplastic glioma. Eflornithine can suppress or prevent mutations in glioma which can cause the glioma to progress to a higher grade. Compositions and methods can include eflornithine or a derivative or analog of eflornithine, together with other agents such as conventional anti-neoplastic agents for treatment of glioma, inhibitors of polyamine transport, polyamine analogs, or S-adenosylmethionine decarboxylase inhibitors.
    Type: Application
    Filed: March 16, 2017
    Publication date: March 28, 2019
    Applicant: Orbus Therapeutics, Inc.
    Inventor: Victor A. LEVIN
  • Patent number: 9072723
    Abstract: The invention relates to a method for healing blood vessels by stimulating the formation of a confluent endothelial autologous cell layer in vivo on an implantable metallic stent having a lumen and a luminal surface, and an exterior surface. More specifically, the method includes implanting the stent with a coating in a patient in need of thereof; wherein the coating includes one or more layers of a matrix covalently adherent on said luminal and exterior surface of said stent containing one or more pharmaceutical substances on said exterior surface and a therapeutically effective amount of a single type of antibody, antibody fragments or combinations thereof being compatible to binding selectively to a specific cell surface antigen of circulating autologous endothelial progenitor cells in peripheral blood. In addition, genetically engineered endothelial progenitor cells can be captured on said luminal surface of stent in vivo, to proliferate to form rapidly a confluent endothelium in situ.
    Type: Grant
    Filed: August 20, 2012
    Date of Patent: July 7, 2015
    Assignee: ORBUS MEDICAL TECHNOLOGY INC
    Inventors: Michael John Bradley Kutryk, Robert J. Cottone, Jr., Stephen M. Rowland
  • Patent number: 8628466
    Abstract: A means for achieving enhanced erection includes a mounting attachment (10) to be placed onto the penis, e.g. in the form of a penis ring of a substantially elastic material. On the mounting attachment (10), one or more rows (14) of miniature vibrator motors (8 ABC) is/are provided, each row comprising at least three motors. For sequential pulsating operation of the motors (8 ABC) of the row(s) (14), an electric power supply arrangement (7) and an electronic control circuit (9) are provided. The control circuit (9) and the power supply arrangement (7) may be positioned on the mounting attachment (10). In one embodiment, piezoelectric foil strips (15 abc) are located underneath the vibrator motors (8 ABC) and are operated in a controlled relation to the motor operation for generating mechanical vibrations with a frequency that is higher than the frequency of the vibrator motors.
    Type: Grant
    Filed: November 23, 2009
    Date of Patent: January 14, 2014
    Assignee: Orbus AS
    Inventors: Birger Orten, Lasse Werner, Fredrik Askjem
  • Publication number: 20130172988
    Abstract: Compositions and methods are provided for producing a medical device such as a stent, a stent graft, a synthetic vascular graft, heart valves, coated with a biocompatible matrix which incorporates antibodies, antibody fragments, or small molecules, which recognize, bind to and/or interact with a progenitor cell surface antigen to immobilize the cells at the surface of the device. The coating on the device can also contain a compound or growth factor for promoting the progenitor endothelial cell to accelerate adherence, growth and differentiation of the bound cells into mature and functional endothelial cells on the surface of the device to prevent intimal hyperplasia. Methods for preparing such medical devices, compositions, and methods for treating a mammal with vascular disease such as restenosis, artherosclerosis or other types of vessel obstructions are disclosed.
    Type: Application
    Filed: October 1, 2012
    Publication date: July 4, 2013
    Applicant: Orbus Medical Technologies Inc.
    Inventors: Michael J. B. Kutryk, Robert J. Cottone, JR., Stephen M. Rowland, Michael A. Kuliszewski
  • Patent number: 8434963
    Abstract: A connector for rigidly engaging elongate structural members in a display structure includes a beam connection portion defined on a body and having a cavity. A semi-cylindrical guide surface of the cavity is adjacent to an opening. The opening has an elliptical shape in which the difference between a major and a minor axis is an offset distance. An eccentric fastener is rotatably disposed in the cavity and includes a head portion that protrudes from the opening and engages a hole of the elongate structural member, and a cam portion that is eccentrically disposed relative to the head portion and configured to engage the semi-cylindrical surface when the eccentric fastener is rotated relative to the connector.
    Type: Grant
    Filed: June 7, 2010
    Date of Patent: May 7, 2013
    Assignee: Orbus/P3
    Inventors: Dean Alkas, Michael Carrow
  • Publication number: 20110296660
    Abstract: A connector for rigidly engaging elongate structural members in a display structure includes a beam connection portion defined on a body and having a cavity. A semi-cylindrical guide surface of the cavity is adjacent to an opening. The opening has an elliptical shape in which the difference between a major and a minor axis is an offset distance. An eccentric fastener is rotatably disposed in the cavity and includes a head portion that protrudes from the opening and engages a hole of the elongate structural member, and a cam portion that is eccentrically disposed relative to the head portion and configured to engage the semi-cylindrical surface when the eccentric fastener is rotated relative to the connector.
    Type: Application
    Filed: June 7, 2010
    Publication date: December 8, 2011
    Applicant: ORBUS
    Inventors: Dean Alkas, Michael Carrow
  • Publication number: 20110288370
    Abstract: A means for achieving enhanced erection includes a mounting attachment (10) to be placed onto the penis, e.g. in the form of a penis ring of a substantially elastic material. On the mounting attachment (10), one or more rows (14) of miniature vibrator motors (8 ABC) is/are provided, each row comprising at least three motors. For sequential pulsating operation of the motors (8 ABC) of the row(s) (14), an electric power supply arrangement (7) and an electronic control circuit (9) are provided. The control circuit (9) and the power supply arrangement (7) may be positioned on the mounting attachment (10). In one embodiment, piezoelectric foil strips (15 abc) are located underneath the vibrator motors (8 ABC) and are operated in a controlled relation to the motor operation for generating mechanical vibrations with a frequency that is higher than the frequency of the vibrator motors.
    Type: Application
    Filed: November 23, 2009
    Publication date: November 24, 2011
    Applicant: ORBUS AS
    Inventors: Birger Orten, Lasse Werner, Fredrik Askjem
  • Publication number: 20090247603
    Abstract: The present invention is a new stable drug composition particularly suitable for use as an antihypercholesterolaemic or antihyperlipidaemic agent. The present invention is specifically a drug composition comprising a pharmaceutical, a complexing agent and a surfactant, and a method for manufacturing same. When applied to unstable drugs with low solubility and poor bioavailability, like HMG-CoA reductase inhibitors and especially atorvastatin calcium amorphous form, the resulting drug composition is more stable and is characterized by an improved dissolution profile.
    Type: Application
    Filed: December 23, 2005
    Publication date: October 1, 2009
    Applicant: Orbus Pharma, Inc.
    Inventor: Laxminarayan Joshi
  • Publication number: 20080051448
    Abstract: The present invention is a new stable extended release drug composition particularly suitable for use as an antihypercholesterolaemic or antihyperlipidaemic agent. The present invention is specifically a drug composition comprising a pharmaceutical, a complexing agent and a matrix-forming agent, and a method for manufacturing same. When applied to acid-labile drugs like HMG-CoA reductase inhibitors, the resulting drug composition is stabilized and is characterized by an extended-release profile.
    Type: Application
    Filed: August 13, 2007
    Publication date: February 28, 2008
    Applicant: Orbus Pharma, Inc.
    Inventor: Laxminarayan Joshi
  • Publication number: 20070213801
    Abstract: Compositions and methods are provided for producing a medical device such as a stent, a stent graft, a synthetic vascular graft, heart valves, coated with a biocompatible matrix which incorporates antibodies, antibody fragments, or small molecules, which recognize, bind to and/or interact with a progenitor cell surface antigen to immobilize the cells at the surface of the device. The coating on the device can also contain a compound or growth factor for promoting the progenitor endothelial cell to accelerate adherence, growth and differentiation of the bound cells into mature and functional endothelial cells on the surface of the device to prevent intimal hyperplasia. Methods for preparing such medical devices, compositions, and methods for treating a mammal with vascular disease such as restenosis, artherosclerosis or other types of vessel obstructions are disclosed.
    Type: Application
    Filed: July 7, 2006
    Publication date: September 13, 2007
    Applicant: Orbus Medical Technologies, Inc.
    Inventors: Michael John Kutryk, Robert Cottone, Stephen Rowland, Michael Kuliszewski
  • Publication number: 20070055367
    Abstract: Compositions and methods are provided for producing a medical device such as a stent, a stent graft, a synthetic vascular graft, heart valves, coated with a biocompatible matrix which incorporates antibodies, antibody fragments, or small molecules, which recognize, bind to and/or interact with a progenitor cell surface antigen to immobilize the cells at the surface of the device. The coating on the device can also contain a compound or growth factor for promoting the progenitor endothelial cell to accelerate adherence, growth and differentiation of the bound cells into mature and functional endothelial cells on the surface of the device to prevent intimal hyperplasia. Methods for preparing such medical devices, compositions, and methods for treating a mammal with vascular disease such as restenosis, artherosclerosis or other types of vessel obstructions are disclosed.
    Type: Application
    Filed: June 9, 2006
    Publication date: March 8, 2007
    Applicant: Orbus Medical Technologies, Inc.
    Inventors: Michael Kutryk, Robert Cottone, Stephen Rowland, Michael Kuliszewski
  • Publication number: 20070042017
    Abstract: Compositions and methods are provided for producing a medical device such as a stent, a stent graft, a synthetic vascular graft, heart valves, coated with a biocompatible matrix which incorporates antibodies, antibody fragments, or small molecules, which recognize, bind to and/or interact with a progenitor cell surface antigen to immobilize the cells at the surface of the device. The coating on the device can also contain a compound or growth factor for promoting the progenitor endothelial cell to accelerate adherence, growth and differentiation of the bound cells into mature and functional endothelial cells on the surface of the device to prevent intimal hyperplasia. Methods for preparing such medical devices, compositions, and methods for treating a mammal with vascular disease such as restenosis, artherosclerosis or other types of vessel obstructions are disclosed.
    Type: Application
    Filed: July 7, 2006
    Publication date: February 22, 2007
    Applicant: Orbus Medical Technologies, Inc.
    Inventors: Michael Kutryk, Robert Cottone, Stephen Rowland, Michael Kuliszewski
  • Publication number: 20060229277
    Abstract: The present invention relates to pharmaceutical compositions containing an HMG-CoA reductase inhibitor which are protected from destabilization in acidic environments by utilizing an inclusion complexing agent, and further relates to their preparation and to their use in the treatment of hypercholesterolemia and hyperlipidemia.
    Type: Application
    Filed: April 8, 2005
    Publication date: October 12, 2006
    Applicant: Orbus Pharma, Inc.
    Inventor: Laxminarayan Joshi