Patents Assigned to Orbus Therapeutics, Inc.
  • Formulations for administration of eflornithine
    Patent number: 11439612
    Abstract: Eflornithine is an agent that can be used to treat glioma, especially glioma of WHO Grade II or Grade III such as anaplastic glioma. Eflornithine can suppress or prevent mutations in glioma which can cause the glioma to progress to a higher grade. The present invention describes pharmaceutical compositions that contain eflornithine or a derivative, analog, or prodrug thereof. The pharmaceutical compositions can be prepared in a number of dosage forms and may contain another therapeutically active agent or an agent that enhances the therapeutic activity of the elformithine or the derivative, analog, or prodrug thereof. The present invention also describes a kit that includes dosage forms of pharmaceutical compositions according to the present invention.
    Type: Grant
    Filed: August 25, 2020
    Date of Patent: September 13, 2022
    Assignee: ORBUS THERAPEUTICS, INC.
    Inventors: Victor A. Levin, Noymi Yam, Alexander Vakoula
  • Formulations for administration of eflornithine
    Patent number: 10786470
    Abstract: Eflornithine is an agent that can be used to treat glioma, especially glioma of WHO Grade II or Grade III such as anaplastic glioma. Eflornithine can suppress or prevent mutations in glioma which can cause the glioma to progress to a higher grade. The present invention describes pharmaceutical compositions that contain eflornithine or a derivative, analog, or prodrug thereof. The pharmaceutical compositions can be prepared in a number of dosage forms and may contain another therapeutically active agent or an agent that enhances the therapeutic activity of the eflornithine or the derivative, analog, or prodrug thereof. The present invention also describes a kit that includes dosage forms of pharmaceutical compositions according to the present invention.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: September 29, 2020
    Assignee: ORBUS THERAPEUTICS, INC.
    Inventors: Victor A. Levin, Noymi Yam, Alexander Vakoula
  • COMPOSITIONS AND METHODS FOR USE OF EFLORNITHINE AND DERIVATIVES AND ANALOGS THEREOF TO TREAT CANCERS INCLUDING GLIOMAS
    Publication number: 20190091187
    Abstract: Eflornithine is an agent that can be used to treat glioma, especially glioma of WHO Grade II or Grade III such as anaplastic glioma. Eflornithine can suppress or prevent mutations in glioma which can cause the glioma to progress to a higher grade. Compositions and methods can include eflornithine or a derivative or analog of eflornithine, together with other agents such as conventional anti-neoplastic agents for treatment of glioma, inhibitors of polyamine transport, polyamine analogs, or S-adenosylmethionine decarboxylase inhibitors.
    Type: Application
    Filed: March 16, 2017
    Publication date: March 28, 2019
    Applicant: Orbus Therapeutics, Inc.
    Inventor: Victor A. LEVIN