Patents Assigned to OrbusNeich Medical, Inc.
-
Medical device for implantation into luminal structures incorporating corrugated structural elements
Patent number: 9980835Abstract: Expandable scaffolds or stents include circumferential elements having a corrugated pattern, which can include a plurality of linear or nonlinear segments. The corrugated pattern distributes stress more uniformly along the circumferential elements, improves radial strength of the scaffolds, reduces acute recoil after deployment, and reduces creep. The scaffolds can be made from a bioabsorbable material.Type: GrantFiled: October 22, 2014Date of Patent: May 29, 2018Assignee: ORBUSNEICH MEDICAL INC.Inventors: John Pazienza, Robert J Cottone, Jennifer Ippolito, Mohamad Ike Juman, Dennis Liong -
Patent number: 9821093Abstract: A medical device for implantation into vessels or luminal structures within the body is provided, which stimulates positive blood vessel remodeling. The medical device, such as a stent and a synthetic graft, is coated with a pharmaceutical composition consisting of a controlled-release matrix and one or more pharmaceutical substances for direct delivery of drugs to surrounding tissues. The coating on the medical device further comprises a ligand such as a peptide, an antibody or a small molecule for capturing progenitor endothelial cells in the blood contacting surface of the device for restoring an endothelium at the site of injury. In particular, the drug-coated stents are for use, for example, in balloon angioplasty procedures for preventing or inhibiting restenosis.Type: GrantFiled: April 23, 2013Date of Patent: November 21, 2017Assignee: OrbusNeich Medical, Inc.Inventors: Robert John Cottone, Jr., Stephen M. Rowland, Sherry Parker
-
Patent number: 9724864Abstract: A method for fabricating an embodiment of a medical device comprising the steps of: preparing a biodegradable polymeric structure; coating the biodegradable polymeric structure with a polymeric coat including a pharmacological or biological agent; cutting the structure into patterns configured to allow for crimping of the cut structure and expansion of the cut structure after crimping into a deployed configuration.Type: GrantFiled: March 5, 2014Date of Patent: August 8, 2017Assignee: OrbusNeich Medical, Inc.Inventors: Robert J. Cottone, G. Lawrence Thatcher
-
Patent number: 9662416Abstract: A biodegradable and biocompatible nontoxic polymeric composition is provided which includes a base material such as a crystallizable polymer, copolymer, or terpolymer, and a copolymer or terpolymer additive. Medical devices manufactured from the composition are also provided.Type: GrantFiled: November 17, 2014Date of Patent: May 30, 2017Assignee: OrbusNeich Medical, Inc.Inventors: G. Lawrence Thatcher, Robert J. Cottone
-
Patent number: 9642947Abstract: A biodegradable and biocompatible nontoxic polymeric composition is provided which includes a base material such as a crystallizable polymer, copolymer, or terpolymer, and a copolymer or terpolymer additive. Medical devices manufactured from the composition are also provided.Type: GrantFiled: October 20, 2016Date of Patent: May 9, 2017Assignee: OrbusNeich Medical, Inc.Inventors: G. Lawrence Thatcher, Robert J. Cottone
-
Patent number: 9642945Abstract: A biodegradable and biocompatible nontoxic polymeric composition is provided which includes a base material such as a crystallizable polymer, copolymer, or terpolymer, and a copolymer or terpolymer additive. Medical devices manufactured from the composition are also provided.Type: GrantFiled: October 20, 2016Date of Patent: May 9, 2017Assignee: OrbusNeich Medical, Inc.Inventors: G. Lawrence Thatcher, Robert J. Cottone
-
Patent number: 9629940Abstract: A biodegradable and biocompatible nontoxic polymeric composition is provided which includes a base material such as a crystallizable polymer, copolymer, or terpolymer, and a copolymer or terpolymer additive. Medical devices manufactured from the composition are also provided.Type: GrantFiled: November 17, 2014Date of Patent: April 25, 2017Assignee: OrbusNeich Medical, Inc.Inventors: G. Lawrence Thatcher, Robert J. Cottone
-
Patent number: 9572693Abstract: The self-expanding stent of the present invention provides for a transition zone between the main body of the stent and the end zone, comprising a plurality of n-sided polygons where the surface area of the adjacent polygons in the transition zone is unequal. In one embodiment, the surface area of the polygons in the transition zone increases circumferentially across the transition zone in a clockwise or counterclockwise manner. The polygons are formed from two pairs of undulations which are connected by segments. The bending moment of the undulations is equal within each polygon and constant across the transition zone.Type: GrantFiled: May 13, 2010Date of Patent: February 21, 2017Assignee: Orbusneich Medical, Inc.Inventors: Robert J. Cottone, Shusheng Ye
-
Patent number: 9555166Abstract: The invention relates to a method for healing blood vessels by stimulating the formation of a confluent endothelial autologous cell layer in vivo on an implantable metallic stent having a lumen and a luminal surface, and an exterior surface. More specifically, the method includes implanting the stent with a coating in a patient in need of thereof; wherein the coating includes one or more layers of a matrix covalently adherent on said luminal and exterior surface of said stent containing one or more pharmaceutical substances on said exterior surface and a therapeutically effective amount of a single type of antibody, antibody fragments or combinations thereof being compatible to binding selectively to a specific cell surface antigen of circulating autologous endothelial progenitor cells in peripheral blood. In addition, genetically engineered endothelial progenitor cells can be captured on said luminal surface of stent in vivo, to proliferate to form rapidly a confluent endothelium in situ.Type: GrantFiled: June 5, 2015Date of Patent: January 31, 2017Assignee: OrbusNeich Medical Inc.Inventors: Michael John Bradley Kutryk, Robert John Cottone, Jr., Stephen Maxwell Rowland
-
Patent number: 9522217Abstract: Therapeutic and drug delivery systems are provided in the form of medical devices with coatings for capturing and immobilizing target cells such as circulating progenitor or genetically-altered mammalian cells in vivo. The genetically-altered cells are transfected with genetic material for expressing a marker gene and a therapeutic gene in a constitutively or controlled manner. The marker gene is a cell membrane antigen not found in circulating cells in the blood stream and therapeutic gene encodes a peptide for the treatment of disease, such as, vascular disease and cancer. The coating on the medical device may be a biocompatible matrix comprising at least one type of ligand, such as antibodies, antibody fragments, other peptides and small molecules, which recognize and bind the target cells. The therapeutic and/or drug delivery systems may be provided with a signal source such as activator molecules for stimulating the modified cells to express and secrete the desired marker and therapeutic gene products.Type: GrantFiled: April 30, 2004Date of Patent: December 20, 2016Assignee: OrbusNeich Medical, Inc.Inventors: Michael J. B. Kutryk, Robert J. Cottone, Jr., Stephen M. Rowland
-
Publication number: 20160287708Abstract: A medical device for implantation into vessels or luminal structures within the body is provided, which stimulates positive blood vessel remodeling. The medical device, such as a stent and a synthetic graft, is coated with a pharmaceutical composition consisting of a controlled-release matrix and one or more pharmaceutical substances for direct delivery of drugs to surrounding tissues. The coating on the medical device further comprises a ligand such as a peptide, an antibody or a small molecule for capturing progenitor endothelial cells in the blood contacting surface of the device for restoring an endothelium at the site of injury. In particular, the drug-coated stents are for use, for example, in balloon angioplasty procedures for preventing or inhibiting restenosis.Type: ApplicationFiled: November 20, 2006Publication date: October 6, 2016Applicant: OrbusNeich Medical, Inc.Inventors: Robert John Cottone, JR., Stephen M. Rowland, Sherry Parker
-
Patent number: 9427344Abstract: In embodiments there is described a cardiovascular tube-shaped lockable and expandable bioabsorbable scaffold having a low immunogenicity manufactured from a crystallizable bioabsorbable polymer composition or blend.Type: GrantFiled: October 14, 2014Date of Patent: August 30, 2016Assignee: Orbusneich Medical Inc.Inventors: Robert J. Cottone, Shusheng Ye, John Pazienza
-
Patent number: 9364565Abstract: Therapeutic and drug delivery systems are provided in the form of medical devices with coatings for capturing and immobilizing target cells such as circulating progenitor or genetically-altered mammalian cells in vivo. The genetically-altered cells are transfected with genetic material for expressing a marker gene and at least one therapeutic gene in a constitutively or controlled manner. The marker gene is a cell membrane antigen not found in circulating cells in the blood stream and therapeutic gene encodes a peptide for the treatment of disease, such as, vascular disease and cancer. The coating on the medical device may be a biocompatible matrix comprising at least one type of ligand, such as antibodies, antibody fragments, other peptides and small molecules, which recognize and bind the target cells.Type: GrantFiled: April 29, 2005Date of Patent: June 14, 2016Assignee: OrbusNeich Medical, Inc.Inventors: Michael John Bradley Kutryk, Robert J. Cottone, Jr., Stephen M. Rowland
-
Patent number: 9320829Abstract: A medical device for implantation into vessels or luminal structures within the body is provided, which stimulates positive blood vessel remodeling. The medical device, such as a stent and a synthetic graft, is provided with a coating with a pharmaceutical composition containing a controlled-release matrix and one or more pharmaceutical substances for direct delivery of drugs to surrounding tissues. The coating on the medical device further comprises one or more barrier layers, and a ligand such as a peptide, an antibody or a small molecule for capturing progenitor endothelial cells in the blood contacting surface of the device for restoring an endothelium at the site of injury. In particular, the drug-coated stents are for use, for example, in balloon angioplasty procedures for preventing or inhibiting restenosis.Type: GrantFiled: December 29, 2011Date of Patent: April 26, 2016Assignee: ORBUSNEICH MEDICAL, INC.Inventors: Robert J. Cottone, Jr., Margaret Yoklavich, Sherry Parker
-
Patent number: 9259338Abstract: In embodiments there is described a cardiovascular tube-shaped lockable and expandable bioabsorbable scaffold having a low immunogenicity manufactured from a crystallizable bioabsorbable polymer composition or blend.Type: GrantFiled: July 29, 2014Date of Patent: February 16, 2016Assignee: ORBUSNEICH MEDICAL, INC.Inventors: Robert J. Cottone, Shusheng Ye, John Pazienza
-
Patent number: 9211205Abstract: A biodegradable, bioabsorbable medical device with a coating for capturing progenitor endothelial cells in vivo and delivering a therapeutic agent at the site of implantation. The coating on the medical device is provided with a bioabsorbable polymer composition such as a bioabsorbable polymer, copolymer, or terpolymer, and a copolymer or terpolymer additive for controlling the rate of delivery of the therapeutic agent.Type: GrantFiled: January 17, 2014Date of Patent: December 15, 2015Assignee: ORBUSNEICH MEDICAL, INC.Inventor: Robert J. Cottone
-
Patent number: 8968385Abstract: An expandable stent comprised of a plurality of helical segments is disclosed. In one embodiment, the stent is generally cylindrical in shape having a cylindrical axis, and comprises a first and second set of helical segments. The helical segments in the first set are substantially parallel and have a first pitch forming a first helical angle with respect to the cylindrical axis. The helical segments in the second set are also generally parallel to each other and form a second pitch that differs from the first pitch, thereby forming a second helical angle with respect to the cylindrical axis. In an alternative embodiment, the stent comprises one set of helical segments and a plurality of circumferential elements that are joined together by the helical segments to form a plurality of cylindrical elements which are joined together to form a stent body. The stent may also have endzones.Type: GrantFiled: July 24, 2008Date of Patent: March 3, 2015Assignee: Orbusneich Medical, Inc.Inventors: Scott J. Addonizio, David L. Camp, Jr., Gary J. Becker, John D. Pazienza
-
Publication number: 20150028513Abstract: A method for fabricating an embodiment of a medical device comprising the steps of: preparing a biodegradable polymeric structure; coating the biodegradable polymeric structure with a polymeric coat including a pharmacological or biological agent; cutting the structure into patterns configured to allow for crimping of the cut structure and expansion of the cut structure after crimping into a deployed configuration.Type: ApplicationFiled: March 5, 2014Publication date: January 29, 2015Applicant: ORBUSNEICH MEDICAL, INC.Inventor: Robert J. Cottone
-
Patent number: 8870942Abstract: In embodiments there is described a cardiovascular tube-shaped lockable and expandable bioabsorbable scaffold having a low immunogenicity manufactured from a crystallizable bioabsorbable polymer composition or blend.Type: GrantFiled: January 4, 2013Date of Patent: October 28, 2014Assignee: Orbusneich Medical Inc.Inventors: Robert J. Cottone, Shusheng Ye, John Pazienza
-
Patent number: 8834557Abstract: In embodiments there is described a cardiovascular tube-shaped lockable and expandable bioabsorbable scaffold having a low immunogenicity manufactured from a crystallizable bioabsorbable polymer composition or blend.Type: GrantFiled: January 10, 2013Date of Patent: September 16, 2014Assignee: OrbusNeich Medical, Inc.Inventors: Robert J. Cottone, Shusheng Ye, John Pazienza