Patents Assigned to Orca Biosystems, Inc.
  • Publication number: 20250332595
    Abstract: Described are systems and methods for particle sorting. An array may comprise a substrate with a first surface and a second surface opposite to the first surface. The substrate may comprise a plurality of pores defining lumens extending from the first surface to the second surface. The plurality of pores can be configured to receive a sample solution comprising a plurality of particles. The array may further comprise a surface material provided at or adjacent to the first or second surfaces. The surface material may comprise a plurality of materials that are configured to modify a wetting behavior of the sample solution or the plurality of particles at or adjacent to said first or second surfaces, such that one of the first or second surfaces is hydrophilic, and the other of the first or second surfaces is hydrophobic.
    Type: Application
    Filed: April 10, 2025
    Publication date: October 30, 2025
    Applicant: Orca Biosystems, Inc.
    Inventors: Qiong PAN, Ivan K. DIMOV
  • Publication number: 20250235862
    Abstract: This disclosure provides methods and apparatuses for sorting target particles. In various embodiments, the disclosure provides a cassette for sorting target particles, methods for sorting target particles, methods of loading a microchannel for maintaining sample material viability, methods of quantifying sample material, and an optical apparatus for laser scanning and particle sorting.
    Type: Application
    Filed: January 10, 2025
    Publication date: July 24, 2025
    Applicant: Orca Biosystems, Inc.
    Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Lagnajeet Pradhan
  • Patent number: 12226770
    Abstract: This disclosure provides methods and apparatuses for sorting target particles. In various embodiments, the disclosure provides a cassette for sorting target particles, methods for sorting target particles, methods of loading a microchannel for maintaining sample material viability, methods of quantifying sample material, and an optical apparatus for laser scanning and particle sorting.
    Type: Grant
    Filed: August 4, 2023
    Date of Patent: February 18, 2025
    Assignee: Orca Biosystems, Inc.
    Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Lagnajeet Pradhan
  • Patent number: 12011461
    Abstract: The present disclosure provides distinct therapeutic populations of cells that form a pharmaceutical composition useful in hematopoietic stem/progenitor cell transplant. For example, the present disclosure provides a therapeutic population of cells, comprising an enriched population of hematopoietic stem/progenitor cells, memory T cells, regulatory T cells, and wherein the population of cells is depleted of naïve conventional ??-T cells. The present disclosure further provides methods of treatment using the therapeutic population of cells. In other embodiments, the present disclosure provides methods of producing a therapeutic population of cells.
    Type: Grant
    Filed: November 6, 2020
    Date of Patent: June 18, 2024
    Assignee: Orca Biosystems, Inc.
    Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Kevin Sheehan
  • Publication number: 20240075471
    Abstract: This disclosure provides methods and apparatuses for sorting target particles. In various embodiments, the disclosure provides a cassette for sorting target particles, methods for sorting target particles, methods of loading a microchannel for maintaining sample material viability, methods of quantifying sample material, and an optical apparatus for laser scanning and particle sorting.
    Type: Application
    Filed: August 4, 2023
    Publication date: March 7, 2024
    Applicant: Orca Biosystems, Inc.
    Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Lagnajeet Pradhan
  • Patent number: 11759779
    Abstract: This disclosure provides methods and apparatuses for sorting target particles. In various embodiments, the disclosure provides a cassette for sorting target particles, methods for sorting target particles, methods of loading a microchannel for maintaining sample material viability, methods of quantifying sample material, and an optical apparatus for laser scanning and particle sorting.
    Type: Grant
    Filed: September 12, 2022
    Date of Patent: September 19, 2023
    Assignee: Orca Biosystems, Inc.
    Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Lagnajeet Pradhan
  • Patent number: 11471885
    Abstract: This disclosure provides methods and apparatuses for sorting target particles. In various embodiments, the disclosure provides a cassette for sorting target particles, methods for sorting target particles, methods of loading a microchannel for maintaining sample material viability, methods of quantifying sample material, and an optical apparatus for laser scanning and particle sorting.
    Type: Grant
    Filed: June 16, 2020
    Date of Patent: October 18, 2022
    Assignee: Orca Biosystems, Inc.
    Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Lagnajeet Pradhan
  • Patent number: 10857183
    Abstract: The present disclosure provides distinct therapeutic populations of cells that form a pharmaceutical composition useful in hematopoietic stem/progenitor cell transplant. For example, the present disclosure provides a therapeutic population of cells, comprising an enriched population of hematopoietic stem/progenitor cells, memory T cells, regulatory T cells, and wherein the population of cells is depleted of naïve conventional ??-T cells. The present disclosure further provides methods of treatment using the therapeutic population of cells. In other embodiments, the present disclosure provides methods of producing a therapeutic population of cells.
    Type: Grant
    Filed: April 18, 2019
    Date of Patent: December 8, 2020
    Assignee: ORCA BIOSYSTEMS, INC.
    Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Kevin Sheehan
  • Patent number: 10722885
    Abstract: This disclosure provides methods and apparatuses for sorting target particles. In various embodiments, the disclosure provides a cassette for sorting target particles, methods for sorting target particles, methods of loading a microchannel for maintaining sample material viability, methods of quantifying sample material, and an optical apparatus for laser scanning and particle sorting.
    Type: Grant
    Filed: May 29, 2019
    Date of Patent: July 28, 2020
    Assignee: ORCA BIOSYSTEMS, INC.
    Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Lagnajeet Pradhan
  • Patent number: 10350595
    Abstract: This disclosure provides methods and apparatuses for sorting target particles. In various embodiments, the disclosure provides a cassette for sorting target particles, methods for sorting target particles, methods of loading a microchannel for maintaining sample material viability, methods of quantifying sample material, and an optical apparatus for laser scanning and particle sorting.
    Type: Grant
    Filed: July 24, 2018
    Date of Patent: July 16, 2019
    Assignee: Orca Biosystems, Inc.
    Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Lagnajeet Pradhan
  • Patent number: 10300090
    Abstract: The present disclosure provides distinct therapeutic populations of cells that form a pharmaceutical composition useful in hematopoietic stem/progenitor cell transplant. For example, the present disclosure provides a therapeutic population of cells, comprising an enriched population of hematopoietic stem/progenitor cells, memory T cells, regulatory T cells, and wherein the population of cells is depleted of naïve conventional ??-T cells. The present disclosure further provides methods of treatment using the therapeutic population of cells. In other embodiments, the present disclosure provides methods of producing a therapeutic population of cells.
    Type: Grant
    Filed: March 15, 2018
    Date of Patent: May 28, 2019
    Assignee: Orca Biosystems, Inc.
    Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Kevin Sheehan