Patents Assigned to Orca Biosystems, Inc.
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Publication number: 20250332595Abstract: Described are systems and methods for particle sorting. An array may comprise a substrate with a first surface and a second surface opposite to the first surface. The substrate may comprise a plurality of pores defining lumens extending from the first surface to the second surface. The plurality of pores can be configured to receive a sample solution comprising a plurality of particles. The array may further comprise a surface material provided at or adjacent to the first or second surfaces. The surface material may comprise a plurality of materials that are configured to modify a wetting behavior of the sample solution or the plurality of particles at or adjacent to said first or second surfaces, such that one of the first or second surfaces is hydrophilic, and the other of the first or second surfaces is hydrophobic.Type: ApplicationFiled: April 10, 2025Publication date: October 30, 2025Applicant: Orca Biosystems, Inc.Inventors: Qiong PAN, Ivan K. DIMOV
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Publication number: 20250235862Abstract: This disclosure provides methods and apparatuses for sorting target particles. In various embodiments, the disclosure provides a cassette for sorting target particles, methods for sorting target particles, methods of loading a microchannel for maintaining sample material viability, methods of quantifying sample material, and an optical apparatus for laser scanning and particle sorting.Type: ApplicationFiled: January 10, 2025Publication date: July 24, 2025Applicant: Orca Biosystems, Inc.Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Lagnajeet Pradhan
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Patent number: 12226770Abstract: This disclosure provides methods and apparatuses for sorting target particles. In various embodiments, the disclosure provides a cassette for sorting target particles, methods for sorting target particles, methods of loading a microchannel for maintaining sample material viability, methods of quantifying sample material, and an optical apparatus for laser scanning and particle sorting.Type: GrantFiled: August 4, 2023Date of Patent: February 18, 2025Assignee: Orca Biosystems, Inc.Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Lagnajeet Pradhan
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Patent number: 12011461Abstract: The present disclosure provides distinct therapeutic populations of cells that form a pharmaceutical composition useful in hematopoietic stem/progenitor cell transplant. For example, the present disclosure provides a therapeutic population of cells, comprising an enriched population of hematopoietic stem/progenitor cells, memory T cells, regulatory T cells, and wherein the population of cells is depleted of naïve conventional ??-T cells. The present disclosure further provides methods of treatment using the therapeutic population of cells. In other embodiments, the present disclosure provides methods of producing a therapeutic population of cells.Type: GrantFiled: November 6, 2020Date of Patent: June 18, 2024Assignee: Orca Biosystems, Inc.Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Kevin Sheehan
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Publication number: 20240075471Abstract: This disclosure provides methods and apparatuses for sorting target particles. In various embodiments, the disclosure provides a cassette for sorting target particles, methods for sorting target particles, methods of loading a microchannel for maintaining sample material viability, methods of quantifying sample material, and an optical apparatus for laser scanning and particle sorting.Type: ApplicationFiled: August 4, 2023Publication date: March 7, 2024Applicant: Orca Biosystems, Inc.Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Lagnajeet Pradhan
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Patent number: 11759779Abstract: This disclosure provides methods and apparatuses for sorting target particles. In various embodiments, the disclosure provides a cassette for sorting target particles, methods for sorting target particles, methods of loading a microchannel for maintaining sample material viability, methods of quantifying sample material, and an optical apparatus for laser scanning and particle sorting.Type: GrantFiled: September 12, 2022Date of Patent: September 19, 2023Assignee: Orca Biosystems, Inc.Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Lagnajeet Pradhan
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Patent number: 11471885Abstract: This disclosure provides methods and apparatuses for sorting target particles. In various embodiments, the disclosure provides a cassette for sorting target particles, methods for sorting target particles, methods of loading a microchannel for maintaining sample material viability, methods of quantifying sample material, and an optical apparatus for laser scanning and particle sorting.Type: GrantFiled: June 16, 2020Date of Patent: October 18, 2022Assignee: Orca Biosystems, Inc.Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Lagnajeet Pradhan
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Patent number: 10857183Abstract: The present disclosure provides distinct therapeutic populations of cells that form a pharmaceutical composition useful in hematopoietic stem/progenitor cell transplant. For example, the present disclosure provides a therapeutic population of cells, comprising an enriched population of hematopoietic stem/progenitor cells, memory T cells, regulatory T cells, and wherein the population of cells is depleted of naïve conventional ??-T cells. The present disclosure further provides methods of treatment using the therapeutic population of cells. In other embodiments, the present disclosure provides methods of producing a therapeutic population of cells.Type: GrantFiled: April 18, 2019Date of Patent: December 8, 2020Assignee: ORCA BIOSYSTEMS, INC.Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Kevin Sheehan
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Patent number: 10722885Abstract: This disclosure provides methods and apparatuses for sorting target particles. In various embodiments, the disclosure provides a cassette for sorting target particles, methods for sorting target particles, methods of loading a microchannel for maintaining sample material viability, methods of quantifying sample material, and an optical apparatus for laser scanning and particle sorting.Type: GrantFiled: May 29, 2019Date of Patent: July 28, 2020Assignee: ORCA BIOSYSTEMS, INC.Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Lagnajeet Pradhan
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Patent number: 10350595Abstract: This disclosure provides methods and apparatuses for sorting target particles. In various embodiments, the disclosure provides a cassette for sorting target particles, methods for sorting target particles, methods of loading a microchannel for maintaining sample material viability, methods of quantifying sample material, and an optical apparatus for laser scanning and particle sorting.Type: GrantFiled: July 24, 2018Date of Patent: July 16, 2019Assignee: Orca Biosystems, Inc.Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Lagnajeet Pradhan
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Patent number: 10300090Abstract: The present disclosure provides distinct therapeutic populations of cells that form a pharmaceutical composition useful in hematopoietic stem/progenitor cell transplant. For example, the present disclosure provides a therapeutic population of cells, comprising an enriched population of hematopoietic stem/progenitor cells, memory T cells, regulatory T cells, and wherein the population of cells is depleted of naïve conventional ??-T cells. The present disclosure further provides methods of treatment using the therapeutic population of cells. In other embodiments, the present disclosure provides methods of producing a therapeutic population of cells.Type: GrantFiled: March 15, 2018Date of Patent: May 28, 2019Assignee: Orca Biosystems, Inc.Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Kevin Sheehan