Patents Assigned to Orchid Chemicals & Pharmaceuticals Ltd.
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Publication number: 20060094703Abstract: A process for the preparation of cefdinir of the formula (I) the said process comprising the steps of: i) condensing 7-amino-3-cephem-4-carboxylic acid of the formula (XII) wherein R1 is as defined above with compound of the formula (XIII) in the presence of a tertiary amine and an organic solvent, followed by treatment with a base to produce a salt of compound formula (XIV), wherein M+ is a counter ion and ii) hydrolyzing the compound of the formula (XIV) using an acid in the presence of a solvent to produce cefdinir of formula (I).Type: ApplicationFiled: November 10, 2003Publication date: May 4, 2006Applicant: Orchid Chemicals and Pharmaceuticals Ltd.Inventors: Pandurang Deshpande, Bhausaheb Khadangale, Chandrasekaran Ramasubbu
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Publication number: 20060094872Abstract: An improved process for the preparation of Ceftiofar sodium of formula (I) without isolating intermediate compound of formula (IV)Type: ApplicationFiled: December 6, 2005Publication date: May 4, 2006Applicant: Orchid Chemicals & Pharmaceuticals Ltd.Inventors: Udayampalayam Senthilkumar, Kanagaraj Sureshkumar, Singaravel Mohan, Lakshminarayanan Arunkumar, Bakthavachalam Ananthan
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Publication number: 20060058281Abstract: An improved one-pot process for the preparation of Ceftiofur of the formula (I) or its salt, without isolating intermediate compound.Type: ApplicationFiled: October 3, 2005Publication date: March 16, 2006Applicant: Orchid Chemicals & Pharmaceuticals Ltd.Inventors: Udayampalayam Senthilkumar, Kanagaraj Sureshkumar, Singaravel Mohan, Lakshminarayanan Arunkumar
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Publication number: 20050228176Abstract: An improved process for the purification of tazobactam or its derivatives of the formula (I) wherein R represents hydrogen, C1-C6alkyl, p-methoxybenzyl, o-nitrobenzyl, p-nitrobenzyl, o-chlorobenzyl, benzyl or diphenylmethyl, which comprises the steps of: i) slurrying the compound of formula (I) containing the impurity of the formula (V) using a solvent in the presence or absence of tartaric acid with or without the presence of water at 20-50° C.Type: ApplicationFiled: April 5, 2005Publication date: October 13, 2005Applicant: Orchid Chemicals and Pharmaceuticals Ltd.Inventors: Andrew Gnanaprakasam, Udayampalayam Senthilkumar, Gaddam Reddy
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Publication number: 20050215781Abstract: The present invention relates to novel polymorph of cefdinir represented by formula (I). More particularly, the present invention relates to novel crystalline form (Crystal D) of cefdinir. The present invention also provides a process for the preparation of novel crystalline form (Crystal D) of cefdinir.Type: ApplicationFiled: March 15, 2005Publication date: September 29, 2005Applicant: ORCHID CHEMICALS & PHARMACEUTICALS LTD.Inventors: Ramasubbu Chandrasekaran, Krishnan Senthilkumar, Saravan Murugan, Venkatasubba Sangaraju, Gaddam Reddy
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Publication number: 20050203102Abstract: The present invention provides novel compounds of the general formula (I) and their pharmaceutically acceptable salts. The present invention more particularly provides novel oxazolidinone derivatives of the general formula (I).Type: ApplicationFiled: March 9, 2005Publication date: September 15, 2005Applicant: ORCHID CHEMICALS & PHARMACEUTICALS LTD.Inventors: Shiv Agarwal, Surendrakumar Pandey, Gajendra Singh, Santhanagopalan Chithra, Matte Samuel
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Patent number: 6881837Abstract: This invention relates to the production of S-adenosyl-L-methionine by means of a chemical process wherein enrichment of the bioactive (S,S)-isomer is achieved. The process is simple, efficient, economical and reproducible on large scale.Type: GrantFiled: June 7, 2001Date of Patent: April 19, 2005Assignee: Orchid Chemicals & Pharmaceuticals Ltd.Inventors: Pandurang Balwant Deshpande, Udayampalam Palanisamy Senthilkumar, Ramar Padmanabhan
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Publication number: 20050080070Abstract: A process for the preparation of cephalosporin antibiotic of the formula (I) which comprises: (i) activating the compound of formula (III) as acid halide in an organic solvent (ii) treating the reaction mass obtained from step (i) with water (iii) separating the organic layer containing the reactive derivative of formula (III) and condensing it with 7-amino cephalosporin derivative by maintaining the pH in the range 5.0-10.0 using an inorganic base of the formula (XV), and iv) cyclizing the compound of formula (XVI) with thiourea in the presence of solvent and salt of organic or inorganic acid at a temperature in the range of ?50 to +50° C. to produce compound of formula (I).Type: ApplicationFiled: August 23, 2004Publication date: April 14, 2005Applicant: ORCHID CHEMICALS & PHARMACEUTICALS LTD.Inventors: Pandurang Deshpande, Udayampalayam Senthilkumar, Velladurai Hero
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Publication number: 20050080072Abstract: The present invention relates to a process for the preparation of biologically active thiazepine derivative. The present invention more particularly, relates to an improved process for the preparation of dibenzo[b,f][1,4]thiazepine derivative of formula (I).Type: ApplicationFiled: August 26, 2004Publication date: April 14, 2005Applicant: ORCHID CHEMICALS & PHARMACEUTICALS LTD.Inventors: Pandurang Deshpande, Anil Holkar, Omprakash Gudaparthi, Jothi Kumar
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Publication number: 20050070705Abstract: A process for the preparation of 3-methylcepham-4-carboxylate of the formula (I). wherein R2 and R3 may be same or different and represent hydrogen, halogen, amino, alkyl, phenacetamido, substituted acetamido, phthalimido with a proviso that both R2 and R3 are not NH2, phenacetamido, phthalimido and the like; R1 represents a lower alkyl, p-methoxybenzyl, p-nitrobenzyl, o-nitrobenzyl, o-methoxybenzyl, o-chlorobenzyl or diphenylmethyl group, or a suitable ester residue which can be deprotected at a latter stage, L represents a leaving group; which comprises cyclizing the compound of formula (III) using a cyclizing agent in the presence of organic or inorganic nitrites and a solvent at a temperature in the range of ?40° C. to +60° C. to obtain compound of formula (I).Type: ApplicationFiled: August 23, 2004Publication date: March 31, 2005Applicant: ORCHID CHEMICALS & PHARMACEUTICALS LTD.Inventors: Pandurang Deshpande, Udayampalayam Senthilkumar, Andrew Gnanaprakasam, Kanagaraj Sureshkumar
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Publication number: 20050027118Abstract: An improved process for the preparation of ceftriaxone sodium comprising the steps of: i) reacting the 3-cephem derivative of formula (II) ?with halo acid derivative of formula (III) ?wherein X represents halogen and Y represent halogen in the presence of silylating agent and methylene chloride at ?25 to 10° C., to produce (IV), ii) quenching the reaction by pouring the reaction mixture into water or in a aqueous solution of sodium carbonate, iii) preparing sodium salt solution of (IV) by adding sodium carbonate and separating the organic layer, iv) cyclizing the sodium salt of (IV) in the aqueous solution with thiourea at a temperature in the range of 0 to 30° C., v) adjusting the pH to 1.5 to 2.5 to precipitate the ceftriaxone free acid, vi) converting the ceftriaxone free acid to sodium salt using sodium-2-ethyl hexanoate in water and vii) precipitating and isolating the ceftriaxone sodium.Type: ApplicationFiled: June 16, 2004Publication date: February 3, 2005Applicant: ORCHID CHEMICALS & PHARMACEUTICALS, LTD.Inventors: Pandurang Deshpande, Prabhat Sahoo, Anandam Vempali, Srinivasu Ghanta
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Publication number: 20040204466Abstract: Accordingly, the present invention provides a method of treating bronchial asthma in a subject, said method comprising the step of administering an effective amount of a 5-HT3 receptor antagonists optionally in combination with one or more pharmaceutically acceptable excipients and more particularly the present invention relates to a method of treating bronchial asthma using ondansetron, its polymorphs, its solvates or its pharmaceutically acceptable salts.Type: ApplicationFiled: April 14, 2003Publication date: October 14, 2004Applicant: Orchid Chemicals and Pharmaceuticals Ltd.Inventors: Shiv Kumar Agarwal, Devendra Kumar Agrawal
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Patent number: 6800756Abstract: The present invention relates to preparation of Ceftiofur acid of formula (I), and its pharmaceutically acceptable salts. The process includes the steps of (i) condensing an activated derivative of wherein the activated derivative is selected from acid halides, mixed anhydrides and active amides, and wherein X represents halogen atom selected from chlorine and bromine, with silylated derivative of wherein R represents p-methoxybenzyl, p-nitrobenzyl or diphenylmethyl in the presence of a solvent at −40° C. to 0° C. to produce (ii) cyclising (V) with thiourea in the presence of water miscible solvent and sodium acetate at room temperature to produce cephalosporin (iii) deesterifying (VI) to produce (I) using anisole/trifluoroacetic acid, phenol/trifluoroacetic acid or formic acid at 0° C. to 10° C. and, if desired, (iv) converting (I), to its pharmaceutically acceptable salt.Type: GrantFiled: July 30, 2002Date of Patent: October 5, 2004Assignee: Orchid Chemicals and Pharmaceuticals, Ltd.Inventors: Pandurang Balwant Deshpande, Praven Kumar Luthra, Pratik Ramesh Sathe, Sivakumaran Sundaravadivelan, Praveen Nagesh Ganesh
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Publication number: 20040132995Abstract: The present invention relates to a process for the preparation of cephalosporin antibiotics of the formula (I) 1Type: ApplicationFiled: November 5, 2003Publication date: July 8, 2004Applicant: ORCHID CHEMICALS & PHARMACEUTICALS, LTD.Inventors: Pandurang Balwant Deshpande, Parven Kumar Luthra, Ramakrishna Kamma, Gedi Sreedhar
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Patent number: 6759395Abstract: The invention provides a novel soft gelatin capsule comprising a fill material consisting essentially of S-adenosylmethionine (SAMe) salt disposed within an enteric coated soft gelatin film.Type: GrantFiled: December 18, 2001Date of Patent: July 6, 2004Assignee: Orchid Chemicals & Pharmaceuticals, Ltd.Inventors: Canakapalli Bhaktavatsala Rao, Prasanta Kumar Chakrabarti, Hema Ravishankar
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Patent number: 6713625Abstract: The present invention provides a process for the preparation of Cefditoren of the formula (I) which comprises acylating 7-amino-cephem carboxylic acids of the general formula (IV) where R3 is hydrogen or trimethylsilyl with thioester derivatives of the formula (II) wherein R1 represents C1-C4 alkyl or phenyl in an organic solvent in the presence of an organic base at a temperature in the range of −10° C. to 30° C.Type: GrantFiled: May 23, 2002Date of Patent: March 30, 2004Assignee: Orchid Chemicals & Pharmaceuticals Ltd.Inventors: Pandurang Balwant Deshpande, Parven Kumar Luthra
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Patent number: 6649753Abstract: This invention relates to the production of new & stable salts of S-adenosyl-L-methionine SAMe). The source of SAMe used in the salt formation is from chemical process wherein stereoselective methylation of S-adenosyl-L-homocysteine is achieved. The process for the salt preparation is simple, efficient & reproducible on large scale. The new salts were found to be stable at accelerated temperature for minimum 3 months.Type: GrantFiled: June 7, 2001Date of Patent: November 18, 2003Assignee: Orchid Chemicals & Pharmaceuticals Ltd.Inventors: Pandurang Balwant Deshpande, Udayampalam Palanisamy Senthilkumar, Subramaniam Ganesan
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Patent number: 6555680Abstract: The present invention relates to a process for the preparation of sodium salt of Ceftiofur as given in Formula I, directly from its amine salt using sodium base.Type: GrantFiled: December 10, 2001Date of Patent: April 29, 2003Assignee: Orchid Chemicals & Pharmaceuticals Ltd.Inventors: Pandurang Balwant Deshpande, Pramod Narayan Deshpande, Milind Ramkrishna Kulkarni, Parven Kumar Luthra
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Patent number: 6555679Abstract: The present invention relates to a process for preparing sodium salt of cephalosporins from their corresponding hydrohalide salt, which is neutralized with trimethylsilylating agent for the first time.Type: GrantFiled: October 3, 2001Date of Patent: April 29, 2003Assignee: Orchid Chemicals & Pharmaceuticals Ltd.Inventors: Pandurang Balwant Deshpande, Bhausaheb Pandarinath Khadangale
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Patent number: 6388070Abstract: The present invention provides novel thioester derivatives of thiazolyl acetic acid of the general formula (I), wherein, R1 represents H, trityl, CH3, or CRaRbCOOR3, in which Ra and Rb, independently of one another, represents hydrogen or methyl and R3 represents H or C1-C7 alkyl; and R2 represents C1-C4 alkyl or phenyl.Type: GrantFiled: January 5, 2001Date of Patent: May 14, 2002Assignee: Orchid Chemicals & Pharmaceuticals Ltd.Inventors: Pandurang Balwant Deshpande, Parven Kumar Luthra