Patents Assigned to OREGON HEALTH & SCIENCE
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Patent number: 11578073Abstract: The present disclosure is concerned with xanthine analogs, methods of making xanthine analogs, and methods of treating West Nile virus using these analogs. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: GrantFiled: June 18, 2020Date of Patent: February 14, 2023Assignees: Southern Research Institute, Oregon Health and Science UniversityInventors: Ashish Kumar Pathak, Theresa Ha Nguyen, Corinne E. Augelli-Szafran, Alec Jay Hirsch, Jessica Lee Smith
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Patent number: 11571238Abstract: An endarterectomy device configured to remove plaque from an occluded artery is disclosed. The endarterectomy device uses an adjustable wire loop end effector to establish and advance a dissection plane in the subadventitial space of the artery. The endarterectomy device is passed down the length of an artery in the subadventitial plane, adjusting the size of the wire loop end effector as needed to navigate the artery and dissect a plaque column, until the end of the plaque is reached. The wire loop end effector is then used as a plaque cutter to transect the distal end of the plaque column. The endarterectomy device is further configured along its length with support arms that facilitate removal of the plaque column as the device is removed from the artery.Type: GrantFiled: March 27, 2020Date of Patent: February 7, 2023Assignee: Oregon Health & Science UniversityInventors: Gregory Landry, Stevan Wittenbrock, Daniel R. Baker, Christopher John Jensen
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Patent number: 11572637Abstract: Disclosed herein are methods of high-throughput mapping of viral neutralizing antibody epitopes. Also disclosed are in vitro immunoprecipitation-based adeno-associated virus Barcode-Seq-based methods of mapping viral neutralizing antibody epitopes. In some embodiments, a method of high-throughput mapping of viral NtAb conformational epitopes can be utilized, which may comprise HP scanning of mutant viral libraries, immunoprecipitation (IP), and/or next-generation sequencing (NGS) technology. In some embodiments, a method of identifying one or more dominant epitopes in a viral vector may comprise contacting a mutant capsid of a virus with serum from a subject previously exposed to the virus and immunoprecipitating serum immunoglobulins from the serum. In various embodiments, the viral vector may be an AAV vector.Type: GrantFiled: July 7, 2020Date of Patent: February 7, 2023Assignee: Oregon Health & Science UniversityInventors: Hiroyuki Nakai, Kei Adachi
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Patent number: 11566019Abstract: The present disclosure is concerned with 2-pyrimidone compounds that are capable of inhibiting a viral infection and methods of treating alphavirus viral infections such as, for example, chikungunya, Eastern equine encephalitis (EEEV), Western equine encephalitis (WEEV), and Venezuelan equine encephalitis using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: GrantFiled: April 2, 2021Date of Patent: January 31, 2023Assignees: Southern Research Institute, Oregon Health and Science UniversityInventors: Ashish Kumar Pathak, Corinne E. Augelli-Szafran, Atefeh Garzan, Daniel Streblow, Nicole Haese
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Patent number: 11564673Abstract: The present disclosure relates to a gastrointestinal delivery device of a dressing, where the delivery device is capable of fitting through a narrow channel before expanding and applying the dressing. The gastrointestinal delivery device may be used in all gastrointestinal bleeding applications and can be used with a biocompatible, foldable, thin profile, chitosan dressing. Various aspects of the device and its uses are provided herein.Type: GrantFiled: December 28, 2018Date of Patent: January 31, 2023Assignees: Tricol Biomedical, Inc., Oregon Health & Science UniversityInventors: Kenneth E. Perry, Kenneth P. Perry, Hua Xie, Brintha Enestvedt, Simon J. McCarthy
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Publication number: 20230028963Abstract: An anatomical sensing system-guided prostate procedure device that includes a housing having a proximal end and a distal end. The housing may be divided into a distal housing section, amid housing section, and a proximal housing section, wherein the distal housing section is configured for insertion into the anus and retention in the rectum of a subject. The device further includes an instrument convergence point disposed between the proximal end and the distal end, the convergence point configured to allow an instrument pass though the instrument convergence point at a variable angle; and an instrument angle orienting system at the proximal end of the housing, the angle orienting system directing an orientation of the variable angle about the convergence point. Methods of the using an anatomical sensing system-guided prostate procedure device and system including the same.Type: ApplicationFiled: October 5, 2022Publication date: January 26, 2023Applicant: Oregon Health & Science UniversityInventors: Fergus Coakley, Stevan Wittenbrock, Forrest Seitz, Christopher J. Jensen, Daniel R. Baker
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Patent number: 11554044Abstract: Disclosed are implantable ocular drainage devices that include a reversible switch mechanism to control flow through the drainage device. The devices include a drainage tube and a reversible, bi-stable switch mechanism that includes first and second stationary magnets spaced apart from one another and a magnetic or ferromagnetic mobile element moveably disposed in a channel in the housing.Type: GrantFiled: September 11, 2018Date of Patent: January 17, 2023Assignee: OREGON HEALTH & SCIENCE UNIVERSITYInventors: David Simons, Robert Kinast
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Patent number: 11554168Abstract: Provided herein are HIV-1 vaccines comprising a carrier and a population episensus antigen determined using the EpiGraph approach. Also provided are HIV-1 vaccines comprising a carrier, a population episensus antigen, and a tailored antigen. Also provided are methods of designing and producing an HIV-1 vaccine for a subject comprising designing vaccine antigens to optimally cover the diversity within a geographic area using an antigen amino acid sequence generated using the EpiGraph approach, and producing said designed vaccine antigen. Also provided are methods of inducing an effector memory T cell response comprising designing the one or more EpiGraph amino acid sequences, producing a vaccine comprising the one or more EpiGraph amino acid sequences and a vector, and administering the vaccine to a subject. Further provided are methods of treating HIV-1 in a subject comprising administering an effective amount of the described HIV-1 vaccines to the subject in need thereof.Type: GrantFiled: August 31, 2020Date of Patent: January 17, 2023Assignees: Vir Biotechnology, Inc., Triad National Security, LLC, Oregon Health & Science UniversityInventors: Eric Bruening, Klaus Frueh, Louis Picker, Bette T. M. Korber, James Theiler, Emily Marshall
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Patent number: 11543483Abstract: Methods, computer-readable storage devices, and systems are described for reducing movement of a patient undergoing a magnetic resonance imaging (MRI) scan by aligning MRI data, the method implemented on a Framewise Integrated Real-time MRI Monitoring (“FIRMM”) computing device including at least one processor in communication with at least one memory device. Aspects of the method comprise receiving a data frame from the MRI system, aligning the received data frame to a preceding data frame, calculating motion of a body part between the received data frame and the preceding data frame, calculating total frame displacement, and excluding data frames with a cutoff above a pre-identified threshold of the total frame displacement.Type: GrantFiled: October 20, 2021Date of Patent: January 3, 2023Assignees: Washington University, Oregon Health & Science UniversityInventors: Nico Dosenbach, Jonathan Koller, Andrew Van, Abraham Snyder, Amy Mirro, Damien Fair, Eric Earl, Rachel Klein, Oscar Miranda Dominguez, Anders Perrone
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Patent number: 11535883Abstract: Provided herein are methods for preparing a sequencing library that includes nucleic acids from a plurality of single cells. In one embodiment, the sequencing library includes whole genome nucleic acids from the plurality of single cells. In one embodiment, the method includes generating nucleosome-depleted nuclei by chemical treatment while maintaining integrity of the nuclei. Also provided herein are compositions, such as compositions that include chemically treated nucleosome-depleted isolated nuclei.Type: GrantFiled: July 21, 2017Date of Patent: December 27, 2022Assignees: Illumina, Inc., Oregon Health & Science UniversityInventors: Andrew C. Adey, Sarah A. Vitak, Frank J. Steemers
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Patent number: 11530235Abstract: Mutant mono ADP-ribose-polymerases (mono-PARP) proteins and small molecule compound substrates specific for the mutant mono-PARP proteins as well as methods of using these compositions to identify protein targets of the mono-PARPs and to screen for antagonists of the mono-PARPs are described.Type: GrantFiled: December 16, 2019Date of Patent: December 20, 2022Assignee: Oregon Health & Science UniversityInventors: Michael Cohen, Ian Carter-O'Connell, Rory Morgan, Haihong Jin
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Patent number: 11510887Abstract: Methods of treating a subject having or at risk of developing a neurodegenerative disease or condition associated with demyelination, insufficient myelination, or underdevelopment of myelin sheath are described. The methods include administration of a therapeutically effective amount of sobetirome, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: July 7, 2020Date of Patent: November 29, 2022Assignees: Oregon Health & Science University, The United States Government as represented by the Department of Veterans AffairsInventors: Thomas S. Scanlan, Meredith Hartley, Andrew Placzek, Marco Righi, Dennis Bourdette, Gail Marracci, Priya Chaudhary
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Publication number: 20220354969Abstract: Disclosed herein are methods for delivering a composition comprising an adeno-associated virus (AAV) to one or more pancreatic cells in a subject. Also disclosed are adeno-associated viral vectors for use in these methods.Type: ApplicationFiled: May 9, 2022Publication date: November 10, 2022Applicant: Oregon Health & Science UniversityInventors: Hiroyuki Nakai, Masahiro Horikawa, Kei Adachi
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Patent number: 11492359Abstract: The compounds provided herein are phenoxazines that can be used as far red to near-infrared nerve-sparing fluorescent compounds in medical procedures.Type: GrantFiled: July 26, 2019Date of Patent: November 8, 2022Assignee: Oregon Health & Science UniversityInventors: Summer L. Gibbs, Lei G. Wang, Connor W. Barth
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Patent number: 11471045Abstract: Disclosed are systems and methods for characterizing corneal shape abnormalities. These methods may be used to differentiate corneas having subclinical keratoconus from other conditions which cause distortion of corneal shape, including warpage of the cornea due to contact lens wear. Also disclosed is classification scheme to aid diagnosis of corneal conditions and thereby guide clinical decision making regarding patient treatment. This classification scheme is based on computed properties of corneal shape, is amenable to automation, and may be implemented in an integrated system or provided in the form of software encoded on a computer-readable medium.Type: GrantFiled: August 21, 2019Date of Patent: October 18, 2022Assignee: OREGON HEALTH & SCIENCE UNIVERSITYInventors: Maolong Tang, Yan Li, David Huang
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Patent number: 11464499Abstract: An anatomical sensing system-guided prostate procedure device that includes a housing having a proximal end and a distal end. The housing may be divided into a distal housing section, a mid housing section, and a proximal housing section, wherein the distal housing section is configured for insertion into the anus and retention in the rectum of a subject. The device further includes an instrument convergence point disposed between the proximal end and the distal end, the convergence point configured to allow an instrument pass though the instrument convergence point at a variable angle; and an instrument angle orienting system at the proximal end of the housing, the angle orienting system directing an orientation of the variable angle about the convergence point. Methods of the using an anatomical sensing system-guided prostate procedure device and system including the same.Type: GrantFiled: September 1, 2017Date of Patent: October 11, 2022Assignee: OREGON HEALTH & SCIENCE UNIVERSITYInventors: Fergus Coakley, Stevan Wittenbrock, Forrest Seitz, Christopher J. Jensen, Daniel R. Baker
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Patent number: 11464639Abstract: Methods for generating aortic heart valve leaflets are disclosed wherein the aortic sinus surfaces (the inner surfaces of the sinuses of Valsalva) are used as a template to generate geometric representations of replacement aortic heart valve leaflets. As such, sinus-matched replacement leaflets can be sized and shaped according to the patient-specific geometry of the aortic root. Patient-specific aortic valve assemblies based on aortic root and sinus geometry are also described. Methods for estimating the coaptation area of a sinus-matched valve and assessing whether the valve is functionally competent for implantation are described.Type: GrantFiled: January 31, 2019Date of Patent: October 11, 2022Assignees: Oregon Health & Science University, Iowa State University Research FoundationInventors: Gary Michael Silberbach, Ming-Chen Hsu, Xiao-Yue Han
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Patent number: 11459558Abstract: Disclosed are methods for performing transcription-dependent directed evolution (TRADE) and novel AAV capsids selected using such methods.Type: GrantFiled: June 2, 2021Date of Patent: October 4, 2022Assignee: Oregon Health & Science UniversityInventors: Hiroyuki Nakai, Samuel Huang, Kei Adachi
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Patent number: 11452442Abstract: Disclosed are systems and methods for generating wide-field optical coherence tomography angiography (OCTA) images. In embodiments, multiple OCTA scans of a sample are automatically acquired at overlapping locations. The systems and methods include functionality to adaptively control the scanning procedure such that eye blink and eye motion events are detected in real time and accounted for during 3D scan acquisition. Also disclosed are methods for detecting and correcting motion-related artifacts in OCTA datasets which allow for the longer scan times over larger fields of view required for wide-field imaging. These methods may include division of en face angiogram images into a set of motion-free parallel strips, and application of gross and fine registration methods to align overlapping strips into a motion-corrected composite image. A series of overlapping motion-corrected composite images may be combined into a larger montage to enable wide-field OCTA imaging using multiple OCTA scans.Type: GrantFiled: June 15, 2017Date of Patent: September 27, 2022Assignee: OREGON HEALTH & SCIENCE UNIVERSITYInventors: David Huang, Gangjun Liu, Yali Jia
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Patent number: D972336Type: GrantFiled: March 5, 2021Date of Patent: December 13, 2022Assignee: Oregon Health & Science UniversityInventors: Jessica L. Grant, David Sheridan, Samantha Swartz, Greg Hinzmann