Patents Assigned to Oregon Heath Science University
  • N-terminally truncated HER-2/neu protein as a cancer prognostic indicator
    Patent number: 6541214
    Abstract: There is disclosed an initial identification of an N-terminally truncated HER-2/neu product. This product is a 95 kDa polypeptide having in vitro kinase activity (as determined by western blotting). Moreover, immunoprecipitations using domain specific antibodies was able to utilize this specific polypeptide from intracellular fragments as a diagnostic and prognostic indicator of adenomacarcinomas without the severe dilution effects encountered by measuring ECD.
    Type: Grant
    Filed: November 13, 1998
    Date of Patent: April 1, 2003
    Assignee: Oregon Heath Science University
    Inventor: Gail M. Clinton