Patents Assigned to Oregon Regional Primate Research Center
  • Enhancement of fertilization capability of oocytes
    Patent number: 5693534
    Abstract: A method is provided for increasing the fertilization potential of oocytes comprising culturing oocytes in vitro with an effective amount of inhibin, activin, or a combination of inhibin and activin. Preferably the oocytes being cultured are immature. After the culturing step, the oocytes can be fertilized. The oocytes are suitably cryopreserved and thawed before the culturing step.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: December 2, 1997
    Assignees: Genentech, Inc., Oregon Regional Primate Research Center
    Inventors: Baha M. Alak, Richard L. Stouffer, Don P. Wolf, Teresa K. Woodruff
  • Nucleic acids encoding receptors for bombesin-like peptides
    Patent number: 5656749
    Abstract: Pure nucleic acids encoding novel receptors for bombesin-like peptides, the novel receptors themselves, and their antibodies. Also disclosed is a method of screening for a compound capable of interacting with any of these novel receptors.
    Type: Grant
    Filed: July 22, 1994
    Date of Patent: August 12, 1997
    Assignee: Oregon Regional Primate Research Center
    Inventors: Eliot R. Spindel, Srinivasa Nagalla, Brenda Barry
  • Method of controlling fertilization using bombesin or its agonist
    Patent number: 5439884
    Abstract: A method of promoting or blocking fertilization, which method includes the step of contacting sperm either at the time of sperm capacitation or at the time of egg fertilization with an effective amount of bombesin or its analog capable of stimulating or inhibiting the acrosome reaction.
    Type: Grant
    Filed: July 27, 1992
    Date of Patent: August 8, 1995
    Assignee: Oregon Regional Primate Research Center
    Inventors: Eliot R. Spindel, Srinivasa R. Nagalla, Srinivasan Vijayaraghavan, Anthony Archibong
  • DNA sequence which encodes a peptide capable of promoting acrosome reaction
    Patent number: 5436137
    Abstract: A pure DNA encoding a peptide which is capable of promoting acrosome reaction and the encoded peptide. Also disclosed are a vector and a cell containing such a DNA, a pharmaceutical composition which includes such a peptide, a method of promoting fertilization using such a peptide, and a method of preparing such a peptide by recombinant technology.
    Type: Grant
    Filed: March 23, 1993
    Date of Patent: July 25, 1995
    Assignee: Oregon Regional Primate Research Center
    Inventors: Eliot R. Spindel, Srinivasan Vijayaraghavan, Srinivasa R. Nagalla, Kang Li
  • Bombesin-related peptides
    Patent number: 5410018
    Abstract: A pure DNA encoding a peptide which encodes a novel bombesin-related peptide, i.e., H-pGlu-Gln-Ser-Leu-Gly-Asn-Gin-Trp-Ala-Arg-Gly-His-Phe-Met-NH.sub.2 or Gly-Asn-Gln-Trp-Ala-Arg-Gly-His-Phe-Met-NH.sub.2. Also disclosed are a vector and a cell containing such a DNA, a pharmaceutical composition which includes such a peptide, and a method of preparing such a peptide by recombinant technology.
    Type: Grant
    Filed: February 25, 1994
    Date of Patent: April 25, 1995
    Assignee: Oregon Regional Primate Research Center
    Inventors: Eliot R. Spindel, Srinivasa Nagalla, Brenda Barry