Abstract: The present invention relates to aspects of drain cleaning compositions, methods, and systems involving multiple levels of attack to facilitate decomposition of clogs in pipe systems. Aspects of the invention relate to a multi-action drain cleaning composition including chemical and biological components capable of producing an exothermic reaction, an oxidation reaction, and an enzymatic reaction. Generally, the chemical components act immediately to clear a clog in a pipe system and the biological components act over a longer period of time to provide longer-term maintenance of the pipe system. Additional aspects of the invention relate to a composition for use as a component of a multi-action drain cleaner that includes bacteria selectively cultured to subsist in a peroxygen-rich environment, a high-heat environment, and/or a high-pH environment. A bio-film for reducing or preventing a buildup of organic material in a pipe system including a matrix and a selectively cultured bacteria is also provided.