Patents Assigned to OrganoBalance GmbH
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Publication number: 20170198328Abstract: The present invention relates to a method for preparing 7-dehydrocholesterol and/or the biosynthetic intermediates and/or secondary products thereof by culturing organisms, in particular yeasts. Furthermore, the invention relates to the preparation of the nucleic acid constructs required for preparing the genetically modified organisms and to said genetically modified organisms, in particular yeasts, themselves.Type: ApplicationFiled: January 23, 2017Publication date: July 13, 2017Applicant: Organobalance GmbHInventors: Christine Lang, Markus Veen
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Patent number: 9598710Abstract: The invention provides an isolated genetically modified non-mammalian organism, wherein the activity of acyl-CoA:sterol acyltransferase/sterol O-acyltransferase (EC 2.3.1.26) and/or diacylglycerol acyltransferase/diacylglycerol O-acyltranferase (EC 2.3.1.20) and/or lecithin cholesterol acyl transferase/phospholipid:diacylglycerol acyltransferase (EC 2.3.1.158) and/or acyl CoA-wax alcohol acyltransferase (EC 2.3.1.75) is reduced or abolished in comparison with a corresponding wildtype organism, methods of use of such an organism, shuttle vehicles for making such an organism and methods for producing such an organism.Type: GrantFiled: September 19, 2014Date of Patent: March 21, 2017Assignee: ORGANOBALANCE GMBHInventors: Christine Lang, Andreas Raab
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Publication number: 20150374764Abstract: Subject of the invention is a food composition comprising Lactobacillus, or a Lactobacillus preparation, which comprises Lactobacillus cell walls, cell wall fragments and/or cell wall constituents, which is capable of aggregating Helicobacter pylori under physiological conditions, and a carrier, wherein the carrier comprises skim milk. Subject of the invention are also methods for producing such food compositions and uses thereof.Type: ApplicationFiled: February 5, 2014Publication date: December 31, 2015Applicant: ORGANOBALANCE GMBHInventors: Karen T. ROBINS, Judith MAZOTTI, Kurt GASSER
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Patent number: 9220672Abstract: The present invention relates to a peptide of the following formula (I) X1(X2)-X3-X4 or a salt or solvate thereof, wherein is an amino acid comprising two or more NH-functionalities, and X2, X3, and X4 are, independently from one another, an amino acid residue, and wherein the salt or solvate is preferably a physiologically acceptable salt or solvate.Type: GrantFiled: February 3, 2012Date of Patent: December 29, 2015Assignee: ORGANOBALANCE GMBHInventor: Christine Lang
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Publication number: 20150353980Abstract: The present invention relates to a method for preparing 7-dehydrocholesterol and/or the biosynthetic intermediates and/or secondary products thereof by culturing organisms, in particular yeasts. Furthermore, the invention relates to the preparation of the nucleic acid constructs required for preparing the genetically modified organisms and to said genetically modified organisms, in particular yeasts, themselves.Type: ApplicationFiled: December 26, 2014Publication date: December 10, 2015Applicant: ORGANOBALANCE GMBHInventors: Christine Lang, Markus Veen
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Patent number: 9051587Abstract: The present invention relates to a yeast cell, wherein said cell comprises a functional gene coding for soluble hydroxymethylglutaryl-coenzyme-A (HMG-CoA) reductase; one or more gene(s) coding for steryl acyltransferase(s) in said cell are defective or deleted; and said cell is prototrophic for at least histidine, leucine or uracil. Moreover, the present invention relates to the use of said cell for the production of one or more terpene(s). Further, the present invention relates to methods of generating said cell and the production of one or more terperne(s) and a pharmaceutical or cosmetically composition, a lubricant or transformer oil comprising said terpene(s).Type: GrantFiled: February 15, 2012Date of Patent: June 9, 2015Assignee: OrganoBalance GmbHInventors: Andreas Raab, Christine Lang
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Publication number: 20150024009Abstract: The invention provides an isolated genetically modified non-mammalian organism, wherein the activity of acyl-CoA:sterol acyltransferase/sterol O-acyltransferase (EC 2.3.1.26) and/or diacylglycerol acyltransferase/diacylglycerol O-acyltranferase (EC 2.3.1.20) and/or lecithin cholesterol acyl transferase/phospholipid: diacylglycerol acyltransferase (EC 2.3.1.158) and/or acyl CoA-wax alcohol acyltransferase (EC 2.3.1.75) is reduced or abolished in comparison with a corresponding wildtype organism, methods of use of such an organism, shuttle vehicles for making such an organism and methods for producing such an organism.Type: ApplicationFiled: September 19, 2014Publication date: January 22, 2015Applicant: ORGANOBALANCE GMBHInventors: Christine Lang, Andreas Raab
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Patent number: 8841114Abstract: The invention provides an isolated genetically modified non-mammalian organism, wherein the activity of acyl-CoA: sterol acyltransferase/sterol O-acyltransferase (EC 2.3.1.26) and/or diacylglycerol acyltransferase/diacylglycerol O-acyltranferase (EC 2.3.1.20) and/or lecithin cholesterol acyl transferase/phospholipid: diacylglycerol acyltransferase (EC 2.3.1.158) and/or acyl CoA-wax alcohol acyltransferase (EC 2.3.1.75) is reduced or abolished in comparison with a corresponding wildtype organism, methods of use of such an organism, shuttle vehicles for making such an organism and methods for producing such an organism.Type: GrantFiled: August 4, 2010Date of Patent: September 23, 2014Assignee: OrganoBalance GmbHInventors: Christine Lang, Andreas Raab
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Publication number: 20140147427Abstract: The invention relates to spray-dried Lactobacillus strains and/or Lactobacillus cells (lactic acid bacteria) and to the uses thereof, in particular for pharmaceutical and/or dietary compositions for the treatment and prophylaxis of Helicobacter pylori infections in humans and animals.Type: ApplicationFiled: June 8, 2012Publication date: May 29, 2014Applicant: OrganoBalance GmbHInventors: Stefanie Arya, Detlef Goelling, Caterina Holz, Christine Lang
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Publication number: 20140072542Abstract: Described are microorganisms which are, in a first aspect, able to to stimulate the growth of microorganisms of the resident skin microbial flora and which do not stimulate the growth of microorganisms of the transient pathogenic micro flora. In a second aspect microorganisms are described which are able to inhibit the growth of microorganisms of the transient pathogenic skin micro flora and which do not inhibit the growth of microorganisms of the resident skin micro flora. Also described are compositions comprising such microorganisms as well as the use of such microorganisms in cosmetic, prophylactic or therapeutic applications.Type: ApplicationFiled: November 18, 2013Publication date: March 13, 2014Applicant: OrganoBalance GmbHInventors: Christine Lang, Andreas Heilmann, Markus Veen, Eckhard Budde, Mewes Boettner, Andreas Reindl, Rolf Knöll
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Publication number: 20140057850Abstract: The present invention relates to a peptide of the following formula (I) X1(X2)-X3-X4 or a salt or solvate thereof, wherein is an amino acid comprising two or more NH-functionalities, and X2, X3, and X4 are, independently from one another, an amino acid residue, and wherein the salt or solvate is preferably a physiologically acceptable salt or solvate.Type: ApplicationFiled: February 3, 2012Publication date: February 27, 2014Applicant: ORGANOBALANCE GMBHInventor: Christine Lang
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Publication number: 20130210072Abstract: The present invention relates to a method for preparing 7-dehydrocholesterol and/or the biosynthetic intermediates and/or secondary products thereof by culturing organisms, in particular yeasts. Furthermore, the invention relates to the preparation of the nucleic acid constructs required for preparing the genetically modified organisms and to said genetically modified organisms, in particular yeasts, themselves.Type: ApplicationFiled: July 13, 2012Publication date: August 15, 2013Applicant: ORGANOBALANCE GMBHInventors: Christine Lang, Markus Veen
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Publication number: 20120328586Abstract: Described are microorganisms which are, in a first aspect, able to stimulate the growth of microorganisms of the resident skin microbial flora and which do not stimulate the growth of microorganisms of the transient pathogenic micro flora. In a second aspect microorganisms are described which are able to inhibit the growth of microorganisms of the transient pathogenic skin micro flora and which do not inhibit the growth of microorganisms of the resident skin micro flora. Also described are compositions comprising such microorganisms as well as the use of such microorganisms in cosmetic, prophylactic or therapeutic applications.Type: ApplicationFiled: September 5, 2012Publication date: December 27, 2012Applicant: Organobalance GmbHInventors: Christine Lang, Andreas Heilmann, Markus Veen, Eckhard Budde, Mewes Boettner, Andreas Reindl, Rolf Knöll
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Publication number: 20120156695Abstract: The invention relates to an isolated, genetically modified, living non-mammal organism, having increased HMG-CoA-reductase activity compared to the wild type, and having reduced C24-methyltransferase and/or delta22-desaturase activity compared to the wild type. The invention is characterized in that the organism has increased dehydrocholesterol-delta70-reductase activity compared to the wild type. The invention further relates to different uses of such an organism, to a test kit comprising such an organism, and to a membrane extract of such an organism.Type: ApplicationFiled: April 1, 2010Publication date: June 21, 2012Applicant: ORGANOBALANCE GMBHInventors: Michael Schilling, Christine Lang, Andreas Raab
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Publication number: 20120156249Abstract: The invention provides an isolated genetically modified non-mammalian organism, wherein the activity of acyl-CoA: sterol acyltransferase/sterol O-acyltransferase (EC 2.3.1.26) and/or diacylglycerol acyltransferase/diacylglycerol O-acyltranferase (EC 2.3.1.20) and/or lecithin cholesterol acyl transferase/phospholipid: diacylglycerol acyltransferase (EC 2.3.1.158) and/or acyl CoA-wax alcohol acyltransferase (EC 2.3.1.75) is reduced or abolished in comparison with a corresponding wildtype organism, methods of use of such an organism, shuttle vehicles for making such an organism and methods for producing such an organism.Type: ApplicationFiled: August 4, 2010Publication date: June 21, 2012Applicant: ORGANOBALANCE GMBHInventors: Christine Lang, Andreas Raab
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Publication number: 20120020942Abstract: The invention concerns new isolated Lactobacillus cells, which are capable of aggregating Helicobacter pylori under culture conditions of the human digestive tract, in particular of the stomach, and to the uses of such cells.Type: ApplicationFiled: October 12, 2006Publication date: January 26, 2012Applicant: Organobalance, GMBHInventors: Mewes Bottner, Eckhard Budde, Christine Lang, Martin Ryser, Markus Veen
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Publication number: 20110151509Abstract: The present invention relates to a method for preparing 7-dehydrocholesterol and/or the biosynthetic intermediates and/or secondary products thereof by culturing organisms, in particular yeasts. Furthermore, the invention relates to the preparation of the nucleic acid constructs required for preparing the genetically modified organisms and to said genetically modified organisms, in particular yeasts, themselves.Type: ApplicationFiled: October 27, 2009Publication date: June 23, 2011Applicant: ORGANOBALANCE GMBHInventors: Christine Lang, Markus Veen
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Publication number: 20110117068Abstract: Described are microorganism which are able to reduce the generation of feces odor by decreasing the amount of at least one of the compounds methyl mercaptan, a sulphide compound, cadavarine, putrescine, indole or skatole, and wherein said decrease in the amount of said compounds is independent of the growth of the microorganism. Also described are compositions, comprising such microorganisms, e.g. food, feed or pharmaceutical compositions and the use of such microorganisms for suppressing feces odor or the preparation of foodstuff or feedstuff, as well as corresponding methods for the production of food or feed composition and additives for food, feed or drinks.Type: ApplicationFiled: August 20, 2007Publication date: May 19, 2011Applicant: OrganoBalance GmbHInventors: Christine Lang, Stefanie Arya, Natalia Bolotina, Markus Veen, Mewes Böttner, Eckhard Budde, Andreas Künkel, Angelika-Maria Pfeiffer
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Patent number: 7846711Abstract: The invention concerns new isolated Lactobacillus cells, which are capable to aggregate Helicobacter pylori under culture conditions of the human digestive tract, in particular of the stomach, and to the uses of such cells.Type: GrantFiled: December 22, 2006Date of Patent: December 7, 2010Assignee: Organobalance GmbHInventors: Mewes Boettner, Eckhard Budde, Christine Lang, Martin Ryser, Markus Veen
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Publication number: 20100086520Abstract: Described are compositions and kits comprising: (i) microorganisms which are able to stimulate the growth of microorganisms of the resident skin microbial flora and which do not stimulate the growth of microorganisms of the transient pathogenic micro flora and (ii) microorganisms which are able to inhibit the growth of one or more microorganisms of the transient pathogenic skin micro flora and which do not inhibit the growth of microorganisms of the healthy normal resident skin micro flora, in order to protect the skin against pathogenic microorganisms and to treat skin diseases. The present invention also relates to uses of the above mentioned microorganisms and to methods for the production of compositions and kits comprising such microorganisms.Type: ApplicationFiled: November 29, 2007Publication date: April 8, 2010Applicant: OrganoBalance GmbHInventors: Andreas Reindl, Christine Lang, Markus Veen, Andreas Heilmann, Mewes Boettner