Patents Assigned to Organovo, Inc.
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Patent number: 11867689Abstract: Disclosed are renal tissues and arrays thereof that include a layer of renal interstitial tissue, the renal interstitial tissue comprising renal fibroblasts and endothelial cells; and a layer of renal epithelial tissue, the renal epithelial tissue comprising renal tubular epithelial cells, the renal epithelial tissue in contact with the layer of renal interstitial tissue to form a three-dimensional, engineered, biological renal tissue. Also disclosed are methods of fabricating and using the same.Type: GrantFiled: March 25, 2021Date of Patent: January 9, 2024Assignee: ORGANOVO, INC.Inventors: Deborah Lynn Greene Nguyen, Shelby Marie King, Sharon C. Presnell
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Patent number: 11850330Abstract: Disclosed are compositions comprising cellular constructs comprising mesenchymal cells and epithelial cells. Also disclosed are methods of making the cellular constructs, methods of hair restoration, and kits. The invention also discloses parallel bio-printing systems and methods for making cellular constructs, such as cellular constructs comprising mesenchymal cells and epithelial cells.Type: GrantFiled: November 10, 2017Date of Patent: December 26, 2023Assignee: Organovo, Inc.Inventors: Emily Bozek, Jonah Cool, Harry S. Rapoport, Christian Holmes, Stephen L. Pentoney, Chad Viergever, Howard Hwang, Christopher Shaw
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Patent number: 11773094Abstract: Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.Type: GrantFiled: June 16, 2021Date of Patent: October 3, 2023Assignee: ORGANOVO, INC.Inventors: Nicholas D. Smith, Steven P. Govek, Karensa L. Douglas, Andiliy G. Lai
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Patent number: 11655456Abstract: Disclosed are methods of assessing the ability of a candidate therapeutic agent to reverse, reduce or prevent intestinal injury by a potential toxic agent using a three-dimensional, engineered, bioprinted, biological intestinal tissue model. Also disclosed are methods of assessing the effect of an agent on intestinal function, the method comprising contacting the agent with a three-dimensional, engineered, bioprinted, biological intestinal tissue model.Type: GrantFiled: November 10, 2017Date of Patent: May 23, 2023Assignee: Organovo, Inc.Inventors: Kelsey Nicole Retting, Deborah Lynn Greene Nguyen, Lauran Madden
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Patent number: 11577450Abstract: Described herein are bioprinters comprising: one or more printer heads, wherein a printer head comprises a means for receiving and holding at least one cartridge, and wherein said cartridge comprises contents selected from one or more of: bio-ink and support material; a means for calibrating the position of at least one cartridge; and a means for dispensing the contents of at least one cartridge. Further described herein are methods for fabricating a tissue construct, comprising: a computer module receiving input of a visual representation of a desired tissue construct; a computer module generating a series of commands, wherein the commands are based on the visual representation and are readable by a bioprinter; a computer module providing the series of commands to a bioprinter; and the bioprinter depositing bio-ink and support material according to the commands to form a construct with a defined geometry.Type: GrantFiled: September 22, 2021Date of Patent: February 14, 2023Assignee: Organovo, Inc.Inventors: Keith Murphy, Scott Dorfman, Nathan Smith, Larry Bauwens, Ian Sohn, Tim McDonald, Chris Leigh-Lancaster, Richard Jin Law
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Patent number: 11577451Abstract: Described herein are bioprinters comprising: one or more printer heads, wherein a printer head comprises a means for receiving and holding at least one cartridge, and wherein said cartridge comprises contents selected from one or more of: bio-ink and support material; a means for calibrating the position of at least one cartridge; and a means for dispensing the contents of at least one cartridge. Further described herein are methods for fabricating a tissue construct, comprising: a computer module receiving input of a visual representation of a desired tissue construct; a computer module generating a series of commands, wherein the commands are based on the visual representation and are readable by a bioprinter; a computer module providing the series of commands to a bioprinter; and the bioprinter depositing bio-ink and support material according to the commands to form a construct with a defined geometry.Type: GrantFiled: September 23, 2021Date of Patent: February 14, 2023Assignee: Organovo, Inc.Inventors: Keith Murphy, Scott Dorfman, Nathan Smith, Larry Bauwens, Ian Sohn, Tim McDonald, Chris Leigh-Lancaster, Richard Jin Law
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Patent number: 11529436Abstract: Disclosed are bioprinted, three-dimensional, biological skin tissues comprising: a dermal layer comprising dermal fibroblasts; and an epidermal layer comprising keratinocytes, the epidermal layer in contact with the dermal layer to form the three-dimensional, engineered, biological skin tissue. Also disclosed are arrays of engineered skin tissues and methods of making engineered skin tissues.Type: GrantFiled: November 5, 2015Date of Patent: December 20, 2022Assignees: Organovo, Inc., L'OrealInventors: Kelsey Nicole Retting, Colin M. O'Neill, Deborah Lynn Greene Nguyen, Sharon C. Presnell, Jessica Langer, Guive Balooch, Elizabeth Wu, Julien Demaude
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Patent number: 11413805Abstract: Described herein are bioprinters comprising: one or more printer heads, wherein a printer head comprises a means for receiving and holding at least one cartridge, and wherein said cartridge comprises contents selected from one or more of: bio-ink and support material; a means for calibrating the position of at least one cartridge; and a means for dispensing the contents of at least one cartridge. Further described herein are methods for fabricating a tissue construct, comprising: a computer module receiving input of a visual representation of a desired tissue construct; a computer module generating a series of commands, wherein the commands are based on the visual representation and are readable by a bioprinter; a computer module providing the series of commands to a bioprinter; and the bioprinter depositing bio-ink and support material according to the commands to form a construct with a defined geometry.Type: GrantFiled: September 24, 2021Date of Patent: August 16, 2022Assignee: Organovo, Inc.Inventors: Keith Murphy, Scott Dorfman, Nathan Smith, Larry Bauwens, Ian Sohn, Tim McDonald, Chris Leigh-Lancaster, Richard Jin Law
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Publication number: 20220229045Abstract: Disclosed are methods of assessing the ability of a candidate therapeutic agent to reverse, reduce or prevent renal injury by a potential toxic agent using a three-dimensional, engineered, bioprinted, biological renal tubule model. Also disclosed are methods of assessing the effect of an agent on renal function, the method comprising contacting the agent with a three-dimensional, engineered, bioprinted, biological renal tubule model. Also disclosed are models of renal disorder. In one embodiment, disclosed are models of renal fibrosis, comprising a three-dimensional, engineered, bioprinted, biological renal tubule model. Also disclosed are methods of making the model of renal disorder. In one embodiment disclosed are methods of making the model of renal fibrosis comprising contacting a three-dimensional, engineered, bioprinted, biological renal tubule model with an agent that is capable of inducing interstitial fibrotic tissue formation.Type: ApplicationFiled: January 26, 2022Publication date: July 21, 2022Applicant: Organovo, Inc.Inventors: Shelby Marie KING, Deborah Lynn Greene NGUYEN, Sharon C. PRESNELL
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Patent number: 11268950Abstract: Disclosed are methods of assessing the ability of a candidate therapeutic agent to reverse, reduce or prevent renal injury by a potential toxic agent using a three-dimensional, engineered, bioprinted, biological renal tubule model. Also disclosed are methods of assessing the effect of an agent on renal function, the method comprising contacting the agent with a three-dimensional, engineered, bioprinted, biological renal tubule model. Also disclosed are models of renal disorder. In one embodiment, disclosed are models of renal fibrosis, comprising a three-dimensional, engineered, bioprinted, biological renal tubule model. Also disclosed are methods of making the model of renal disorder. In one embodiment disclosed are methods of making the model of renal fibrosis comprising contacting a three-dimensional, engineered, bioprinted, biological renal tubule model with an agent that is capable of inducing interstitial fibrotic tissue formation.Type: GrantFiled: September 28, 2017Date of Patent: March 8, 2022Assignee: Organovo, Inc.Inventors: Shelby Marie King, Deborah Lynn Greene Nguyen, Sharon C. Presnell
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Publication number: 20220009157Abstract: Described herein are bioprinters comprising: one or more printer heads, wherein a printer head comprises a means for receiving and holding at least one cartridge, and wherein said cartridge comprises contents selected from one or more of: bio-ink and support material; a means for calibrating the position of at least one cartridge; and a means for dispensing the contents of at least one cartridge. Further described herein are methods for fabricating a tissue construct, comprising: a computer module receiving input of a visual representation of a desired tissue construct; a computer module generating a series of commands, wherein the commands are based on the visual representation and are readable by a bioprinter; a computer module providing the series of commands to a bioprinter; and the bioprinter depositing bio-ink and support material according to the commands to form a construct with a defined geometry.Type: ApplicationFiled: September 23, 2021Publication date: January 13, 2022Applicant: ORGANOVO, INC.Inventors: Keith MURPHY, Scott DORFMAN, Nathan SMITH, Larry BAUWENS, Ian SOHN, Tim MCDONALD, Chris LEIGH-LANCASTER, Richard Jin LAW
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Publication number: 20220009158Abstract: Described herein are bioprinters comprising: one or more printer heads, wherein a printer head comprises a means for receiving and holding at least one cartridge, and wherein said cartridge comprises contents selected from one or more of: bio-ink and support material; a means for calibrating the position of at least one cartridge; and a means for dispensing the contents of at least one cartridge. Further described herein are methods for fabricating a tissue construct, comprising: a computer module receiving input of a visual representation of a desired tissue construct; a computer module generating a series of commands, wherein the commands are based on the visual representation and are readable by a bioprinter; a computer module providing the series of commands to a bioprinter; and the bioprinter depositing bio-ink and support material according to the commands to form a construct with a defined geometry.Type: ApplicationFiled: September 24, 2021Publication date: January 13, 2022Applicant: ORGANOVO, INC.Inventors: Keith MURPHY, Scott DORFMAN, Nathan SMITH, Larry BAUWENS, Ian SOHN, Tim MCDONALD, Chris LEIGH-LANCASTER, Richard Jin LAW
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Publication number: 20220009156Abstract: Described herein are bioprinters comprising: one or more printer heads, wherein a printer head comprises a means for receiving and holding at least one cartridge, and wherein said cartridge comprises contents selected from one or more of: bio-ink and support material; a means for calibrating the position of at least one cartridge; and a means for dispensing the contents of at least one cartridge. Further described herein are methods for fabricating a tissue construct, comprising: a computer module receiving input of a visual representation of a desired tissue construct; a computer module generating a series of commands, wherein the commands are based on the visual representation and are readable by a bioprinter; a computer module providing the series of commands to a bioprinter; and the bioprinter depositing bio-ink and support material according to the commands to form a construct with a defined geometry.Type: ApplicationFiled: September 22, 2021Publication date: January 13, 2022Applicant: ORGANOVO, INC.Inventors: Keith Murphy, Scott Dorfman, Nathan Smith, Larry Bauwens, Ian Sohn, Tim McDonald, Chris Leigh-Lancaster, Richard Jin Law
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Publication number: 20210291432Abstract: Described herein are bioprinters comprising: one or more printer heads, wherein a printer head comprises a means for receiving and holding at least one cartridge, and wherein said cartridge comprises contents selected from one or more of: bio-ink and support material; a means for calibrating the position of at least one cartridge; and a means for dispensing the contents of at least one cartridge. Further described herein are methods for fabricating a tissue construct, comprising: a computer module receiving input of a visual representation of a desired tissue construct; a computer module generating a series of commands, wherein the commands are based on the visual representation and are readable by a bioprinter; a computer module providing the series of commands to a bioprinter; and the bioprinter depositing bio-ink and support material according to the commands to form a construct with a defined geometry.Type: ApplicationFiled: March 15, 2021Publication date: September 23, 2021Applicant: ORGANOVO, INC.Inventors: Keith Murphy, Scott Dorfman, Nathan Smith, Larry Bauwens, Ian Sohn, Tim McDonald, Chris Leigh-Lancaster, Richard Jin Law
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Patent number: 11124774Abstract: Engineered, living, three-dimensional liver tissue constructs including: one or more layers, wherein each layer contains one or more liver cell types, the one or more layers cohered to form a living, three-dimensional liver tissue construct free of pre-formed scaffold. Also disclosed are arrays and methods of making the same.Type: GrantFiled: July 18, 2019Date of Patent: September 21, 2021Assignee: Organovo, Inc.Inventors: Benjamin R. Shepherd, Justin B. Robbins, Vivian A. Gorgen, Sharon C. Presnell
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Patent number: 10967560Abstract: Described herein are bioprinters comprising: one or more printer heads, wherein a printer head comprises a means for receiving and holding at least one cartridge, and wherein said cartridge comprises contents selected from one or more of: bio-ink and support material; a means for calibrating the position of at least one cartridge; and a means for dispensing the contents of at least one cartridge. Further described herein are methods for fabricating a tissue construct, comprising: a computer module receiving input of a visual representation of a desired tissue construct; a computer module generating a series of commands, wherein the commands are based on the visual representation and are readable by a bioprinter; a computer module providing the series of commands to a bioprinter; and the bioprinter depositing bio-ink and support material according to the commands to form a construct with a defined geometry.Type: GrantFiled: November 17, 2017Date of Patent: April 6, 2021Assignee: Organovo, Inc.Inventors: Keith Murphy, Scott Dorfman, Nathan Smith, Larry Bauwens, Ian Sohn, Tim McDonald, Chris Leigh-Lancaster, Richard Jin Law
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Patent number: 10962526Abstract: Disclosed are renal tissues and arrays thereof that include a layer of renal interstitial tissue, the renal interstitial tissue comprising renal fibroblasts and endothelial cells; and a layer of renal epithelial tissue, the renal epithelial tissue comprising renal tubular epithelial cells, the renal epithelial tissue in contact with the layer of renal interstitial tissue to form a three-dimensional, engineered, biological renal tissue. Also disclosed are methods of fabricating and using the same.Type: GrantFiled: October 8, 2018Date of Patent: March 30, 2021Assignee: Organovo, Inc.Inventors: Deborah Lynn Greene Nguyen, Shelby Marie King, Sharon C. Presnell
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Publication number: 20210008788Abstract: Described herein are improvements to bioprinting technology that facilitate automation of tissue and organ fabrication processes.Type: ApplicationFiled: April 30, 2020Publication date: January 14, 2021Applicant: Organovo, Inc.Inventors: Keith MURPHY, Stephen PENTONEY, JR., Frank LIN, Vivian GORGEN, Clay PLATT, Harry Scott RAPOPORT, Samir DAMLE, Vaidehi JOSHI, Sharon C. PRESNELL
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Publication number: 20200018747Abstract: Disclosed are methods of assessing the ability of a candidate therapeutic agent to reverse, reduce or prevent renal injury by a potential toxic agent using a three-dimensional, engineered, bioprinted, biological renal tubule model. Also disclosed are methods of assessing the effect of an agent on renal function, the method comprising contacting the agent with a three-dimensional, engineered, bioprinted, biological renal tubule model. Also disclosed are models of renal disorder. In one embodiment, disclosed are models of renal fibrosis, comprising a three-dimensional, engineered, bioprinted, biological renal tubule model. Also disclosed are methods of making the model of renal disorder. In one embodiment disclosed are methods of making the model of renal fibrosis comprising contacting a three-dimensional, engineered, bioprinted, biological renal tubule model with an agent that is capable of inducing interstitial fibrotic tissue formation.Type: ApplicationFiled: September 28, 2017Publication date: January 16, 2020Applicant: Organovo, Inc.Inventors: Shelby Marie KING, Deborah Lynn Greene NGUYEN, Sharon C. PRESNELL
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Patent number: 10400219Abstract: Engineered, living, three-dimensional liver tissue constructs including: one or more layers, wherein each layer contains one or more liver cell types, the one or more layers cohered to form a living, three-dimensional liver tissue construct free of pre-formed scaffold. Also disclosed are arrays and methods of making the same.Type: GrantFiled: May 26, 2016Date of Patent: September 3, 2019Assignee: Organovo, Inc.Inventors: Benjamin R. Shepherd, Justin B. Robbins, Vivian A. Gorgen, Sharon C. Presnell